Stem cell modulation in neural development and regeneration
Stem cell modulation in neural development and regeneration
Disciplines
Biology (100%)
Keywords
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Tissue Growth,
Neural Tube,
Pattern Formation,
Morphogen
Organs in our body are kept alive by so-called stem cells. Stem cells are unique because they can self renew, a property that allows them to create identical copies of themselves but at the same time also generate more specialized cells that fulfil important tasks in the various organs. By doing so, they keep alive for a long time and constantly replace dying or damaged cells. In our brain and spinal chord, however, the situation is slightly different. Here, huge numbers of highly specialized nerve cells fulfil very specific tasks, sometimes activating, sometimes inhibiting the neural circuits in our central nervous system. How do the stem cells know what type of neuron to generate at which position and at what point in time? How do they change in space and time so they can create the correct types of neurons? Understanding the mechanisms that regulate neural stem cells in space and time, finding out how the stem cell state is modulated despite the need for constant self-renewal is the key goal of our SFB. Our consortium combines numerous approaches centered around a few key enabling technologies to address this problem from a variety of different angles. We employ a number of different models ranging from sea-worms all the way to human 3D cell cultures. We focus on single-cell technologies that allow us to precisely follow stem cells in space and time. Our consortium is grouped around a central bio-informatics hub that allows us to maximise the interpretation and correlation of the various datasets. Together, we intend to build a central hub for neural stem cell biology in Austria that addresses a unique unifying biological question using cutting edge technologies at the forefront of what is technologically possible.
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2024 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2024 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2020 -)
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consortium member (01.03.2024 -)
- IMBA – Institut für Molekulare Biotechnologie GmbH
- Daniela D. Pollak-Monje Quiroga, Medizinische Universität Wien , national collaboration partner
- Guillaume Balavoine, Université Paris Diderot - Paris 7 - France
- Ana Martin-Villalba, Deutsches Krebsforschungszentrum - Germany
- Andreas Trumpp, Deutsches Krebsforschungszentrum Heidelberg - Germany
- Florian Heyd, Freie Universität Berlin - Germany
- Wolfgang Enard, Ludwig-Maximilians-Universität München - Germany
- Barbara Treutlein, Max-Planck-Gesellschaft - Germany
- Kent Duncan, Universität Hamburg - Germany
- Cesare Indiveri, Università di Calabria - Italy
- Jens C. Schwamborn, Université du Luxembourg - Luxembourg
- Andras Simon, Karolinska Institute - Sweden
- Rolf Zeller, University of Bern - Switzerland
- Matthias Lütolf, École polytechnique fédérale de Lausanne - Switzerland
- Ahmet Okay Caglayan, Istanbul Bilim University - Turkey
- Fritz J. Sedlazeck, Baylor College of Medicine - USA
- Molly M. Stevens, Imperial College of London - United Kingdom
- Stefano Pluchino, University of Cambridge - United Kingdom
Research Output
- 407 Citations
- 47 Publications
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2025
Title Adeno-associated viruses for efficient gene expression in the axolotl nervous system DOI 10.1073/pnas.2421373122 Type Journal Article Author Lust K Journal Proceedings of the National Academy of Sciences Link Publication -
2025
Title ß-catenin-driven endomesoderm specification is a Bilateria-specific novelty DOI 10.1038/s41467-025-57109-w Type Journal Article Author Lebedeva T Journal Nature Communications Pages 2476 Link Publication -
2024
Title Molecular circadian rhythms are robust in marine annelids lacking rhythmic behavior DOI 10.1371/journal.pbio.3002572 Type Journal Article Author Häfker N Journal PLOS Biology Link Publication -
2025
Title SOX2+ sustentacular cells are stem cells of the postnatal adrenal medulla DOI 10.1038/s41467-024-55289-5 Type Journal Article Author Kemkem Y Journal Nature Communications -
2025
Title Probing Cell-Type Specificity of Mutant Phenotype at Transcriptomic Level Using Mosaic Analysis with Double Markers (MADM). DOI 10.1007/978-1-0716-4310-5_7 Type Journal Article Author Cheung G Journal Methods in molecular biology (Clifton, N.J.) Pages 139-151 -
2025
