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Inflammation and Immunity

Inflammation and Immunity

Maria Sibilia (ORCID: 0000-0001-6129-5613)
  • Grant DOI 10.55776/W1212
  • Funding program Doctoral Programs
  • Status ended
  • Start July 1, 2007
  • End December 31, 2021
  • Funding amount € 7,546,644

Disciplines

Biology (25%); Clinical Medicine (40%); Medical-Theoretical Sciences, Pharmacy (35%)

Keywords

    Immunity, Inflammation, Infectiology, Transplantation, Vaccinology, Allergy

Abstract

The generation of a functional immune system is a complex process that requires multiple control mechanisms to ensure immunity against life-threatening infectious diseases and cancer and non-responsiveness or tolerance to innocuous self-antigens thereby preventing the development of autoimmunity, allergy and other inflammatory diseases. This ensures the integrity of the mammalian organism. Research in the area of Inflammation and Immunity is therefore a worldwide medical need since it will provide new insights into pathogenesis and, thus, form the basis for new therapeutic strategies for diseases such as allergy, psoriasis, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, diabetes mellitus and organ rejection. The proposed "Inflammation and Immunity" (IAI) Doctoral Program integrates basic, applied and clinical sciences to provide comprehensive and thorough up-to-date research training in these important fields aiming at facilitating interdisciplinary and translational research. Most of the groups are part of two recently established Special Research Programs (SFB- F18: "Molecular and immunological strategies for prevention, diagnosis and treatment of type I allergies"; SFB- F23: "Mechanisms of establishment and maintenance of immunological tolerance") and are associated to the two Medical University of Vienna (MUW) graduate courses "Immunology" and "Cellular and Molecular Elements of the Skin". It is the goal of the IAI Doctoral Program to provide an unifying educational excellence platform for all these existing programs (1) to establish an international PhD Program at the Medical University of Vienna; (2) to attract highly qualified graduate students selected among applicants from all over the world; (3) to offer them the opportunity to work on high profile scientific projects at the forefront of modern biology in 13 research groups with excellent scientific competence; (4) to provide them with a creative and excellent environment for research and educational training in modern biology; (5) to prepare them for a successful scientific career in basic and/or applied research. The strong cluster of researchers working in the field of IAI at the MUW provides the infrastructure, the scientific critical mass and the excellent and stimulating research and training environment to ensure the success of this new Doctoral Program. A long term goal of our endeavor is to apply the same competitive selection criteria for the recruitment of graduate students funded by other external sources. This will further strengthen the formation of a dynamically growing center of excellence in European Research in the field of IAI.

