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Job-Art: Wissenschaftliche Jobausschreibungen

PhD Position

Fachgebiet
Cancer Research
Arbeitsstätte
Medical University of Vienna/VetmedUni/FHWN and MedAustron Ion Therapy Center
Website
Bewerbungsfrist
28.02.2022
science4refugee

Ausschreibungstext

PAIR - Pre-clinicAl Ion beam Research

This PhD program offers training in the field of Proton and Carbon ion therapy for cancer treatment. Through enrolment in a four-year interdisciplinary program at the Medical University of Vienna, Austria, five students will work on innovative projects within a peer group and will receive broad training in ion beam research, thus training them for a career in academia, industry and beyond.

The FWF funded PAIR Doc.funds connect project links physics with cancer biology and bioinformatics to provide a systematic understanding of how ion therapy impacts cellular outcomes, including signal transduction and genome stability. This will be coupled with advanced ultra-high-field magnetic resonance imaging for better tumor characterization, both at the mechanistic and methodological levels.

The PAIR project aims to (1) link in-vitro and in-vivo molecular radiobiological approaches with functional/metabolic multiparametric imaging and radiomics analyses; (2) integrate 3D tumor models/spheroids and in-vivo models with subsequent systematic cellular analyses into genome stability, mutagenesis, transcriptional regulation and cell death.

 

Specific highlights of the program include:

• Student organized science days and international seminar series

• Dedicated thesis committees to guide the PhD student and project

• Strong collaboration and network between the interdisciplinary projects, including regular faculty and staff meetings

• Enrolment in the Doctoral PhD program N094 at the Medical University of Vienna, tailored to the thematic program of PAIR

• Funding that covers all research costs, work – related travel expenses, salary and health insurance for 4 years

 

PhD positions

Project 1 –Dosimetric aspects of image guided pre-clinical ion beam research

(contact Barbara Knäusl (barbara.knaeusl(at)meduniwien.ac.at), Medical University of Vienna, Department of Radiation Oncology for further information)

The aim is to establish and validate a full image guided workflow for small animal irradiation including a dosimetric framework for subsequent correlation of dose and linear energy transfer with functional imaging parameters as well as molecular parameters extracted from tissue slices.

 

Project 2 – Multiparametric MRI in pre-clinical research – medical physics aspects

(contact Dietmar Georg (dietmar.georg(at)meduniwien.ac.at), Medical University of Vienna, Department of Radiation Oncology for further information)

The overall goal of this project is to establish an optimal pre-clinical imaging workflow encompassing both morphologic and functional mp-MR imaging utilizing a 15.2 Tesla Ultra-high field MR scanner suitable to determine radiation effects after ion beam therapy.

 

Project 3 – Multiparametric MRI and radiomics approaches for in-vivo particle beam response assessment

(contact Markus Zeilinger (markus.zeilinger(at)fhwn.ac.at), University of Applied Sciences Wiener Neustadt, Faculty of Health for further information)

The aim is to decipher cancer heterogeneity and tackling the hypoxic tumor microenvironment (TME) challenge with functional and metabolic multiparametric MRI via an ultra-high field MRI and radiomics for tissue characterization and response assessment in ion beam research.

 

Project 4 - Biological effects of particle beam therapy on pancreatic cancer

(contact Corina Itze-Mayrhofer (corina.mayrhofer(at)vetmeduni.ac.at), University of Veterinary Medicine, Vienna, Institute of Animal Breeding and Genetics, IFA Tulln for further information)

The project aims to specify the cellular response of pancreatic cancer cells to particle beam therapy and to provide a broader understanding of the molecular basis of the PT-induced cellular signaling pathways.

 

Project 5 - Differential cellular responses to radiation

(contact Joanna Loizou (joanna.loizou(at)meduniwien.ac.at), Medical University of Vienna, Center for Cancer Research for further information)

The project aims to define the differential cellular responses to radiation using protons and Carbon ions with regard to the maintenance of genome stability. Changes in gene expression, DNA damage signaling and mutagenesis in different cell types will be determined in order to better understand differential cellular responses and outcomes to radiation.

 

Interdisciplinary faculty:

• Medical University of Vienna (Department of Radiation Oncology, Center for Cancer Research and Department of Biomedical Imaging and Image-guided Therapy)

• University of Veterinary Medicine, Vienna, Institute of Animal Breeding and Genetics, IFA Tulln

• University of Applied Sciences Wiener Neustadt, Faculty of Engineering and Health

 

Required qualifications:

• MSc or equivalent degree in biology, physics, computer science, data analysis, medicine or similar subject

• Good communication skills relevant for working in an international research and study group

• Research interest and ambitions for excellence in medical physics and signal transduction

• Fluent in English (oral and written)

• Analytical skills and ability to work independently on a project basis

 

General project and contact information

• Start of project: 01.05.2022

• Place of work: Institutes at respective universities (see above) and MedAustron Center for Ion Therapy, Wiener Neustadt for experiments

• Salary: 30hours/week (according to salary scheme of the Austrian science fund FWF)

• Closing date for application: 28.02.2022

 

Please submit your application including a CV and motivation letter to Christine Schibich (Christine.schibich@meduniwien.ac.at) indicating the project you apply for https://radioonkologie.meduniwien.ac.at/lehre/abschlussarbeiten/dissertationen/

 

Kontakt-Person(en)

Haupt-Kontakt
Name: Christine Schibich
Name: Barbara Knäusl
Name: Dietmar Georg
Name: Markus Zeilinger
Name: Corina Itze-Mayrhofer
Name: Joanna Loizou

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