PhD position - "Mechanics at focal adhesions - towards mechanodiagnostics and -therapeutics"

Job Description

Have you ever wondered how cells respond to forces and how this response can be measured, characterized and utilized? Join the Department of Biomolecular and Selforganizing Matter and develop mechanodiagnostic and mechanotherapeutic tools. We have established a library of mechanically calibrated and tuneable coiled coils. To expand our existing coiled coil library, you will design and prepare new molecular building blocks and characterize their mechanical properties. You will then apply these building blocks as molecular force sensors for measuring cell-generated forces in 2D and 3D cultures of healthy and diseased cells. The project is highly interdisciplinary and ranges from the design of coiled coil-based molecular force sensors and their mechanical characterization with single-molecule force spectroscopy to live cell imaging. Depending on your interests, the project can be tailored towards force sensor design, biophysical characterization or cell biology applications.

Requirements

You have a Master’s degree in Biophysics, Biomaterials, Biomedical Engineering, Molecular or Cell Biology. Besides having a strong background in at least one of the above-mentioned areas, you aim to expand your knowledge and learn and develop the other techniques. The project involves collaborations with other groups within the doc.funds doctoral network Molecular Transport and Recognition as well as a number of external partners. You should have a strong interest in a multidisciplinary, collaborative approach. Independent thinking, communication and team spirit are crucial for the successful development of the project.

Johannes Kepler University is committed to promoting equality and diversity. We welcome applicants from all sections of the community, regardless of gender, ethnicity, disability or sexual orientation. Our department fosters a supportive atmosphere that encourages individuals to be themselves, share their experiences, and learn from one another, creating a conducive setting for innovative and impactful research.

Your application

The position will start in September 2025.

Please submit your application on academicpositions.com.

The application deadline is 31.05.2025