- Biochemistry and Structural biology
- Graz University of Technology
The Institute of Biochemistry at the Graz University of Technology is recruiting highly motivated PhD candidates.
Three open PhD positions are available in the research group of Gustav Oberdorfer. The groups primary research interests are designing and engineering of biomolecular structures and their functions - a multi-facetted effort that combines computational biology, structural biology, biochemistry and biophysics approaches. The PhD projects focus on designing and characterizing protein structures with central cavities or pores for passive transport and catalytic functionalization of de novo proteins.
Two PhD positions are to be filled in the research group of Andreas Winkler. The objectives revolve around an integrative structural biology approach addressing mechanisms of signal transduction in natural light-regulated enzymes. Understanding principles of sensor-effector modularity and how nature adapts them for diverse requirements, is key to improve success rates of artificial designs for the generation of optogenetic tools.
The group of Peter Macheroux is looking for one PhD student to work in the field of bacterial bioluminescence. Efficiency of light emission critically depends on the availability of the substrate molecule of the luciferase reaction. The enzymes involved in generating this compound form a large supramolecular complex. A detailed biochemical characterization combined with structural analyses will enable a better understanding of the underlying molecular details and facilitate the engineering of bioluminescent systems for in vivo imaging or optimized reporter systems.
All projects provide in-depth, interdisciplinary training in biomedical and biotechnological research in an international and stimulating environment.
The thesis projects follow an integrative approach and combine structural biology, enzymology, computational protein design and biophysics to decipher biosynthetic pathways, molecular mechanisms of catalysis and development of biomedical tools, employing a wide range of cutting-edge techniques.
Applicants must hold (or be close to obtaining) an undergraduate degree equivalent to a Master in any discipline of natural, life sciences or computer sciences. The ability to work in a team, initiative, flexibility as well as good organizational and learning skills are required. The selection procedure, all training activities and communications will be in English. Thus, excellent written and spoken English skills are required. Successful applicants will get employed for up to four years (initial contract for one year with the option of prolongation upon successful performance) with a contract that includes social benefits.
Applicants should send a CV, a one-page summary of their research experience and contact details of one referee until 9th of February 2019 to office.ibc(at)tugraz.at. Prospective starting dates throughout 2019. Detailed descriptions of the projects can be found here:
- Name: Institute of Biochemistry