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NR2F6 intrinsic role in anti-tumor NK cell responses

NR2F6 intrinsic role in anti-tumor NK cell responses

Natascha Kleiter (ORCID: 0000-0003-4389-9813)
  • Grant DOI 10.55776/PAT6014624
  • Funding program Principal Investigator Projects
  • Status ongoing
  • Start February 1, 2025
  • End January 31, 2029
  • Funding amount € 470,140
  • Project website
  • E-mail

Matching Funds - Tirol

Disciplines

Clinical Medicine (20%); Medical-Theoretical Sciences, Pharmacy (80%)

Keywords

    Nuclear receptor NR2F6, NK cell, Tumor, Anti-Tumor Immune Responses

Abstract

The focus of cancer immunotherapy primarily lies on the adaptive, targeted immune response, where CD8- and CD4-positive T-lymphocytes play a central role due to their ability to respond specifically to antigens. However, increasing attention is being directed toward natural killer (NK) cells, which are part of the innate immune system, in tumor control. NK cells provide a rapid and natural defense against altered self-cells, serving as a critical first line of defense in combating infectious diseases and cancer. Moreover, NK cells can inhibit the spread of cancer cells from the primary tumor to other organs, thereby limiting metastasis. Nevertheless, NK cells often lose their effectiveness once they infiltrate a tumor. We have identified a key molecule that suppresses NK cell activity in tumor defense. The biological function of this hormone receptor in NK cells remains unclear. Preliminary results from preclinical mouse models, however, suggest that it plays an essential role in tumor rejection. Animals lacking this hormone receptor exhibit significantly more efficient NK cell-dependent rejection of tumors and lung metastases compared to control animals. Our research project aims to investigate in detail how the targeted loss of the hormone receptor in NK cells affects their development and function. In the next phase, we intend to analyze the anti-tumor activity of NK cells during tumor growth and metastasis in the presence and absence of immune checkpoint inhibition. As a critical translational step, this hormone receptor will ultimately be knocked out in the human NK-92 cell line as well as in primary human NK cells to study the functional effects during tumor growth in both tissue cultures and immunodeficient mice. We hope that future immunotherapies targeting the suppression of this hormone receptor`s function in NK cells will present an effective strategy to prevent tumor growth and metastasis.

Research institution(s)
  • Medizinische Universität Innsbruck - 100%
Project participants
  • Zlatko Trajanoski, Medizinische Universität Innsbruck , national collaboration partner
  • Veronika Sexl, Universität Innsbruck , national collaboration partner
International project participants
  • Chiara Romagnani, Deutsches Rheuma-Forschungszentrum Berlin - Germany

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