The role of APRIL in myocardial infarction

The role of APRIL in myocardial infarction

Dimitrios Tsiantoulas (ORCID: 0000-0002-7743-3192)

Disciplines

Clinical Medicine (50%); Medical-Theoretical Sciences, Pharmacy (50%)

Keywords

    Myocardial Infarction, Lymphocytes

Abstract

Dimitrios Tsiantoulas an immunologist from the Department of Laboratory Medicine of the Medical University of Vienna studies the impact of the cytokine A Proliferation Inducing Ligand (APRIL) in heart attacks. A heart attack (also termed as myocardial infarction; MI) occurs when an artery that supplies blood to the heart is blocked, which in most of the cases is caused by complications of atherosclerotic coronary artery disease, and thereby leads to myocardial cell necrosis. The immune system response to myocardial injury is a major determinant of post-MI wound healing. However, the role of APRIL in the post-MI inflammatory process is not known. These studies aim to dissect the role of APRIL in heart attacks and thereby identify novel precise immunotherapy strategies for the management of this catastrophic clinical complication.
Research institution(s)
Project participants
International project participants

Research Output

  • 30 Citations
  • 3 Publications
  • 1 Scientific Awards
Publications
  • 2023
    Title The heterogeneous cellular landscape of atherosclerosis: Implications for future research and therapies. A collaborative review from the EAS young fellows
    DOI 10.1016/j.atherosclerosis.2023.03.021
    Type Journal Article
    Author Bonacina F
    Journal Atherosclerosis
    Pages 48-56
    Link Publication
  • 2024
    Title Targeting the adaptive immune continuum in atherosclerosis and post-MI injury
    DOI 10.1016/j.atherosclerosis.2024.118616
    Type Journal Article
    Author Juhasz V
    Journal Atherosclerosis
    Pages 118616
    Link Publication
  • 2022
    Title The Spectrum of B Cell Functions in Atherosclerotic Cardiovascular Disease
    DOI 10.3389/fcvm.2022.864602
    Type Journal Article
    Author Smeets D
    Journal Frontiers in Cardiovascular Medicine
    Pages 864602
    Link Publication
Scientific Awards
  • 2023
    Title Invited speaker at the Gordon Research Conference for Atherosclerosis 2023
    Type Personally asked as a key note speaker to a conference
    Level of Recognition Continental/International