RNA@core: “Molecular mechanisms in RNA biology”
Disciplines
Biology (100%)
Keywords
- Structural Biology,
- Science Communication,
- RNA biology,
- Industry,
- Biochemistry,
- New Technologies
RNA@core is a new Doctoral School funded by FWF that focuses on emerging biological and biochemical aspects of RNA molecules, multifunctional players in a living cell. RNA@core builds on a 12-year-long RNA Biology Doctoral School and aims to educate candidate PhD students recruited through the International PhD programs at the Vienna BioCenter and the Medical University of Vienna. Ground-breaking technologies in molecular biology and genetics have recently enabled great mechanistic discoveries and revolutionary therapies with RNA. To maintain this progress, it is imperative to educate the RNA biologists of tomorrow. Therefore, we have created RNA@core to fully equip PhD candidates at theoretical, practical, and communicational levels; we aim to educate PhD candidates to think critically and independently, design experiments and manage their own projects. RNA@core brings together twelve research groups, led by Junior and Senior scientists, to translate excellent research in RNA biochemistry and biology into a cutting-edge PhD training and create a dynamic and interdisciplinary network for the benefit of the students. The curriculum of RNA@core introduces key innovations such as short lab exchanges and professional coaching to learn to present projects conceptually as chalk talks and to deliver classical, slide-based presentations to an international scientific audience. RNA@core will also offer an advanced theoretical course in RNA molecular biology, a structural biology workshop focusing on enzymology in disease, and a series of short workshops dedicated to critical technologies for RNA research. To gain insights into alternatives to academic career paths, RNA@core will provide candidate PhD students with the possibility to enjoy short internships in three RNA-focused companies at the Vienna BioCenter. This initiative will allow PhD candidates to make more informed decisions for their future careers in Academia, Industry, or alternative directions. In summary, the Faculty of RNA@core expects to create a vibrant PhD training program where our students will acquire robust and interdisciplinary knowledge in RNA biology but also in transferable communication skills to tackle any challenge that may arise in their careers.
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
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consortium member (01.07.2023 -)
- Medizinische Universität Wien
Research Output
- 407 Citations
- 51 Publications
- 2 Methods & Materials
- 1 Disseminations
- 1 Fundings
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2026
Title Guardian ubiquitin E3 ligases target cancer-associated APOBEC3 deaminases for degradation to promote human genome integrity. DOI 10.1038/s41467-026-68420-5 Type Journal Article Author Budroni V Journal Nature communications -
2023
Title piRNA processing by a trimeric Schlafen-domain nuclease DOI 10.1038/s41586-023-06588-2 Type Journal Article Author Podvalnaya N Journal Nature Pages 402-409 Link Publication -
2023
Title Optimized infrared photoactivatable ribonucleoside-enhanced crosslinking and immunoprecipitation (IR-PAR-CLIP) protocol identifies novel IGF2BP3-interacting RNAs in colon cancer cells DOI 10.1261/rna.079714.123 Type Journal Article Author Anisimova A Journal RNA Pages 1818-1836 Link Publication -
2023
Title Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex DOI 10.1261/rna.079732.123 Type Journal Article Author Jaksch D Journal RNA Pages 1856-1869 Link Publication -
2023
Title Thioredoxin regulates the redox state and the activity of the human tRNA ligase complex DOI 10.1101/2023.05.26.542437 Type Preprint Author Jaksch D Pages 2023.05.26.542437 Link Publication -
2023
Title Role of the 5' end phosphorylation state for small RNA stability and target RNA regulation in bacteria DOI 10.1093/nar/gkad226 Type Journal Article Author Schilder A Journal Nucleic Acids Research Pages 5125-5143 Link Publication -
2025
Title Lessons from RatA: Why the Basics in Molecular Biology Are Still Crucial! DOI 10.3390/ijms26073100 Type Journal Article Author Fasnacht M Journal International Journal of Molecular Sciences Pages 3100 Link Publication -
2025
Title Direct cell-to-cell transmission of retrotransposons DOI 10.1101/2025.03.14.642691 Type Preprint Author Voichek M Pages 2025.03.14.642691 Link Publication -
2025
Title HaloPROTAC3 treatment activates the unfolded protein response of the endoplasmic reticulum in nonengineered mammalian cell lines DOI 10.1091/mbc.e24-08-0342 Type Journal Article Author Anisimova A Journal Molecular Biology of the Cell Link Publication -
