PhD student (m/f/d) in Leukemia and Chromatin Biology
- Pediatric Leukemia
- St. Anna Kinderkrebsforschung / Children´s Cancer Research Institute
To strengthen our excellent research team, which is focused on the development and research of innovative approaches for the treatment of childhood cancer, we are looking for a PhD student (m/f/d) in leukemia and Chromatin Biology to join the group of Davide Seruggia. In this responsible role, you will have the unique opportunity to be part of a multidisciplinary competence center for pediatric oncology and to have a direct influence on the development of new cancer therapies.
The group (www.seruggialab.com) is interested in gene regulation in the context of pediatric cancer, and focuses on the study of non-coding regulatory sequences (enhancers) as well as protein complexes involved in the control of gene expression. We use genome editing (CRISPR screenings, CRISPRi/a, dense mutagenesis), chromatin profiling (ChIP-seq, CUT and RUN, ATAC-seq), proteomics, mouse models and computational approaches to identify and characterize cancer vulnerabilities. The project is funded by a Starting Grant from the ERC and will investigate how mutations at enhancers drive leukemia development and will elucidate the effect of sequence variation at transcription factor binding sites.
Relevant publications: Seruggia et al. Molecular Cell 2019; Sher, Hossain, Seruggia et al. Nature Genetics 2019; Seruggia et al. Scientific Reports 2020; Debruyne et al. Nature 2019; Seruggia et al Nucleic Acids Research 2015.
As a PhD student, you will
• Join an exciting, multi-disciplinary environment with lots of support for your personal and professional development from your supervisor, team, and peers
• Learn to take on ambitious research in close collaboration with experimental and clinical researchers. You will contribute from the start including planning of experiments and data acquisition. You will provide thorough and creative thinking that makes these projects a success
• Monitor the literature and community resources to keep abreast latest developments and to identify information, data, and methods to integrate in your own work
• Write papers, present your research at conferences, apply for fellowships, and contribute to grants
• Master’s degree in a relevant subject (molecular biology, cancer)
• Excellent technical skills (cell culture, nucleic acid isolation, qPCR)
• Curiosity and motivation to pursue an ambitious research agenda
• Excellent verbal and written communication skills in English (German not required)
• Self-motivated, enthusiastic and eager to learn
• Good team player, commitment, and creativity
• Scientific mindset, problem solving attitude
• An exciting project at the interface between medicine and biology
• A meaningful, inspiring, and international environment
• An outstanding working atmosphere in a strong team with excellent research and development opportunities
• Access to state-of-the-art infrastructure
• Great location in the center of Vienna, a capital of biomedical research in Europe with excellent quality of life
• A fair and attractive salary package according to the Austrian Science Fund FWF (https://www.fwf.ac.at/en/research-funding/personnel-costs/)
Who we are
The St. Anna Children’s Cancer Research Institute (CCRI), located in the center of Vienna, the world’s most livable city and one of Europe’s most important places for biomedical research and life sciences, is an international and multidisciplinary competence center striving to improve treatment of children and adolescents with cancer by connecting translational and clinical research with open-minded exploration of basic disease mechanisms. Through close cooperation between clinic and research, the CCRI provides an ideal environment for cutting-edge research and its translation into clinical practice. To achieve our ultimate goal of advancing the well-being of patients, the CCRI constantly pushes scientific boundaries and strongly promotes close collaboration and exchange with external institutions like the Medical University of Vienna, CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, the Institute of Molecular Biotechnology of the Austrian Academy of Sciences (IMBA) and the Institute of Molecular Pathology (IMP).
The CCRI is an equal opportunity employer. We value diversity and are committed to providing a work environment of mutual respect to everyone without regard to race, color, religion, national origin, age, gender identity or expression, disability, or any other characteristic protected by applicable laws, regulations and ordinances.
Please send your application via email to Davide Seruggia, application(at)ccri.at. Applications should at least contain your Curriculum Vitae, a cover letter, list of publications (please mark / explain your three top contributions), and the contact details of three references.
- Name: Davide Seruggia