Postdoctoral Fellow (Post-Doc)
- Epigenetics of the skin
- Marburg, Deutschland
- Closing Date
The PostDoc will be part of a team lead by Dr. Jacqueline Mermoud at the Institute of Molecular Biology and Tumorbiology (IMT) of the Philipps-University in Marburg which dissects the epigenetic basis of cell identity to understand its mis-regulation in disease, our emphasis is on chromatin regulation mediated by ATP dependent chromatin remodeling enzymes. The projects focus is on the epigenetic regulation in the skin driven by ATP dependent chromatin remodeling enzyme complex SMARCAD1. Humans carrying a mutation in a skin specific isoform of this remodeling enzyme lack fingerprints, which is manifested in diseases such as the immigration delay disease, yet, the cause of this phenotype is not understood. The successful candidate will thus determine how the remodeler SMARCAD1 functions in the skin and elucidate the molecular basis that underpins the establishment of fingerprints.
Starting Date and Period:
The position is funded by the VolkswagenStiftung for 1,5 years and is available immediately. The position may be extended beyond its initial funding period depending on a successful outcome.
The project employs next generation sequencing (NGS) methods including transcriptome profiling, genome wide chromatin immunoprecipitation coupled to Next Generation Sequencing (NGS) with subsequent bioinformatics as well as mechanistic and functional analysis of chromatin associated proteins, biochemistry and 3-D organotypic cultures.
• PhD (or equivalent) with a strong background in biochemistry, cell biology or molecular biology
• Experience in working with skin models
• Strong motivation, scientific curiosity and commitment to scientific excellence
• Experience in the following areas will be an asset: 3D organoids, iPS cells, bioinformatics, cell biology and biochemistry
• Ability to work independently
• English fluency (spoken and written)
• Excellent track record of research achievements and publications
• A well-developed research infrastructure with state of the art core facilities
• A research climate inviting lively, open and critical discussion within and across different fields of research.
• Close collaboration with a transregional, collaborative chromatin research network (DFG TRR81; Bad Nauheim, Giessen, Marburg, Rotterdam) aimed at obtaining a profound molecular understanding of chromatin changes in Differentiation and Malignancies.
• The Philipps-University promotes equal opportunity and provides a friendly, dynamic working environment characterized by professionalism and equality
• The Philipps-University and TRR81 provide a number of training opportunitues
Applicants should send their application bas a single PDF, including cover letter, CV, academic transcripts, and contact details of referees to mermoud(at)imt.uni-marburg.de. Deadline 10th of April 2020
- Main contact
- Name: Jacqueline Mermoud