Consortium
  • Barbara Bohle, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Maria Sibilia, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Michael H. Trauner, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Robert Eferl, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Rudolf Valenta, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Thomas Wekerle, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2016)
  • Veronika Sexl, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
  • Wilfried Ellmeier, Medizinische Universität Wien
    consortium member (01.07.2007 - 31.12.2021)
Research institution(s)
  • Veterinärmedizinische Universität Wien
  • Medizinische Universität Wien
  • CeMM – Forschungszentrum für Molekulare Medizin GmbH
Project participants
  • Andreas Bergthaler, CeMM – Forschungszentrum für Molekulare Medizin GmbH , associated research partner
  • Mathias Müller, Veterinärmedizinische Universität Wien , associated research partner
  • Stephan Hann, Universität für Bodenkultur Wien , national collaboration partner
  • Christopher Gerner, Universität Wien , national collaboration partner
  • Kurt Schmidt, Universität Graz , national collaboration partner
  • Joachim Seipelt, Medizinische Universität Wien , national collaboration partner
  • Erwin F. Wagner, Medizinische Universität Wien , national collaboration partner
  • Christian Seiser, Medizinische Universität Wien , national collaboration partner
  • Giulio Gino Maria Superti-Furga, CeMM – Forschungszentrum für Molekulare Medizin GmbH , national collaboration partner
International project participants
  • Rama Khokha, University of Toronto - Canada
  • Stipan Jonjic, University Rijeka - Croatia
  • Lars K. Poulsen, National University Hospital Copenhagen - Denmark
  • Jens Gerwien, Novo Nordisk A/S - Denmark
  • Stephane Bressanelli, CNRS - Gif sur Yvette - France
  • Jean Lepault, Centre National de la Recherche Scientifique - France
  • Felix Rey, Institut Pasteur - France
  • Adelheid Maria Cerwenka, Universitätsmedizin Mannheim - Germany
  • Lukas Flatz, Universitätsklinikum Tübingen - Germany
  • Peter Hasselblatt, Universitätsklinikum Freiburg - Germany
  • Karl Sebastian Lang, Universitätsklinikum Essen - Germany
  • Admar Verschoor, Universität Lübeck - Germany
  • Michael Roggendorf, Universität Duisburg-Essen - Germany
  • Jens T. Siveke, Universität Duisburg-Essen - Germany
  • Ulrich Kalinke, TWINCORE Zentrum für Experimentelle und Klinische Infektionsforschung - Germany
  • Susetta Finotto, Universitätsklinikum Erlangen - Germany
  • Stefan Vieths, Paul-Ehrlich-Institut - Germany
  • Andreas Diefenbach, Albert-Ludwigs-Universität Freiburg - Germany
  • Ahmed Hegazy, Charité - Campus Benjamin Franklin - Germany
  • Max Löhning, Charité - Universitätsmedizin Berlin - Germany
  • Stephan Scheurer, Paul-Ehrlich-Institut - Germany
  • Michael Gekle, Martin-Luther-Universität Halle - Germany
  • Thomas Wunderlich, Max-Planck-Gesellschaft - Germany
  • Philipp A. Lang, Heinrich Heine Universität Düsseldorf - Germany
  • Steffen Jung, Weizmann Institute of Science - Israel
  • Valeria Poli, University of Turin - Italy
  • Ichiro Taniuchi, RIKEN Center for Integrative Medical Sciences (IMS) - Japan
  • Hiroyuki Nawa, Niigata University - Japan
  • Marije Koenders, University Medical Center Nijmegen - Netherlands
  • Wim Van Den Berg, Radboud University Medical Centre - Netherlands
  • Roy Gerth Van Wijk, Erasmus University Medical Center - Netherlands
  • Rudolf W. Hendriks, Erasmus University Medical Center Rotterdam Universitair Medisch Centrum Rotterdam - Netherlands
  • Maria Manuel Mota, University of Lisbon - Portugal
  • Isabel Fabregat, Bellvitge Biomedical Research Institute (IDIBELL) - Spain
  • Mariano Barbacid, Centro National de Investigaciones Oncologicas - Spain
  • Marcos Malumbres, Vall d´Hebron Institute of Oncology - Spain
  • C.I. Edvard Smith, Karolinska Institutet - Sweden
  • Thomas Jung, Novartis Exploratory Development - Switzerland
  • Doron Merkler, University of Geneva - Switzerland
  • Daniel Pinschewer, Universität Basel - Switzerland
  • Urs Karrer, Kantonspital Winterthur - Switzerland
  • Patrick Matthias, Friedrich Miescher Institute for Biomedical Research - Switzerland
  • Burkhard Ludewig, HOCH Health Ostschweiz - Switzerland
  • Takeshi Egawa, Washington University in St. Louis - USA
  • Marco Colonna, Washington University School of Medicine - USA
  • Andrew C. Larner, Virginia Commonwealth University - USA
  • Greg Lemke, The Salk Institut - USA
  • James Glenn Krueger, The Rockefeller University - USA
  • Kay-Uwe Wagner, University of Nebraska Medical Center - USA
  • David Symer, Ohio State University - USA
  • Jane A. Skok, New York University Medical Center - USA
  • Lothar Hennighausen, National Institutes of Health - USA
  • Hilde Cheroutre, La Jolla Institute for Allergy and Immunology - USA
  • Fritz H. Bach, Harvard University - USA
  • Alan A. Aderem, Seattle Biomedical Research Institute - USA
  • Peter Ghazal, University of Edinburgh Medical School
  • Francesco Colucci, The Babraham Institute
  • Dies Meijer, University of Edinburgh
  • Elopy Sibanda, University of Zimbabwe - Zimbabwe

