EUROCORES - EuroEPINOMICS

Titel des Programms
Functional genomic variation in the epilepsies (EuroEPINOMICS)

Teilnehmende Länder
Austria, Belgium, Croatia, Estonia, Finland, Germany, Luxembourg, Norway, Poland, Portugal, Romania, Spain, Switzerland and Turkey

Ziel
Epilepsy is a common, serious neurological disorders affecting about 6 million people in Europe. The objectives of EuroEPINOMICS are to identify novel epilepsy genes and genetic variants predisposing to epilepsy and drug response, and to unravel their molecular pathways. EuroEPINOMICS aims to establish a comprehensive research programme that brings together scientific expertise and resources of leading European research groups to provide high-resolution maps of genetic risk factors for common epilepsy syndromes, to dissect genetic determinants of the response to antiepileptic drugs, and to elucidate the mechanisms of epileptogenesis. The long-term scientific goals are the identification of novel therapeutic targets and an individualized pharmacotherapy.
Inhalt

The programme will explore the genetics and pathophysiology of well defined epilepsy phenotypes and pharmacoresponses, including:

(i) Idiopathic Generalized Epilepsies (IGEs)
(ii) Mesial Temporal Lobe Epilepsy (MTLE)
(iii) Febrile Seizures (FS)
(iv) Rare monogenic Epilepsy Syndromes (RES) and epileptic encephalopathies, for which the responsible genes have not been identified
(v) Pharmacoresponse to antiepileptic drugs and adverse reactions including teratogenicity:
(vi) Animal models of primary generalized epilepsies.

Detailinformation
www.esf.org/euroepinomics
Dr. Maria Manuela Nogueira
EUROCORES Programme Coordinator for EuroEPINOMICS
Tel: 0033-388767145
Email: mnogueira@esf.org oder Euroepinomics@esf.org

Ansprechperson im FWF
Dr. Milojka Gindl

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