PhD Position in Single-Molecule Biophysics (ERC-Funded)

The Molecular Biophysics Group, led by Dr. Georg Krainer at the Institute of Molecular Biosciences (IMB), University of Graz, Austria, is seeking a highly motivated and talented PhD candidate to join our team within the ERC Starting Grant project “SignAlloMod: Decoding the Molecular Logic of G Protein-Coupled Receptor (GPCR) Signaling.”

About the Position

This position focuses on developing advanced single-molecule approaches to study membrane receptor dynamics and interactions. The successful candidate will contribute to both methodological innovation and biological applications, including the investigation of GPCRs.

Key Responsibilities

The candidate will be responsible for the development and optimization of advanced single-molecule approaches, including platforms that integrate microfluidics. Key tasks include setup development, implementation of single-molecule fluorescence-based detection methods (e.g., confocal, TIRF), design and fabrication of microdevices, and the development of data acquisition and analysis software. This position offers the opportunity to work at the interface of biophysics, microtechnology, and quantitative biology, in close collaboration with team members specializing in GPCR biochemistry, experimental biophysics, and theoretical modeling.

Key Requirements

Applicants should hold (or be close to completing) a Master’s degree in Biophysics, Physics, Bioengineering, or a related field. A strong background in optics is desirable, along with proficiency in experimental design, quantitative data analysis, and programming (e.g., Python). Candidates should be highly motivated, capable of independent work, and eager to engage in interdisciplinary collaborations.

Preferred Qualifications

Experience with single-molecule fluorescence techniques (e.g., confocal microscopy, TIRF microscopy, and/or FRET-based methods) and/or microfluidic device fabrication is highly desirable. Familiarity with membrane protein biophysics or ligand-binding studies would be an advantage. A proven publication track record is desirable.

What We Offer

We offer a three-year PhD position (initial 1-year contract + 2-year extension), with the possibility of further extension based on project progress. The position includes a competitive salary and employment benefits under a fixed-term contract (75% FTE, 14-month salary) in accordance with Austrian academic standards, including paid annual leave. The successful candidate will have access to state-of-the-art facilities, including advanced single-molecule fluorescence instrumentation and microfluidic fabrication tools, all within a dynamic and collaborative research environment at the Institute of Molecular Biosciences (IMB). The position also provides opportunities for career development, international collaborations, and participation in conferences to present research findings.

How to Apply

Interested candidates should submit a single PDF file containing:

1. A cover letter outlining research interests, relevant expertise, and motivation for joining the project

2. A detailed CV, including academic achievements and relevant research experience

3. Contact information for 2–3 references

Applications should be sent to Dr. Georg Krainer at georg.krainer(at)uni-graz.at. The review of applications will begin immediately and will continue until the position is filled.

We are committed to fostering diversity and inclusion and encourage applications from all qualified individuals, regardless of gender, nationality, or background. We also welcome applications from motivated and talented candidates confident in their ability to excel, even if they do not meet every criterion.

Starting Date

As soon as possible or upon mutual agreement.

Additional Information

The University of Graz, one of Austria’s largest academic institutions, is committed to excellence in research and teaching. Researchers and students collaborate across fields to advance knowledge, tackle global challenges, and shape the future. The university fosters a supportive, inclusive, modern environment where achievement is valued and careers are nurtured.

The Institute of Molecular Biosciences (IMB) offers a dynamic, interdisciplinary research setting with state-of-the-art facilities for molecular biophysics, single-molecule research, and advanced biomolecular characterization. Situated in the vibrant city of Graz, the university provides an exceptional quality of life, a thriving scientific community, and outstanding opportunities for career development and international collaboration.

Our motto: We work for tomorrow. Join us!