PhD opportunity – Pharmacology of Opioid Peptides

We are looking for biochemists, pharmacologists or medicinal chemists. The selected candidate(s) will engage in a unique and innovative set-up of peptide chemistry, peptidomics, receptor signaling and preclinical clinical expertise to effectively design and develop novel peptide-based drug candidates for the κ-opioid receptor and other G protein-coupled receptors (GPCRs). The project focuses on the pharmacology of stabilized and circular peptides at GPCRs, with a focus on the κ-opioid receptor. It includes chemical synthesis and stability assays of peptides, structural analysis of compound(s) alone and in complex with the receptor, detailed in vitro receptor pharmacology, peptide biodistribution and in vivo proof-of-concept studies in relevant animal models.

Successful candidates will join an international and inspiring group whose work is featured in several highly-cited papers (in top quality peer-reviewed journals) with established collaborations in Australia (Institute for Molecular Bioscience and the South Australian Health and Medical Research Institute) and the USA (Center for Clinical Pharmacology, WUSTL).

Applicants should submit ONE pdf file, including a full CV, the names of at least 2 referees and a very brief (1/2 page) motivation letter; pre-interviews will be by video call. Strong skills in written and spoken English are mandatory. Applicants preferably have prior experience with receptor pharmacology and/or cell culture.