Research Output

  • 8914 Citations
  • 195 Publications
Publications
  • 2025
    Title Systemic IFN-I combined with topical TLR7/8 agonists promotes distant tumor suppression by c-Jun-dependent IL-12 expression in dendritic cells
    DOI 10.1038/s43018-024-00889-9
    Type Journal Article
    Author Sanlorenzo M
    Journal Nature Cancer
    Pages 175-193
    Link Publication
  • 2025
    Title 24-Nor-ursodeoxycholic acid improves intestinal inflammation by targeting TH17 pathogenicity and transdifferentiation
    DOI 10.1136/gutjnl-2024-333297
    Type Journal Article
    Author Zhu C
    Journal Gut
    Pages 1079-1093
    Link Publication
  • 2025
    Title Vitamin K supports TGF-ß1 depended in vitro human Langerhans cell differentiation and function via Axl
    DOI 10.3389/fimmu.2025.1509228
    Type Journal Article
    Author Bauer T
    Journal Frontiers in Immunology
    Pages 1509228
    Link Publication
  • 2025
    Title HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
    DOI 10.1084/jem.20240829
    Type Journal Article
    Author Rica R
    Journal Journal of Experimental Medicine
    Link Publication
  • 2024
    Title JAK-STAT1 as therapeutic target for EGFR deficiency-associated inflammation and scarring alopecia
    DOI 10.1038/s44321-024-00166-3
    Type Journal Article
    Author Strobl K
    Journal EMBO Molecular Medicine
    Pages 3142-3168
    Link Publication
  • 2024
    Title Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
    DOI 10.7554/elife.78738
    Type Journal Article
    Author Stolz V
    Journal eLife
    Link Publication
  • 2024
    Title Cyclin C promotes development and progression of B-cell acute lymphoblastic leukemia by counteracting p53-mediated stress responses
    DOI 10.3324/haematol.2024.285701
    Type Journal Article
    Author Trifinopoulos J
    Journal Haematologica
    Pages 877-892
    Link Publication
  • 2021
    Title The AP-1 transcription factors c-Jun and JunB are essential for CD8a conventional dendritic cell identity
    DOI 10.1038/s41418-021-00765-4
    Type Journal Article
    Author Novoszel P
    Journal Cell Death & Differentiation
    Pages 2404-2420
    Link Publication
  • 2021
    Title Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells
    DOI 10.3389/fimmu.2021.535039
    Type Journal Article
    Author Gülich A
    Journal Frontiers in Immunology
    Pages 535039
    Link Publication
  • 2021
    Title Psoriatic skin inflammation is promoted by c-Jun/AP-1-dependent CCL2 and IL-23 expression in dendritic cells
    DOI 10.15252/emmm.202012409
    Type Journal Article
    Author Novoszel P
    Journal EMBO Molecular Medicine
    Link Publication
  • 2021
    Title Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance
    DOI 10.1038/s41419-021-04279-2
    Type Journal Article
    Author Knab V
    Journal Cell Death & Disease
    Pages 991
    Link Publication
  • 2021
    Title ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN?-driven immunopathology
    DOI 10.1101/2021.08.09.455606
    Type Preprint
    Author Gawish R
    Pages 2021.08.09.455606
    Link Publication
  • 2022
    Title Identification of apple cultivars hypoallergenic for birch pollen-allergic individuals by a multidisciplinary in vitro and in vivo approach
    DOI 10.1002/clt2.12186
    Type Journal Article
    Author Strobl M
    Journal Clinical and Translational Allergy
    Link Publication
  • 2021
    Title Untwining Anti-Tumor and Immunosuppressive Effects of JAK Inhibitors—A Strategy for Hematological Malignancies?
    DOI 10.3390/cancers13112611
    Type Journal Article
    Author Klein K
    Journal Cancers
    Pages 2611
    Link Publication
  • 2021
    Title Histone deacetylase 1 controls CD4+ T cell trafficking in autoinflammatory diseases
    DOI 10.1016/j.jaut.2021.102610
    Type Journal Article
    Author Hamminger P
    Journal Journal of Autoimmunity
    Pages 102610
    Link Publication
  • 2024
    Title A lineage-specific STAT5B N642H mouse model to study NK-cell leukemia
    DOI 10.1182/blood.2023022655
    Type Journal Article
    Author Klein K
    Journal Blood
    Pages 2474-2489
    Link Publication
  • 2024
