Postdoctoral Research Position in GPCR Biochemistry & Biophysics (ERC-Funded)

The Molecular Biophysics Group, led by Dr. Georg Krainer at the Institute of Molecular Biosciences (IMB), University of Graz, Austria, is seeking a highly motivated and talented Postdoctoral Researcher to join our team within the ERC Starting Grant project “SignAlloMod: Decoding the Molecular Logic of G Protein-Coupled Receptor (GPCR) Signaling.”

About the Position

This position focuses on the biochemistry and biophysics of GPCRs, with a particular emphasis on investigating their structure, dynamics, and interactions at the single-molecule level. The successful candidate will contribute to advancing our understanding of GPCR signaling mechanisms through cutting-edge biophysical methodologies.

Key Responsibilities

Key responsibilities include the design, expression, and purification of GPCRs and transducer proteins using insect and mammalian cell systems as well as the biochemical characterization and functional reconstitution of GPCRs in model membrane systems such as native nanodiscs and liposomes. Another key aspect of the role will be the development and implementation of single-molecule assays, including single-molecule fluorescence and microfluidic approaches, to investigate GPCR structure, interactions, and dynamics. Additionally, the candidate will collaborate with team members to integrate experimental data with theoretical modeling.

Key Requirements

Applicants should hold a Ph.D. in Biochemistry, Biophysics, Structural Biology, or a related field and demonstrate strong expertise in GPCR biochemistry and membrane protein purification, including experience with protein expression in insect and mammalian cell systems. Hands-on experience with biophysical methods such as fluorescence spectroscopy or other advanced tools for studying GPCRs and membrane proteins is highly desirable. A solid understanding of membrane protein structure, dynamics, and function is essential, along with the ability to independently design and execute experiments, analyze data, and present results. Candidates should also have a strong track record, including first-author publications in peer-reviewed journals, excellent communication skills, and a collaborative, interdisciplinary mindset.

Preferred Qualifications

Experience with single-molecule techniques, such as confocal and TIRF microscopy, single-molecule FRET, or related methods, is desirable. Expertise in membrane protein reconstitution using nanodiscs is advantageous, as is prior research on ligand-binding studies or the structural characterization of GPCRs.

What We Offer

We offer a two-year full-time position, with the possibility of extension based on project progress, under a fixed-term, full-time contract (100% FTE, 14-month salary) in accordance with Austrian academic standards, including paid annual leave. The successful candidate will have access to state-of-the-art protein purification infrastructure and cutting-edge single-molecule fluorescence instrumentation. The position also provides opportunities for career development, international collaborations, and participation in conferences to present research findings.

How to Apply

Interested candidates should submit a single PDF file containing:

1. A cover letter outlining research interests, relevant expertise, and motivation for joining the project.

2. A detailed CV, including a list of publications.

3. Contact information for 2–3 references.

Applications should be sent to Dr. Georg Krainer at georg.krainer@uni-graz.at. The review of applications will begin immediately and will continue until the position is filled.

We are committed to fostering diversity and inclusion and encourage applications from all qualified individuals, regardless of gender, nationality, or background. We also welcome applications from motivated and talented candidates confident in their ability to excel, even if they do not meet every criterion.

Starting Date

As soon as possible or upon mutual agreement.

Additional Information

The University of Graz, one of Austria’s largest academic institutions, is committed to excellence in research and teaching. Researchers and students collaborate across fields to advance knowledge, tackle global challenges, and shape the future. The university fosters a supportive, inclusive, modern environment where achievement is valued and careers are nurtured.

The Institute of Molecular Biosciences (IMB) offers a dynamic, interdisciplinary research setting with state-of-the-art facilities for molecular biosciences and single-molecule research. Situated in the vibrant city of Graz, the university provides an exceptional quality of life, a thriving scientific community, and outstanding opportunities for career development and international collaboration.

Our motto: We work for tomorrow. Join us!