PhD Position in Microplastic Research

A PhD thesis position for the EU funded Interreg project “MIND” is available under joint supervision by Prof. Dr. Lukas Kenner (Institute of Pathology, University of Veterinary Medicine Vienna) and Prof. Dr. Martin Wagner (FFoQSI).

Micro and nanoplastic particles (MNPs) represent a significant environmental burden and have been detected in numerous organisms and their tissues. Humans ingest an estimated 5 grams of MNPs per week via the gastrointestinal tract, including through contaminated food. However, the exact routes of contamination and health effects are still poorly understood. We have recently shown that MNPs can cross the gut- and the blood-brain-barrier. Still, it is unclear if and how they affect neurodegenerative diseases such as Alzheimer's disease (AD). The MIND project will investigate the food-dependent uptake of MNPs, their distribution in the body and their effects on neurodegenerative diseases in cooperation with the Institute of Neuroimmunology of the Slovak Academy of Sciences (NIU SAS).

The experimental focus of this work will be based on cell culture, transgenic animal studies with MNP feeding and investigation of human samples. Uptake of MNPs in cells and passage through the blood-brain barrier will be measured quantitatively and correlated to disease progression. Human FFPE samples will be studied using the OPTIR technology and linked to disease status.

We are seeking a highly motivated and flexible student with a strong interest in laboratory work and experience in cell- and molecular biology bench work. In addition, good communication skills and the ability to work in an interdisciplinary team are required.

Desired Skills and Experience:

• Master’s degree in Biology, Genetics, Molecular Biology, or a related field

• Standard molecular biology methods (PCR, sequencing, cloning, Western Blot, protein chemistry, CRISPR/Cas9 gene editing)

• Strong background in research, including experiments with cells (cell culturing, cell transfections and assays) and animals (mice)

• Lab management and organisation

• Excellent communication skills in English and German

• High motivation to work in an international team