    Title HDAC1 controls the generation and maintenance of effector-like CD8+ T cells during chronic viral infection
    DOI 10.1101/2024.02.28.580886
    Type Preprint
    Author Rica R
    Pages 2024.02.28.580886
    Link Publication
  • 2024
    Title Increase in ER-mitochondria contacts and mitochondrial fusion are hallmarks of mitochondrial activation during embryogenesis
    DOI 10.1101/2024.06.11.598492
    Type Preprint
    Author Chugunova A
    Pages 2024.06.11.598492
    Link Publication
  • 2024
    Title The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
    DOI 10.1016/j.celrep.2024.114308
    Type Journal Article
    Author De Sá Fernandes C
    Journal Cell Reports
    Pages 114308
    Link Publication
  • 2022
    Title BMPR1a Is Required for the Optimal TGFß1-Dependent CD207+ Langerhans Cell Differentiation and Limits Skin Inflammation through CD11c+ Cells
    DOI 10.1016/j.jid.2022.02.014
    Type Journal Article
    Author Hochgerner M
    Journal Journal of Investigative Dermatology
    Link Publication
  • 2020
    Title NCOR1 Orchestrates Transcriptional Landscapes and Effector Functions of CD4+ T Cells
    DOI 10.3389/fimmu.2020.00579
    Type Journal Article
    Author Hainberger D
    Journal Frontiers in Immunology
    Pages 579
    Link Publication
  • 2020
    Title TYK2 in Tumor Immunosurveillance
    DOI 10.3390/cancers12010150
    Type Journal Article
    Author Karjalainen A
    Journal Cancers
    Pages 150
    Link Publication
  • 2020
    Title Histone deacetylases 1 and 2 restrain CD4+ cytotoxic T lymphocyte differentiation
    DOI 10.1172/jci.insight.133393
    Type Journal Article
    Author Preglej T
    Journal JCI Insight
    Link Publication
  • 2020
    Title Loss of NKG2D in murine NK cells leads to increased perforin production upon long-term stimulation with IL-2
    DOI 10.1002/eji.201948222
    Type Journal Article
    Author Prinz D
    Journal European Journal of Immunology
    Pages 880-890
    Link Publication
  • 2020
    Title EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
    DOI 10.1038/s41416-020-0943-2
    Type Journal Article
    Author Hippe A
    Journal British Journal of Cancer
    Pages 942-954
    Link Publication
  • 2020
    Title Histone deacetylases as targets in autoimmune and autoinflammatory diseases
    DOI 10.1016/bs.ai.2020.06.001
    Type Book Chapter
    Author Hamminger P
    Publisher Elsevier
    Pages 1-59
  • 2019
    Title The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation
    DOI 10.1007/s00018-019-03119-z
    Type Journal Article
    Author Orola M
    Journal Cellular and Molecular Life Sciences
    Pages 4391-4404
    Link Publication
  • 2019
    Title Deutsche Übersetzung und Validierung des VMIQ-2 zur Erfassung der Lebhaftigkeit von Handlungsvorstellungen
    DOI 10.1026/1612-5010/a000273
    Type Journal Article
    Author Dahm S
    Journal Zeitschrift fur sportpsychologie
    Pages 151-158
    Link Publication
  • 2019
    Title Myeloid Cells Restrict MCMV and Drive Stress-Induced Extramedullary Hematopoiesis through STAT1
    DOI 10.1016/j.celrep.2019.02.017
    Type Journal Article
    Author Gawish R
    Journal Cell Reports
    Link Publication
  • 2021
    Title The energy sensor AMPK orchestrates metabolic and translational adaptation in expanding T helper cells
    DOI 10.1096/fj.202001763rr
    Type Journal Article
    Author Mayer K
    Journal The FASEB Journal
    Link Publication
  • 2021
    Title SARS-CoV-2 mutations in MHC-I–restricted epitopes evade CD8+ T cell responses
    DOI 10.1126/sciimmunol.abg6461
    Type Journal Article
    Author Agerer B
    Journal Science Immunology
    Link Publication
  • 2021
    Title 24-Nor-Ursodeoxycholic acid reshapes immunometabolism in CD8+ T cells and alleviates hepatic inflammation
    DOI 10.1101/2021.01.09.426037
    Type Preprint
    Author Zhu C
    Pages 2021.01.09.426037
    Link Publication
  • 2021
    Title T Cell-Intrinsic CDK6 Is Dispensable for Anti-Viral and Anti-Tumor Responses In Vivo
    DOI 10.3389/fimmu.2021.650977
    Type Journal Article
    Author Klein K
    Journal Frontiers in Immunology
    Pages 650977
    Link Publication
  • 2021
    Title Characterization of CD8 T Cell-Mediated Mutations in the Immunodominant Epitope GP33-41 of Lymphocytic Choriomeningitis Virus
