MRSI-VSC

At the High Field MR Centre of the Medical University of Vienna, we have developed a method for rapid whole-brain magnetic resonance spectroscopic imaging (MRSI) that can image neurochemical distributions in the human brain faster and with higher resolution than before. But in order to develop it into a standardised clinical tool, we still need to conduct more research and testing. MRSI-VSC (MRSI validation, standardisation, and correlation) is one of the necessary steps and will translate our MRSI method to four 7 Tesla MRI scanners in the united kingdom. We will then combine it with arterial spin labelling (ASL), a technique that adds information about perfusion, develop the processing software to be better accessible, and conduct a study in volunteers to determine the variability of results between all four scanners. The proposed combination of high resolution MRSI and ASL at 7T was never attempted before. Our aim to establish a multi-centre network with a verified neurochemical/perfusion MRI protocol will allow future collaborations that explore diseases in the human brain. Gilbert Hangel of the Medical University of Vienna, the receiver of this grant, will conduct this study at the University College London with Martina Callaghan and Barbara Dymerska and at the University of Oxford with William Clarke and Thomas Okell. Özlem Ipek from the Kings College London and Chris Rodgers from the University of Cambridge will support it with additional scans at their institutions.

At the High Field MR Centre of the Medical University of Vienna, we have developed a method for rapid whole-brain magnetic resonance spectroscopic imaging (MRSI) that can image neurochemical distributions in the human brain faster and with higher resolution than before. But in order to develop it into a standardised clinical tool, we still need to conduct more research and testing. MRSI-VSC (MRSI validation, standardisation, and correlation) is one of the necessary steps and translated our MRSI method to four 7 Tesla MRI scanners in the United Kingdom. We then combined it with arterial spin labelling (ASL), a technique that adds information about perfusion, develop the processing software to be better accessible, and conducted a study in volunteers to determine the variability of results between all four scanners. Our aim to establish a multi-centre network with a verified neurochemical/perfusion MRI protocol will allow future collaborations that explore diseases in the human brain. Gilbert Hangel of the Medical University of Vienna, the receiver of this grant, has conducted this study at the University College London with Martina Callaghan and Barbara Dymerska and at the University of Oxford with William Clarke and Thomas Okell. Özlem Ipek from the King's College London and Chris Rodgers from the University of Cambridge have supported it with additional scans at their institutions.