PhD Position in Single-Molecule Microfluidics

The Molecular Biophysics Group, led by Prof. Georg Krainer at the Institute of Molecular Biosciences (IMB), University of Graz, Austria, is seeking a highly motivated and talented PhD candidate to join the ERC-funded project “SignAlloMod: Decoding the Molecular Logic of G Protein-Coupled Receptor (GPCR) Signaling”.

About the Position:

This role focuses on GPCR structure, dynamics, and interactions at the single-molecule level, combining biochemical, biophysical, and single-molecule approaches. Key tasks include:

•Expression & purification of GPCRs in insect/mammalian cells

•Reconstitution in nanodiscs/liposomes & functional characterization

•Development of single-molecule assays to study GPCR signaling mechanisms

Who Should Apply:

Candidates must have (or be near completion of) a Master’s degree in Biochemistry, Biophysics, Structural Biology, or a related field with expertise in:

•Protein biochemistry & purification of membrane proteins (preferably GPCRs), including protein expression in insect & mammalian systems (required)

•Experience in single-molecule methods and fluorescence spectroscopy is desirable

What We Offer:

•4-year fixed-term contract (1 + 3 years, 75% FTE, approx. 39,000 € gross/year)

•State-of-the-art facilities for single-molecule research and protein biochemistry

•Collaborative research environment & career development opportunities

How to Apply:

Send a single PDF to georg.krainer(at)uni-graz.at, including:

1.Cover letter (research interests & expertise)

2.CV & publication list

3.Contact info for 2–3 references

Applications are reviewed on a rolling basis until the position is filled.

Start Date: As soon as possible or upon mutual agreement.

Research Environment:

The University of Graz is one of Austria’s largest academic institutions, fostering a collaborative and innovative research environment. Situated in the vibrant city of Graz, the Institute of Molecular Biosciences (IMB) provides cutting-edge infrastructure for interdisciplinary research at the interface of biophysics, biochemistry, and molecular biology. Our motto: We work for tomorrow.