    DOI 10.3389/fimmu.2021.638485
    Type Journal Article
    Author Smyth M
    Journal Frontiers in Immunology
    Pages 638485
    Link Publication
  • 2025
    Title TYK2 Promotes Immunosurveillance of Colorectal Cancer Liver Metastasis.
    DOI 10.1158/0008-5472.can-24-4224
    Type Journal Article
    Author Mödl B
    Journal Cancer research
  • 2025
    Title EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer
    DOI 10.1038/s44321-025-00240-4
    Type Journal Article
    Author Krauß D
    Journal EMBO Molecular Medicine
    Pages 1355-1392
    Link Publication
  • 2025
    Title Multi-omics and functional characterization of the tumor-killing capacity of Imiquimod-activated plasmacytoid dendritic cells
    DOI 10.1016/j.isci.2025.112670
    Type Journal Article
    Author Gastaldi T
    Journal iScience
    Pages 112670
    Link Publication
  • 2020
    Title STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity
    DOI 10.3389/fimmu.2020.02189
    Type Journal Article
    Author Meissl K
    Journal Frontiers in Immunology
    Pages 2189
    Link Publication
  • 2019
    Title The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease
    DOI 10.1016/j.ccell.2018.11.018
    Type Journal Article
    Author Kosack L
    Journal Cancer Cell
    Link Publication
  • 2019
    Title EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner
    DOI 10.1016/j.isci.2019.04.018
    Type Journal Article
    Author Amberg N
    Journal iScience
    Pages 243-256
    Link Publication
  • 2019
    Title Oral Presentations: Thursday, 11 April 2019
    DOI 10.1016/s0168-8278(19)30199-0
    Type Journal Article
    Journal Journal of Hepatology
    Link Publication
  • 2019
    Title Poster Presentations: Posters Thursday, 11 April 2019
    DOI 10.1016/s0168-8278(19)30203-x
    Type Journal Article
    Journal Journal of Hepatology
    Link Publication
  • 2019
    Title STAT5BN642H drives transformation of NKT cells: a novel mouse model for CD56+ T-LGL leukemia
    DOI 10.1038/s41375-019-0471-3
    Type Journal Article
    Author Klein K
    Journal Leukemia
    Pages 2336-2340
    Link Publication
  • 2019
    Title BMP7 aberrantly induced in the psoriatic epidermis instructs inflammation-associated Langerhans cells
    DOI 10.1016/j.jaci.2019.12.011
    Type Journal Article
    Author Borek I
    Journal Journal of Allergy and Clinical Immunology
    Link Publication
  • 2022
    Title 24-Nor-ursodeoxycholic acid counteracts TH17/Treg imbalance and ameliorates intestinal inflammation by restricting glutaminolysis in differentiating TH17 cells
    DOI 10.1101/2022.02.10.479975
    Type Preprint
    Author Zhu C
    Pages 2022.02.10.479975
    Link Publication
  • 2022
    Title Fos regulates macrophage infiltration against surrounding tissue resistance by a cortical actin-based mechanism in Drosophila
    DOI 10.1371/journal.pbio.3001494
    Type Journal Article
    Author Belyaeva V
    Journal PLoS Biology
    Link Publication
  • 2022
    Title ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFN?-driven immunopathology
    DOI 10.7554/elife.74623
    Type Journal Article
    Author Gawish R
    Journal eLife
    Link Publication
  • 2022
    Title Oncogenic TYK2P760L kinase is effectively targeted by combinatorial TYK2, mTOR and CDK4/6 kinase blockade
    DOI 10.3324/haematol.2021.279848
    Type Journal Article
    Author Woess K
    Journal Haematologica
    Pages 993-1005
    Link Publication
  • 2022
    Title Lipid Metabolism Interplay in CRC—An Update
    DOI 10.3390/metabo12030213
    Type Journal Article
    Author Krauß D
    Journal Metabolites
    Pages 213
    Link Publication
  • 2022
    Title Emergence of SARS-CoV-2 Alpha lineage and its correlation with quantitative wastewater-based epidemiology data
    DOI 10.1016/j.watres.2022.118257
    Type Journal Article
    Author Radu E
    Journal Water Research
    Pages 118257
    Link Publication
  • 2022
    Title Nuclear receptor corepressor 1 controls regulatory T cell subset differentiation and effector function
    DOI 10.1101/2022.03.24.485609
    Type Preprint
    Author Stolz V
    Pages 2022.03.24.485609
