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Job-Art: Wissenschaftliche Jobausschreibungen

PhD position in Oligonucleotide Synthesis

Fachgebiet
Nucleic Acid Chemistry/Bioorganic Chemistry
Arbeitsstätte
University of Vienna, Faculty of Chemistry
Website
Bewerbungsfrist
31.01.2021

Ausschreibungstext

The research group „Nucleic Acid Chemistry” at the Institute of Inorganic Chemistry of the University of Vienna is looking for a PhD candidate

 

to work on an organic/bioorganic chemistry project involving a novel approach for the chemical synthesis of RNA oligonucleotides at very high throughput using a photolithographic array fabrication process. The position is to be filled for a period of three years, starting right away.

 

ROLE WITHIN THE RESEARCH PROJECT

• Incorporate new photosensitive RNA phosphoramidites into oligonucleotides synthesized in situ by microarray photolithography

• Synthesize long RNA oligonucleotides at very high density

• Optimize synthetic parameters to reach RNA synthesis throughputs comparable to DNA synthesis

• Generate sequence permutations to study the binding properties of fluorogenic aptamers

• Participate in DNA and RNA library synthesis for gene assembly, sequencing and data storage applications

• Expand high-density array synthesis to chemically-modified nucleoside analogs

• Coordinate with collaboration partners

• Writing scientific articles and participation to symposiums/conferences

 

PROFILE

• MSc degree in bioorganic/organic chemistry (strongly preferred), biochemistry, synthetic/molecular biology

• Experience in the handling, preparation and analysis of nucleic acids is a strong asset (solid-phase synthesis, phosphoramidite chemistry, PCR, library preparation…)

• General understanding of sequencing methods, bioinformatics and programming is a plus

• Excellent command of written and spoken English. French and German are a plus

• Excellent teamwork and communication skills, independent, critical thinking and initiative

 

WORKING ENVIRONMENT AND CONDITIONS

• 30 h/week, salary corresponding to doctorant-level according to the FWF personnel costs (~€31000 brutto/year)

• A stimulating research environment, dedicated to problem-solving and opened to new ideas and hypotheses

• Access to the benefits and facilities of the University of Vienna, the largest research institution in Austria

 

ADDITIONAL INFORMATION

https://anorg-chemie.univie.ac.at/research/nucleic-acid-chemistry/

 

To apply, please send CV and motivation letter, as well as at least one letter of recommendation to Dr. Jory Lietard (jory.lietard(at)univie.ac.at) no later than 31/01/21.

 

Kontakt-Person(en)

Haupt-Kontakt
Name: Jory Lietard
Telefon: 00431427752643

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