Tumor Immunology: Master Thesis

MASTER THESIS POSITION IN TUMOR IMMUNOLOGY

HARNESSING A20 TO MODULATE IMMUNITY IN LUNG CANCER

The Moll Laboratory at the Medical University of Vienna (MUW), Center for Physiology and Pharmacology, is seeking a highly motivated Master student candidate to join our team.

Our group focuses on tumor stroma interactions with the overarching goal of identifying novel immunotherapeutic strategies for lung cancer patients. We make use of advanced mouse models, single-cell technologies, and bioinformatics to uncover immune mechanisms that can be translated into future therapies. You find more information here: https://inflame.jimdosite.com/

Project background

Inflammation is a key driver of lung tumorigenesis. Our lab has recently uncovered that partial loss of the anti-inflammatory regulator A20 (TNFAIP3) in mice reshapes the tumor immune microenvironment, leading to altered T-cell infiltration and activation, and to the formation of tertiary lymphoid structures. We are currently investigating how these immune changes influence tumor progression and how A20 downregulation can be harnessed for immunotherapy.

This Master project will support our work by analyzing T-cell responses in vitro and assisting with ongoing mouse experiments, providing hands-on experience in tumor immunology.

Your tasks

• Isolation and in vitro stimulation/assays of T cells from mouse tissues

• Flow cytometry–based immunophenotyping and functional readouts of T-cell activation

• Assistance with mouse handling and in vivo experiments (e.g., tumor models, immune cell depletion)

• Basic molecular biology techniques to support immune analyses

• Data documentation, interpretation, and presentation within the lab team

What we offer

• A dynamic, international, and interdisciplinary research environment with expertise in tumor immunology

• Mentorship and close supervision by experienced PhD students and PIs

• Opportunities to participate in lab meetings and journal clubs

• Engagement in a collaborative team

• A stipend for the 12 month of the Master’s thesis

What we expect

• Bachelor’s degree (or equivalent) in life sciences, molecular biology, immunology, biotechnology, or related fields

• Strong interest in tumor immunology and T-cell biology

• Experience or strong interest in molecular and cellular biology techniques; mouse handling is an advantage

• Reliable, responsible, and calm approach to work

• Good communication skills and a strong willingness to learn

• Motivation, creativity, and ability to work effectively in a collaborative research environment

How to apply

Please send your CV, motivation letter, and contact details of your Bachelor or Internship supervisor to: herwig.moll(at)meduniwien.ac.at

The Medical University of Vienna is committed to diversity and equal opportunity.