Title Guiding Light: Mechanisms and Adjustments of Environmental Light Interpretation with Insights from Platynereis dumerilii and Other Selected Examples DOI 10.2108/zs240099 Type Journal Article Author Wulf P Journal Zoological Science -
2025
Title A cost- and time-efficient method for high-throughput cryoprocessing and tissue analysis using multiplexed tissue molds DOI 10.1016/j.crmeth.2025.101023 Type Journal Article Author Reumann D Journal Cell Reports Methods Pages 101023 Link Publication -
2025
Title Advancing autism research: Insights from brain organoid modeling DOI 10.1016/j.conb.2025.103030 Type Journal Article Author Li C Journal Current Opinion in Neurobiology Pages 103030 Link Publication -
2025
Title The role of microheterogeneity in cell fate decisions in neural progenitors and neural crest DOI 10.1016/j.conb.2025.103031 Type Journal Article Author Kamenev D Journal Current Opinion in Neurobiology Pages 103031 Link Publication -
2025
Title How radial glia progenitor lineages generate cell-type diversity in the developing cerebral cortex DOI 10.1016/j.conb.2025.103046 Type Journal Article Author Pipicelli F Journal Current Opinion in Neurobiology Pages 103046 Link Publication -
2023
Title Odontodes: The Developmental and Evolutionary Building Blocks of Dentitions Type Book Author Chen Donglei Publisher Taylor & Francis Ltd -
2023
Title The promise of genetic screens in human in vitro brain models DOI 10.1515/hsz-2023-0174 Type Journal Article Author Beirute-Herrera J Journal Biological Chemistry Pages 13-24 Link Publication -
2024
Title Single-cell Profiling of Reprogrammed Human Neural Stem Cells Unveils High Similarity to Neural Progenitors in the Developing Central Nervous System DOI 10.1007/s12015-024-10698-3 Type Journal Article Author Spathopoulou A Journal Stem Cell Reviews and Reports Pages 1325-1339 Link Publication -
2024
Title Assessing the precision of morphogen gradients in neural tube development DOI 10.1038/s41467-024-45148-8 Type Journal Article Author Zagorski M Journal Nature Communications Pages 929 Link Publication -
2024
Title Adeno-associated viral tools to trace neural development and connectivity across amphibians DOI 10.1016/j.devcel.2024.10.025 Type Journal Article Author Jaeger E Journal Developmental Cell Link Publication -
2024
Title Self-organized pattern formation in the developing mouse neural tube by a temporal relay of BMP signaling DOI 10.1016/j.devcel.2024.10.024 Type Journal Article Author Lehr S Journal Developmental Cell Link Publication -
2024
Title Applying single-cell and single-nucleus genomics to studies of cellular heterogeneity and cell fate transitions in the nervous system DOI 10.1038/s41593-024-01827-9 Type Journal Article Author Adameyko I Journal Nature Neuroscience Pages 2278-2291 -
2024
Title Protocol for fabricating elastomeric stencils for patterned stem cell differentiation DOI 10.1016/j.xpro.2024.103187 Type Journal Article Author Lehr S Journal STAR Protocols Pages 103187 Link Publication -
2024
Title Modeling early phenotypes of Parkinson’s disease by age-induced midbrain-striatum assembloids DOI 10.1038/s42003-024-07273-4 Type Journal Article Author Barmpa K Journal Communications Biology Pages 1561 Link Publication -
2024
Title Alternative lengthening of telomere-based immortalization renders H3G34R-mutant diffuse hemispheric glioma hypersensitive to PARP inhibitor combination regimens DOI 10.1093/neuonc/noae228 Type Journal Article Author Laemmerer A Journal Neuro-Oncology Pages 811-827 Link Publication -
2024
Title Reconstitution of Human Brain Cell Diversity in Organoids via Four Protocols DOI 10.1101/2024.11.15.623576 Type Preprint Author Naas J Pages 2024.11.15.623576 Link Publication -
2024
Title Molecular profiles, sources and lineage restrictions of stem cells in an annelid regeneration model DOI 10.1038/s41467-024-54041-3 Type Journal Article Author Stockinger A Journal Nature Communications Pages 9882 Link Publication -
2024
Title Protocol for mapping cell lineage and cell-type identity of clonally-related cells in situ using MADM-CloneSeq DOI 10.1016/j.xpro.2024.103168 Type Journal Article Author Cheung G Journal STAR Protocols Pages 103168 Link Publication -
2024
Title Protocol for quantitative reconstruction of cell lineage using mosaic analysis with double markers in mice DOI 10.1016/j.xpro.2024.103157 Type Journal Article Author Cheung G Journal STAR Protocols Pages 103157 Link Publication -
2024
Title The chromatin regulator Ankrd11 controls cardiac neural crest cell-mediated outflow tract remodeling and heart function DOI 10.1038/s41467-024-48955-1 Type Journal Article Author Kibalnyk Y Journal Nature Communications Pages 4632 Link Publication -
2024
