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RNA@core: “Molecular mechanisms in RNA biology”

RNA@core: “Molecular mechanisms in RNA biology”

Javier Martinez Fernandez (ORCID: 0000-0001-9152-7323)
  • Grant DOI 10.55776/DOC177
  • Funding program doc.funds
  • Status ongoing
  • Start July 1, 2023
  • End June 30, 2027
  • Funding amount € 2,059,173
  • Project website

Disciplines

Biology (100%)

Keywords

    Structural Biology, Science Communication, RNA biology, Industry, Biochemistry, New Technologies

Abstract

RNA@core is a new Doctoral School funded by FWF that focuses on emerging biological and biochemical aspects of RNA molecules, multifunctional players in a living cell. RNA@core builds on a 12-year-long RNA Biology Doctoral School and aims to educate candidate PhD students recruited through the International PhD programs at the Vienna BioCenter and the Medical University of Vienna. Ground-breaking technologies in molecular biology and genetics have recently enabled great mechanistic discoveries and revolutionary therapies with RNA. To maintain this progress, it is imperative to educate the RNA biologists of tomorrow. Therefore, we have created RNA@core to fully equip PhD candidates at theoretical, practical, and communicational levels; we aim to educate PhD candidates to think critically and independently, design experiments and manage their own projects. RNA@core brings together twelve research groups, led by Junior and Senior scientists, to translate excellent research in RNA biochemistry and biology into a cutting-edge PhD training and create a dynamic and interdisciplinary network for the benefit of the students. The curriculum of RNA@core introduces key innovations such as short lab exchanges and professional coaching to learn to present projects conceptually as chalk talks and to deliver classical, slide-based presentations to an international scientific audience. RNA@core will also offer an advanced theoretical course in RNA molecular biology, a structural biology workshop focusing on enzymology in disease, and a series of short workshops dedicated to critical technologies for RNA research. To gain insights into alternatives to academic career paths, RNA@core will provide candidate PhD students with the possibility to enjoy short internships in three RNA-focused companies at the Vienna BioCenter. This initiative will allow PhD candidates to make more informed decisions for their future careers in Academia, Industry, or alternative directions. In summary, the Faculty of RNA@core expects to create a vibrant PhD training program where our students will acquire robust and interdisciplinary knowledge in RNA biology but also in transferable communication skills to tackle any challenge that may arise in their careers.

Consortium
  • Boris Görke, Universität Wien
    consortium member (01.07.2023 -)
  • Clemens Plaschka, Institut für Molekulare Pathologie - IMP
    consortium member (01.07.2023 -)
  • Elisa Vilardo, Medizinische Universität Wien
    consortium member (01.07.2023 -)
  • Gülsün Elif Karagöz, Medizinische Universität Wien
    consortium member (01.07.2023 -)
  • Isabella Moll, Universität Wien
    consortium member (01.07.2023 -)
  • Javier Martinez Fernandez, Medizinische Universität Wien
    consortium member (01.07.2023 -)
  • Julius Brennecke, IMBA – Institut für Molekulare Biotechnologie GmbH
    consortium member (01.07.2023 -)
  • Matthias R. Schaefer, Medizinische Universität Wien
    consortium member (01.07.2023 -)
  • Sebastian Falk, Universität Wien
    consortium member (01.07.2023 -)
  • Stefan L. Ameres, IMBA – Institut für Molekulare Biotechnologie GmbH
    consortium member (01.07.2023 -)
Research institution(s)
  • Medizinische Universität Wien

Research Output

  • 13 Citations
  • 8 Publications
Publications
  • 2025
    Title Collective homeostasis of condensation-prone proteins via their mRNAs
    DOI 10.1038/s41586-025-09568-w
    Type Journal Article
    Author Faraway R
    Journal Nature
    Pages 798-808
    Link Publication
  • 2025
    Title Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance
    DOI 10.1101/2025.09.09.675111
    Type Preprint
    Author Shang R
    Pages 2025.09.09.675111
    Link Publication
  • 2025
    Title Sugar caps protect mRNAs from decay
    DOI 10.1073/pnas.2527312122
    Type Journal Article
    Author Forbes R
    Journal Proceedings of the National Academy of Sciences
    Link Publication
  • 2025
    Title Hierarchical assembly and functional resilience of the mammalian RNA exosome
    DOI 10.1101/2025.03.14.643291
    Type Preprint
    Author Navalayeu T
    Pages 2025.03.14.643291
    Link Publication
  • 2025
    Title Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition
    DOI 10.1016/j.bpj.2025.08.001
    Type Journal Article
    Author Gaurav K
    Journal Biophysical Journal
    Pages 3987-4004
    Link Publication
  • 2024
    Title MUT-7 exoribonuclease activity and localization are mediated by an ancient domain
    DOI 10.1093/nar/gkae610
    Type Journal Article
    Author Busetto V
    Journal Nucleic Acids Research
    Pages 9076-9091
    Link Publication
  • 2023
    Title MUT-7 exoribonuclease activity and localisation are mediated by an ancient domain
    DOI 10.1101/2023.12.20.572533
    Type Preprint
    Author Busetto V
    Pages 2023.12.20.572533
    Link Publication
  • 2024
    Title Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition
    DOI 10.1101/2024.04.13.589337
    Type Preprint
    Author Gaurav K
    Pages 2024.04.13.589337
    Link Publication

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