Master Student

Master Student

Division Pharmacology

Head: Univ.-Prof. Dr. Dagmar Stoiber-Sakaguchi

Minor employment, 1 year position

The Karl Landsteiner University of Health Sciences (KL) is part of an academic and research community located at the Campus Krems, and includes a network of teaching hospitals in St. Pölten, Krems, Tulln and Eggenburg. The university offers degree programs in Human Medicine and Psychology which are tailored to the requirements of the Bologna model, opening the door to new, cutting-edge health professions. KL is committed to raising its profile in specific areas of biomedicine, biomedical engineering, and biopsychosocial sciences by entering into strategic academic and research partnerships with other institutions.

Information on the research project:

Aberrant activation of the Janus Kinase (JAK) / Signal Transducer and Activator of Transcription (STAT) pathway is commonly observed in various malignancies. Our research group investigates the role of STAT3 in acute myeloid leukemia (AML) cells. Notably, most patients with AML exhibit constitutive activation of STAT3, which is linked to adverse prognosis. However, current pharmacological approaches targeting JAK/STAT signaling have shown modest effectiveness. This project aims to evaluate the efficacy of different pharmacological strategies targeting JAK/STAT signaling (STAT3 degraders/inhibitors, JAK inhibitors,…).

The student will be primarily responsible for generating and maintaining primary leukemia cells as well as established cell lines. Additional tasks include conducting in vitro drug testing using various assays, performing molecular biology techniques (such as RT-qPCR and Western blotting), analyzing data, and assisting with routine laboratory duties.

Methods:

Molecular biology, cell culture, flow cytometry, histology

YOUR TASKS

Participation in the research projects at the Division Pharmacology (including Master thesis)

Development and conducting of in vitro (cell culture) models using molecular biology and immunological methods

YOUR PROFILE

Bachelor's degree in life sciences

Interest in science and in conducting a laboratory-based master thesis project

Preferred: Background in molecular biology, cell biology, immunology

Previous experience with cell culture and/or immunological methods will be considered as advantage

Friendly, open appearance and team spirit

YOUR PERSPECTIVE

You can expect a challenging job in an internationally visible and highly motivatedteam -we offer flexible working hours,

a paid lunch break, health care and many other benefits . The Karl Landsteiner University of Health Sciences is dedicated to achieving a balanced mix of male and female academic and non-academic staff. Consequently, applications from femalecandidates are particularly encouraged. People with disabilities who meet the required qualification criteria are expressly invited to apply and are given special consideration.

APPLICATION

Applications should include a motivation letter, curriculum vitae and credentials.

Please apply online at www.kl.ac.at/karriere with reference number “2510“ by 30.04.2025 at the latest.