2025
Title Mechanistic basis for PYROXD1-mediated protection of the human tRNA ligase complex against oxidative inactivation DOI 10.1038/s41594-025-01516-6 Type Journal Article Author Loeff L Journal Nature Structural & Molecular Biology Pages 1205-1212 Link Publication -
2025
Title In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-ET DOI 10.1016/j.cell.2025.02.003 Type Journal Article Author Klumpe S Journal Cell Link Publication -
2025
Title Ampicillin treatment in persister cell studies may cause non-physiological artifacts DOI 10.15698/mic2025.03.845 Type Journal Article Author Fasnacht M Journal Microbial Cell Pages 53 Link Publication -
2024
Title Author Correction: piRNA processing by a trimeric Schlafen-domain nuclease. DOI 10.1038/s41586-024-07938-4 Type Journal Article Author Bronkhorst Aw Journal Nature -
2024
Title Selfish conflict underlies RNA-mediated parent-of-origin effects DOI 10.1038/s41586-024-07155-z Type Journal Article Author Marvanova H Journal Nature -
2024
Title Genome-wide profiling of DNA repair proteins in single cells DOI 10.1038/s41467-024-54159-4 Type Journal Article Author Rullens P Journal Nature Communications -
2024
Title Multiple regulatory inputs including cell envelope stress orchestrate expression of the Escherichia coli rpoN operon. DOI 10.1111/mmi.15280 Type Journal Article Author Budja Lvp Journal Molecular microbiology Pages 11-28 -
2024
Title Mime-seq 2.0: a method to sequence microRNAs from specific mouse cell types DOI 10.1038/s44318-024-00102-8 Type Journal Article Author Mandlbauer A Journal The EMBO Journal Pages 2506-2525 Link Publication -
2024
Title Rnalib: a Python library for custom transcriptomics analyses DOI 10.1093/bioinformatics/btae751 Type Journal Article Author Popitsch N Journal Bioinformatics Link Publication -
2024
Title Splice_sim: a nucleotide conversion-enabled RNA-seq simulation and evaluation framework DOI 10.1186/s13059-024-03313-8 Type Journal Article Author Popitsch N Journal Genome Biology Pages 166 Link Publication -
2024
Title Mechanism for the initiation of spliceosome disassembly DOI 10.1038/s41586-024-07741-1 Type Journal Article Author Vorländer M Journal Nature Pages 443-450 Link Publication -
2024
Title Endoplasmic reticulum: Monitoring and maintaining protein and membrane homeostasis in the endoplasmic reticulum by the unfolded protein response DOI 10.1016/j.biocel.2024.106598 Type Journal Article Author Kettel P Journal The International Journal of Biochemistry & Cell Biology Pages 106598 Link Publication -
2024
Title MUT-7 exoribonuclease activity and localization are mediated by an ancient domain DOI 10.1093/nar/gkae610 Type Journal Article Author Busetto V Journal Nucleic Acids Research Pages 9076-9091 Link Publication -
2024
Title Proteome-scale tagging and functional screening in mammalian cells by ORFtag DOI 10.1038/s41592-024-02339-x Type Journal Article Author Nemcko F Journal Nature Methods Pages 1668-1673 Link Publication -
2024
Title Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition DOI 10.1101/2024.04.13.589337 Type Preprint Author Gaurav K Pages 2024.04.13.589337 Link Publication -
2024
Title Evaluation of 5'-End Phosphorylation for Small RNA Stability and Target Regulation In Vivo DOI 10.1007/978-1-0716-3565-0_14 Type Book Chapter Author Schilder A Publisher Springer Nature Pages 255-272 -
2024
Title Evolutionary adaptation of an HP1-protein chromodomain integrates chromatin and DNA sequence signals DOI 10.7554/elife.93194 Type Journal Article Author Baumgartner L Journal eLife Link Publication -
2023
Title SLAMseq resolves the kinetics of maternal and zygotic gene expression during early zebrafish embryogenesis DOI 10.1016/j.celrep.2023.112070 Type Journal Article Author Bhat P Journal Cell Reports Pages 112070 Link Publication -
2023
Title Shuffled ATG8 interacting motifs form an ancestral bridge between UFMylation and autophagy DOI 10.15252/embj.2022112053 Type Journal Article Author Picchianti L Journal The EMBO Journal Link Publication -
2024
Title Structural basis of human U5 snRNP late biogenesis and recycling DOI 10.1038/s41594-024-01243-4 Type Journal Article Author Riabov Bassat D Journal Nature Structural & Molecular Biology Pages 747-751 Link Publication -
2024
Title IGF2BP1 phosphorylation in the disordered linkers regulates ribonucleoprotein condensate formation and RNA metabolism DOI 10.1038/s41467-024-53400-4 Type Journal Article Author Hornegger H Journal Nature Communications Pages 9054 Link Publication -
2024
Title Disordered regions in the IRE1a ER lumenal domain mediate its stress-induced clustering DOI 10.1038/s44318-024-00207-0 Type Journal Article Author Kettel P Journal The EMBO Journal Pages 4668-4698 Link Publication -
