Functional heterogeneity of mesenchymal stromal cells

The bone marrow is responsible for blood formation and the maturation of immune system cells. The supporting cells of the bone marrow, so-called stromal cells, play an important role in these processes. However, stromal cells also have tissue regenerative and immune- regulating properties, which is why stromal cells are of interest for numerous clinical applications. In this research project, we investigate which types of stromal cells are responsible for the many different functions. This should shed light on which types of stromal cells are best suited for different clinical applications. Using the latest sequencing and analysis technologies, our interdisciplinary research team will create a detailed functional map of stromal cells in mice and humans. The findings from this basic research project may also be relevant for cancer research, as different types of stromal cells also occur in the tumor and strongly influence the immune cells and the formation of metastases.