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Job Type: Scientific Job Announcements

PhD Position in Immunology / Tumor Biology

Expertise
Immunology / Cancer Research / Molecular Biology
Workplace
Institute of Cancer Research, Medical University of Vienna
Website
Closing Date
20-07-2020

Content

We are looking for a highly motivated PhD student to join the “Translational Tumor Immunology” Lab of Dr. Dietmar Herndler-Brandstetter at the Institute of Cancer Research (Medical University of Vienna) (https://krebsforschung.meduniwien.ac.at/en/forschung-research/research-focus/cellular-and-molecular-tumorbiology/dietmar-herndler-brandstetter/).

 

We have recently generated long noncoding RNA (lncRNA) knockout mouse models using CRISPR/Cas9 to investigate the role of lncRNAs in T cell-mediated immunity (infection and cancer). By using state-of-the-art technologies (e.g. scRNA-seq, scATAC-seq, 13-color flow cytometry, in vivo transfer and disease models) you will have the opportunity to investigate the molecular mechanisms of lncRNA-mediated regulation of T cell differentiation and function.

 

YOUR PROFILE

+ M.Sc. or equivalent degree in immunology, molecular/cellular biology, pharmacy or a related discipline

+ High accuracy in scientific work and a proactive approach to solving problems

+ Excellent written and oral communication skills in English

+ High self-motivation and desire to work in an international research environment

+ Research experience with immunological, molecular and cellular biology methods is a plus

+ Research experience with mouse models is a plus

 

WE OFFER

+ Employment at the Medical University of Vienna for 3-4 years

+ Enrollment in the “Malignant Disease” or “Immunology” PhD program

+ Gross salary of approx. 30.870 EUR per year, according to the Austrian Science Fund (FWF): https://www.fwf.ac.at/en/research-funding/personnel-costs/

+ An international research environment that is friendly and collaborative

+ State-of-the-art technologies available at the Institute of Cancer Research and the Core Facilities of the Medical University of Vienna (NGS, Proteomics, Flow Cytometry/Cell Sorting, Imaging, Animal Research Center)

+ Support for the application of PhD fellowship programs and other funding opportunities for young researchers

 

APPLICATION DOCUMENTS

Interested candidates should send their application to: dietmar.herndler-brandstetter(at)meduniwien.ac.at, including the following documents:

- Curriculum Vitae

- Letter of motivation

- Abstract of your bachelor and master thesis

- Transcripts: BSc/MSc and school leaving exam (“Matura” and final school year)

- Names and contact details of 2 referees

 

SELECTED PUBLICATIONS

Developmental Plasticity of KLRG1+ Effector CD8+ T Cells Promotes Protective Immunity

Herndler-Brandstetter D*, Ishigame H*, Shinnakasu R, Plajer V, Stecher C, Zhao J, Lietzenmayer M, Kroehling L, Takumi A, Kometani K, Inoue T, Kluger Y, Kaech SM, Kurosaki T, Okada T, Flavell RA. Immunity (2018)

Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage anti-tumor activity

Guo Ring N*, Herndler-Brandstetter D*, Weiskopf K*, Shan L, Volkmer J, George BM, Lietzenmayer M, McKenna KM, Naik TJ, McCarthy A, Zheng Y, Ring AM, Flavell RA, Weissman IL. PNAS (2017)

Humanized mouse model supports development, function, and tissue residency of human natural killer cells

Herndler-Brandstetter D*, Shan L*, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Zheng Y, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Gurer C, MacDonald LE, Murphy AJ, Valenzuela DM, Yancopoulos GD, Montgomery RR, Flavell RA. PNAS (2017)

How aging affects T lymphocyte-mediated immunity

Herndler-Brandstetter D. Frontiers in Immunology (2013), Editorial

Mucosal memory CD8+ T cells are selected in the periphery by an MHC class I molecule

Huang Y, Park Y, Wang-Zhu Y, Larange A, Arens R, Bernardo I, Olivares-Villagómez D, Herndler-Brandstetter D, Abraham N, Grubeck-Loebenstein B, Schoenberger SP, Van Kaer L, Kronenberg M, Teitell MA, Cheroutre H. Nature Immunology (2011)

miR-17, miR-19b, miR-20a, and miR-106a are down-regulated in human aging

Hackl M, Brunner S, Fortschegger K, Schreiner C, Micutkova L, Mück C, Laschober GT, Lepperdinger G, Sampson N, Berger P, Herndler-Brandstetter D, Wieser M, Kühnel H, Strasser A, Rinnerthaler M, Breitenbach M, Mildner M, Eckhart L, Tschachler E, Trost A, Bauer JW, Papak C, Trajanoski Z, Scheideler M, Grillari-Voglauer R, Grubeck-Loebenstein B, Jansen-Dürr P, Grillari J. Aging Cell (2010)

Contact(s)

Main contact
Name: Dr. Dietmar Herndler-Brandstetter

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