PhD or Postdoctoral Position
- Electrophysiology / Ion Channels / Neuroscience
- Medical University Innsbruck, Dept. Physiology
Project: Regulation of voltage-sensitivity of CaV1 calcium channels.
In nerve and muscle cells voltage-activated calcium channels control activity-dependent cell functions like muscle contraction and neurotransmitter secretion. Recently we described a novel molecular mechanism important for the regulation of voltage-sensitivity of CaV1.1 by alternative splicing. Here we will combine state-of-the-art molecular biology with structure modeling and electrophysiological analysis to unravel the molecular mechanism by which different calcium channels determine their distinct voltage sensitivities and adjust them to their specific demands.
Methods: Patch-clamp / voltage-clamp recording, fluorescent calcium recording, site-directed mutagenesis, reconstitution of null-mutant myotubes with recombinant CaV1 channels, immunofluorescence staining.
References: Tuluc et al., 2015, Structure, 24:261-271; Tuluc et al., 2016 J. Gen. Physiology, 147:437-449; Flucher and Tuluc 2017, J. Physiol., 595:1451-1463; Campiglio and Flucher, 2017, Sci. Rep., 7:41003.
Requirements: Master degree (or equivalent) and experience in electrophysiology techniques (path-clamp)
Salary: According to FWF rates for PhD students or postdocs plus travel funds for international scientific meetings (http://www.fwf.ac.at/de/forschungsfoerderung/personalkostensaetze/).
The successful candidate will be part of a highly active research group which is well integrated in the lively calcium channel research environment in Innsbruck, and participates in the doctoral program in Molecular Cell Biology and Oncology (www.mcbo.at), as well as in the special research focus on Cell signaling in chronic CNS disorders (http://www.uibk.ac.at/pharmazie/pharmakologie/sfb-f44/) both funded by the Austrian Science Fund.
Starting date: October 1st, 2017
- Name: Ao. Univ.-Prof. Dr. Bernhard Flucher
- Telefon: +43-512-9003-70836