PhD Position in Single-Molecule Microfluidics for Cancer Diagnostics (UFO-Funded)

The Molecular Biophysics Group, led by Dr. Georg Krainer at the Institute of Molecular Biosciences (IMB), University of Graz, Austria, is seeking a highly motivated and talented PhD candidate to join our team within the UFO Award project “HER2 Profiling in Solid Tumors”. This is a joint project performed together with the group of Prof. Sandro Keller, Institute of Molecular Biosciences (IMB), University of Graz.

About the Position

This position focuses on developing a single-molecule microfluidic assay for cancer diagnostics, with an emphasis on detecting and quantifying HER2 biomarker levels in solid tumors. The successful candidate will integrate native nanodisc technology, microfluidics, and single-molecule fluorescence techniques to establish a highly sensitive diagnostic biomarker platform.

Key Responsibilities

Key Responsibilities include working with native membrane-protein libraries derived from cancer cells using nanodisc-forming polymers, designing and fabricating microfluidic devices, integrating fluorescence-based single-molecule detection techniques into an efficient assay workflow, and performing quantitative data analysis. The project will be conducted in close collaboration with the Keller group, leveraging their expertise in native nanodisc technologies and native membrane protein library production.

Key Requirements

Applicants should hold (or be close to completing) a Master’s degree in Biochemistry, Bioengineering, Biophysics, or a related field. A background in assay development and cell biology is highly desirable, along with proficiency in quantitative data analysis. Candidates should be highly motivated, capable of independent work, and eager to engage in interdisciplinary collaborations.

Preferred Qualifications

Experience with nanodisc technology, single-molecule fluorescence techniques and/or microfluidics would be an advantage.

What We Offer

We offer a three-year PhD position (initial 1-year contract + 2-year extension), with the possibility of further extension based on project progress. The position includes a competitive salary and employment benefits under a fixed-term contract (75% FTE, 14-month salary) in accordance with Austrian academic standards, including paid annual leave. The successful candidate will have access to state-of-the-art facilities, including cell culture facilities, advanced single-molecule fluorescence instrumentation and microfluidic fabrication tools, all within a dynamic and collaborative research environment at the Institute of Molecular Biosciences (IMB). The position also provides opportunities for career development, international collaborations, and participation in conferences to present research findings.

How to Apply

Interested candidates should submit a single PDF file containing:

1. A cover letter outlining research interests, relevant expertise, and motivation for joining the project

2. A detailed CV, including academic achievements and relevant research experience

3. Contact information for 2–3 references

Applications should be sent to Dr. Georg Krainer at georg.krainer(at)uni-graz.at. The review of applications will begin immediately and will continue until the position is filled.

We are committed to fostering diversity and inclusion and encourage applications from all qualified individuals, regardless of gender, nationality, or background. We also welcome applications from motivated and talented candidates confident in their ability to excel, even if they do not meet every criterion.

Starting Date

As soon as possible or upon mutual agreement.

Additional Information

The University of Graz, one of Austria’s largest academic institutions, is committed to excellence in research and teaching. Researchers and students collaborate across fields to advance knowledge, tackle global challenges, and shape the future. The university fosters a supportive, inclusive, modern environment where achievement is valued and careers are nurtured.

The Institute of Molecular Biosciences (IMB) offers a dynamic, interdisciplinary research setting with state-of-the-art facilities for molecular biophysics, single-molecule research, and advanced biomolecular characterization. Situated in the vibrant city of Graz, the university provides an exceptional quality of life, a thriving scientific community, and outstanding opportunities for career development and international collaboration.

Our motto: We work for tomorrow. Join us!