2025
Title Sugar caps protect mRNAs from decay DOI 10.1073/pnas.2527312122 Type Journal Article Author Forbes R Journal Proceedings of the National Academy of Sciences Link Publication -
2025
Title RNA decay via the nuclear exosome is essential for Piwi-mediated transposon silencing DOI 10.64898/2025.12.16.694471 Type Preprint Author Yu C Pages 2025.12.16.694471 Link Publication -
2025
Title The unfolded protein response in progeria arteries originates from non-endothelial cell types DOI 10.26508/lsa.202503485 Type Journal Article Author Silva R Journal Life Science Alliance Link Publication -
2025
Title Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression DOI 10.1371/journal.pbio.3002984 Type Journal Article Author Chavan A Journal PLOS Biology -
2025
Title Mechanisms of Messenger RNA Packaging and Export. DOI 10.1146/annurev-cellbio-101123-045256 Type Journal Article Author Faraway R Journal Annual review of cell and developmental biology Pages 479-504 -
2025
Title An ATP-gated molecular switch orchestrates human mRNA export DOI 10.1038/s41586-025-09832-z Type Journal Article Author Hohmann U Journal Nature Pages 1042-1050 Link Publication -
2025
Title Hierarchical assembly and functional resilience of the mammalian RNA exosome DOI 10.1101/2025.03.14.643291 Type Preprint Author Navalayeu T Pages 2025.03.14.643291 Link Publication -
2025
Title Co-evolving infectivity and expression patterns drive the diversification of endogenous retroviruses DOI 10.1038/s44318-025-00471-8 Type Journal Article Author Senti K Journal The EMBO Journal Pages 1889-1908 Link Publication -
2025
Title ERH regulates type II interferon immune signaling through post-transcriptional regulation of JAK2 mRNA DOI 10.1093/nar/gkaf545 Type Journal Article Author Soderholm A Journal Nucleic Acids Research Link Publication -
2025
Title Separable roles for Microprocessor and its cofactors ERH and SAFB1/2 during microRNA cluster assistance DOI 10.1101/2025.09.09.675111 Type Preprint Author Shang R Pages 2025.09.09.675111 Link Publication -
2025
Title Collective homeostasis of condensation-prone proteins via their mRNAs DOI 10.1038/s41586-025-09568-w Type Journal Article Author Faraway R Journal Nature Pages 798-808 Link Publication -
2025
Title Multi-scale simulations of MUT-16 scaffold protein phase separation and client recognition DOI 10.1016/j.bpj.2025.08.001 Type Journal Article Author Gaurav K Journal Biophysical Journal Pages 3987-4004 Link Publication -
2025
Title Target RNA recognition drives PIWI complex assembly for transposon silencing DOI 10.1016/j.molcel.2025.08.007 Type Journal Article Author Portell-Montserrat J Journal Molecular Cell -
2023
Title Epigenetic Manipulation of Transposable and Repetitive Elements. DOI 10.1007/978-1-0716-2883-6_16 Type Journal Article Author Jachowicz Jw Journal Methods in molecular biology (Clifton, N.J.) Pages 355-368 -
2023
Title ZFP462 safeguards neural lineage specification by targeting G9A/GLP-mediated heterochromatin to silence enhancers. DOI 10.1038/s41556-022-01051-2 Type Journal Article Author Stecher K Journal Nature cell biology Pages 42-55 -
2023
Title mRNA recognition and packaging by the human transcription-export complex. DOI 10.1038/s41586-023-05904-0 Type Journal Article Author Pacheco-Fiallos B Journal Nature Pages 828-835 -
2023
Title A fine balancing act: how epitranscriptome regulates dosage compensation in mammals. DOI 10.1038/s41594-023-01055-y Type Journal Article Author Jachowicz Jw Journal Nature structural & molecular biology Pages 1057-1059 -
2023
Title MUT-7 exoribonuclease activity and localisation are mediated by an ancient domain DOI 10.1101/2023.12.20.572533 Type Preprint Author Busetto V Pages 2023.12.20.572533 Link Publication -
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Title See above Type PhD Thesis Author All Doctoral Theses Are Ongoing; None Has Been Finished. We Report This Here Because We Do Not Find A Proper Field To Indicate This. -
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DOI 10.2210/pdb8q7w/pdb Type Other
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2024
Link
Title ORFtag DOI 10.1038/s41592-024-02339-x Type Technology assay or reagent Public Access Link Link -
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Title HA-tagged RBPs mESC lines Type Cell line Public Access
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2024
Title "Dark genome and beginning of life" at the IMBA Family Day Type Participation in an open day or visit at my research institution
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2024
Title Determinants of mRNA Lifetime and Translation Efficiency Type Research grant (including intramural programme) Start of Funding 2024 Funder Vienna Science and Technology Fund