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Job-Art: Wissenschaftliche Jobausschreibungen

Making (cytosine-5) RNA methylation programmable using RNA-targeting Cas9 (RCas9)

Fachgebiet
Basics in molecular biology and tissue culture work
Arbeitsstätte
Center for Anatomy and Cell Biology, Division of Cell and Developmental Biology
Website
Bewerbungsfrist
30.11.2017

Ausschreibungstext

The project is based on a recently developed approach using nuclease-inactive S. pyogenes CRISPR/Cas9 that can bind RNA in a nucleic-acid-programmed manner allowing to manipulate endogenous RNAs in living cells.

The focus of this project will be developing a system that allows introducing m5C at specific positions (5’-UTR, 3’-UTR, splice junctions, coding sequence) of a reporter RNA in mammalian cell culture and testing the effects of single m5C sites on RNA metabolism and translation. For more information, visit our website or email: matthias.schaefer(at)meduniwien.ac.at

Kontakt-Person(en)

Haupt-Kontakt
Name: Matthias Schaefer

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