Title Motor innervation directs the correct development of the mouse sympathetic nervous system DOI 10.1038/s41467-024-51290-0 Type Journal Article Author Erickson A Journal Nature Communications Pages 7065 Link Publication -
2024
Title Joint single-cell genetic and transcriptomic analysis reveal pre-malignant SCP-like subclones in human neuroblastoma DOI 10.1186/s12943-024-02091-y Type Journal Article Author Olsen T Journal Molecular Cancer Pages 180 Link Publication -
2024
Title Time me by the moon DOI 10.1038/s44319-024-00196-5 Type Journal Article Author Ritter A Journal EMBO Reports Pages 3169-3176 Link Publication -
2024
Title Lineage tracing of Shh+ floor plate cells and dynamics of dorsal–ventral gene expression in the regenerating axolotl spinal cord DOI 10.1111/dgd.12945 Type Journal Article Author Arbanas L Journal Development, Growth & Differentiation Pages 414-425 Link Publication -
2024
Title Dynamics of morphogen source formation in a growing tissue DOI 10.1371/journal.pcbi.1012508 Type Journal Article Author Ho R Journal PLOS Computational Biology Link Publication -
2024
Title Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis DOI 10.1101/2024.09.20.614050 Type Preprint Author Vijatovic D Pages 2024.09.20.614050 Link Publication -
2024
Title A polarized FGF8 source specifies frontotemporal signatures in spatially oriented cell populations of cortical assembloids DOI 10.1038/s41592-024-02412-5 Type Journal Article Author Bosone C Journal Nature Methods Pages 2147-2159 Link Publication -
2020
Title The Still Dark Side of the Moon: Molecular Mechanisms of Lunar-Controlled Rhythms and Clocks DOI 10.1016/j.jmb.2020.03.009 Type Journal Article Author Andreatta G Journal Journal of Molecular Biology Pages 3525-3546 Link Publication -
2020
Title A human tissue screen identifies a regulator of ER secretion as a brain-size determinant DOI 10.1126/science.abb5390 Type Journal Article Author Esk C Journal Science Pages 935-941 Link Publication -
2024
Title Morphological Analysis of Neurons and Glia Using Mosaic Analysis with Double Markers; In: Neuronal Morphogenesis - Methods and Protocols DOI 10.1007/978-1-0716-3969-6_19 Type Book Chapter Publisher Springer US -
2024
Title A framework for neural organoids, assembloids and transplantation studies DOI 10.1038/s41586-024-08487-6 Type Journal Article Author Arlotta P Journal Nature -
2024
Title Dynamic microvilli sculpt bristles at nanometric scale DOI 10.1038/s41467-024-48044-3 Type Journal Article Author Ikeda K Journal Nature Communications Pages 3733 Link Publication -
2024
Title Cerebral organoids display dynamic clonal growth and tunable tissue replenishment DOI 10.1038/s41556-024-01412-z Type Journal Article Author Lindenhofer D Journal Nature Cell Biology Pages 710-718 Link Publication -
2024
Title ARID1B controls transcriptional programs of axon projection in an organoid model of the human corpus callosum DOI 10.1016/j.stem.2024.04.014 Type Journal Article Author Martins-Costa C Journal Cell Stem Cell Link Publication -
2024
Title Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue DOI 10.1136/gutjnl-2023-331532 Type Journal Article Author Jevans B Journal Gut Pages 1441-1453 Link Publication -
2024
Title Mouse neural tube organoids self-organize floorplate through BMP-mediated cluster competition DOI 10.1016/j.devcel.2024.04.021 Type Journal Article Author Krammer T Journal Developmental Cell Link Publication -
2024
Title Increased cholesterol synthesis drives neurotoxicity in patient stem cell-derived model of multiple sclerosis. DOI 10.1016/j.stem.2024.09.014 Type Journal Article Author Ionescu Rb Journal Cell stem cell -
2024
Title Neutral competition explains the clonal composition of neural organoids DOI 10.1371/journal.pcbi.1012054 Type Journal Article Author Pflug F Journal PLOS Computational Biology Link Publication -
2023
Title Protocol for sorting cells from mouse brains labeled with mosaic analysis with double markers by flow cytometry DOI 10.1016/j.xpro.2023.102771 Type Journal Article Author Amberg N Journal STAR Protocols Pages 102771 Link Publication -
2023
Title Multipotent progenitors instruct ontogeny of the superior colliculus DOI 10.1016/j.neuron.2023.11.009 Type Journal Article Author Cheung G Journal Neuron Link Publication -
2021
Title Autophagy in a-Synucleinopathies—An Overstrained System DOI 10.3390/cells10113143 Type Journal Article Author Fellner L Journal Cells Pages 3143 Link Publication -
2021
Title Neurotransmitter signaling regulates distinct phases of multimodal human interneuron migration DOI 10.15252/embj.2021108714 Type Journal Article Author Bajaj S Journal The EMBO Journal Link Publication