The Unit of Laboratory Animal Pathology at the University of Veterinary Medicine of Vienna is looking for a passionate and highly motivated master student interested in deciphering the function of the histone methyltransferase KMT2C in prostate cancer.
KMT2C is one of the most frequently mutated genes in prostate cancer, however the molecular consequences of these mutations are largely unexplored. We have recently shown that the catalytic domain of KMT2C is essential to suppress malignant transformation in a prostate cancer mouse model and in human patient datasets (Limberger, T., et al., KMT2C methyltransferase domain regulated INK4A expression suppresses prostate cancer metastasis. Mol Cancer, 2022. 21(1): p. 89. By using CRISPR based prime editing, the aim of this project is to further characterize the KMT2C mutational landscape in human prostate cancer cell lines and organoid cell culture systems. The methods used in this project will involve molecular cloning of CRISPR vectors, RNA/DNA and protein based methods and tissue culture systems.
The master student will be integrated in a highly cooperative, supportive team with a friendly working environment. Besides the affiliation with the Veterinary University of Vienna, the master student will also have close collaboration with the Institute of Pathology at the Medical University of Vienna.
We are looking for a creative and motivated master student with a strong interest in molecular biology and who is interested in expanding her/his skills in the field of cancer research. Experience in basic tissue culture techniques and molecular biology would be advantageous. Students with a Bachelor's degree in molecular biology, genetics or a related discipline are welcome to apply. Furthermore, the dedicated master student should be a team player and be able to communicate in English as we are an international research group.
Duration is 12 months.
Starting date is as soon as possible (within the next three months).
The master thesis project includes a monthly scholarship according to the scales of the Austrian Science Fund FWF.
If you are interested to apply in order to become part of our team and to work in an outstanding research environment, you are welcome to submit your application including a CV and a motivation letter.
01. Februar 2024
31. Jänner 2024