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untangling

untangling

Christian Zimmermann (ORCID: 0000-0002-6440-2100)
  • Grant DOI 10.55776/P35642
  • Funding program Principal Investigator Projects
  • Status ongoing
  • Start October 1, 2022
  • End October 31, 2026
  • Funding amount € 394,839
  • E-mail

Disciplines

Biology (80%); Computer Sciences (20%)

Keywords

    Gene expression, Morphological plasticity, Aureobasidium pullulans, Transcriptomics, Proteomics, Bioinformatics

Abstract

What make the yeast go round? Vienna, Austria. While most fungi grow as a network of thin threads (hyphae), yeasts have a spherical shape and grow as individual cells (unicellular). Some special fungi can grow both as connected hyphae and unicellular. These so-called yeast-like fungi switch between those two forms depending on the surroundings. This switch influences several properties such as stress resistance and the production of valuable substances. In a new project, a young science team researches how exactly the yeast-like fungi can switch between the two forms. Fungi of the genus Aureobasidium can be found on the leaves and fruits of several plants around the globe, but also in extreme environments such as glacial and polar ice, salt lakes, and even on old plastics. These fungi can be used as biocontrol agents, this means, they populate plants and protect them from harmful bacteria and molds. Aurebasidium species also produce some valuable substance, such as antibiotics or different polymers that might be alternatives for artificial plastics. Notably, the cell shape plays an important role during the applications in agriculture and industry. Aurebasidium fungi are yeast-like fungi and can switch between unicellular growth and growth as hyphae. In a new project, a young science team under the lead of Christian Derntl, wants to find out how exactly these fungi are switching between these two forms. The scientists are interested in the regulatory mechanisms, gene, and proteins involved in the morphological switch. The team expects new findings about the basic biology of these fungi and leads to improve the application potential in agriculture and industry. Contact: Christian Derntl, christian.derntl@tuwien.ac.at

Research institution(s)
  • Technische Universität Wien - 100%
Project participants
  • Andreas Rauber, Technische Universität Wien , national collaboration partner
  • Bernhard Lendl, Technische Universität Wien , national collaboration partner
  • Ruth Birner-Grünberger, Technische Universität Wien , national collaboration partner
  • Thomas Gärtner, Technische Universität Wien , national collaboration partner
International project participants
  • Florian Freimoser, Agroscope - Switzerland

Research Output

  • 6 Citations
  • 2 Publications
Publications
  • 2024
    Title Bi-directionalized promoter systems allow methanol-free production of hard-to-express peroxygenases with Komagataella Phaffii
    DOI 10.1186/s12934-024-02451-9
    Type Journal Article
    Author Besleaga M
    Journal Microbial Cell Factories
    Pages 177
    Link Publication
  • 2023
    Title Evaluation of reference genes for transcript analyses in Komagataella phaffii (Pichia pastoris)
    DOI 10.1186/s40694-023-00154-1
    Type Journal Article
    Author Besleaga M
    Journal Fungal Biology and Biotechnology
    Pages 7
    Link Publication

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