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Job-Art: Wissenschaftliche Jobausschreibungen

Master Thesis

Molecular Biology of Ovarian Cancer
Ebene 5Q, AKH Translational Gynecology Group, Department of Obstetrics and Gynecology, Medical University of Vienna



High grade serous ovarian cancers (HGSOC) account for about 75% of all ovarian carcinomas. Standard first-line treatment includes cytoreductive surgery and platinum-based chemotherapy. Most patients show primary response but the drugs often fail to suppress tumor growth by recurrence. Many patients die due to progression of disease. The 5-year survival rate is under 40%.


• to study molecular mechanisms underlying ovarian cancer progression

• to define genes/pathways as new therapeutic targets

• to develop specific therapies


• Forschungsbeihilfe nach MUW Schema (440€ monthly)


1 year, start in January 2018


Experimental techniques include genetics, gene expression and protein expression analysis of tumor cells (cell culture, RT-qPCR, Western blotting, cloning, fragment analysis, sequencing), IHC, IF, apoptosis assay, viability/survival assays, senescence assays.


Good basic knowledge of molecular biology, strong analytic capacity and commitment as well as interest in science.

Selected relevant publications:

• Kreuzinger C, Geroldinger A, Smeets D, Braicu EI, Sehouli J, Koller J, Wolf A, Darb-Esfahani S, Jöhrens K, Vergote I, Vanderstichele A, Boeckx B, Lambrechts D, Gabra H, Wisman GBA, Trillsch F, Heinze G, Horvat R, Polterauer S, Berns EMJJ, Theillet CG, Cacsire Castillo-Tong D. A complex network of tumor microenvironment in human high grade serous ovarian cancer. Clin Cancer Res. 2017 Oct 2. pii: clincanres.1159.2017. doi: 10.1158/1078-0432.CCR-17-1159. [Epub ahead of print]

• Flanagan JM, Wilson A, Koo C, Masrour N, Gallon J, Loomis E, Flower K, Wilhelm-Benartzi C, Hergovich A, Cunnea P, Gabra H, Braicu EI, Sehouli J, Darb-Esfahani S, Vanderstichele A, Vergote I, Kreuzinger C, Cacsire Castillo-Tong D, Wisman GB, Berns EM, Siddiqui N, Paul J, Brown R. Platinum-based chemotherapy induces methylation changes in blood DNA associated with overall survival in ovarian cancer patients. Clin Cancer Res. 23:2213-2222, 2017. doi: 10.1158/1078-0432.CCR-16-1754.

• Kreuzinger C, Gamperl M, Wolf A, Heinze G, Geroldinger A, Lambrechts D, Boeckx B, Smeets D, Horvat R, Aust S, Hamilton G, Zeillinger R, Cacsire Castillo-Tong D. Molecular characterization of 7 new established cell lines from high grade serous ovarian cancer. Cancer Lett. 362:218-28, 2015. doi: 10.1016/j.canlet.2015.03.040.


Name: Prof. Dan Cacsire Castillo-Tong
Telefon: +43-1-40400-78330

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