    Link Publication
  • 2022
    Title Stress signaling boosts interferon-induced gene transcription in macrophages
    DOI 10.1126/scisignal.abq5389
    Type Journal Article
    Author Boccuni L
    Journal Science Signaling
  • 2023
    Title FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice
    DOI 10.15252/emmm.202216758
    Type Journal Article
    Author Malik B
    Journal EMBO Molecular Medicine
    Link Publication
  • 2023
    Title A lineage-specific STAT5BN642H mouse model to study NK-cell leukemia
    DOI 10.1101/2023.10.04.560502
    Type Preprint
    Author Klein K
    Pages 2023.10.04.560502
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    Title The soluble cytoplasmic tail of CD45 regulates T-cell activation via TLR4 signaling
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    Title Hair eruption initiates and commensal skin microbiota aggravate adverse events of anti-EGFR therapy
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    Title The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3+ Regulatory T Cells
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    Title TYK2: An Upstream Kinase of STATs in Cancer
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    Title Iron Deprivation in Human T Cells Induces Nonproliferating Accessory Helper Cells
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    Title miR-181a Modulation of ERK-MAPK Signaling Sustains DC-SIGN Expression and Limits Activation of Monocyte-Derived Dendritic Cells
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    Title IgE-blocking antibodies following SLIT with recombinant Mal d 1 accord with improved apple allergy
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  • 2020
    Title Epidermal autonomous VEGFA/Flt1/Nrp1 functions mediate psoriasis-like disease
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    Title Repression of the B cell identity factor Pax5 is not required for plasma cell development
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    Title A systematic genetic interaction map of human solute carriers assigns a role to SLC25A51/MCART1 in mitochondrial NAD uptake
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    Title Dithranol targets keratinocytes, their crosstalk with neutrophils and inhibits the IL-36 inflammatory loop in psoriasis
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  • 2020
    Title Distinct roles for major and minor antigen barriers in chimerism-based tolerance under irradiation-free conditions
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  • 2020
    Title Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import
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    Journal Nature Communications
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    Title Bone morphogenetic protein signaling regulates skin inflammation via modulating dendritic cell function
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  • 2009
    Title The protein tyrosine kinase Tec regulates mast cell function
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    Title Skin Inflammation Is Not Sufficient to Break Tolerance Induced against a Novel Antigen
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  • 2009
    Title Epidermal Growth Factor Receptor Signaling Synergizes with Hedgehog/GLI in Oncogenic Transformation via Activation of the MEK/ERK/JUN Pathway
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    Title The Role of Tec Family Kinases in Mononuclear Phagocytes
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  • 2023
    Title Scarring hair follicle destruction is driven by the collapse of EGFR-protected JAK-STAT1-sensitive stem cell immune privilege
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    Title Engagement of distinct epitopes on CD43 induces different co-stimulatory pathways in human T cells
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    Title Minor Antigen Disparities Impede Induction of Long Lasting Chimerism and Tolerance through Bone Marrow Transplantation with Costimulation Blockade
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  • 2016
    Title Oncolytic influenza A virus expressing interleukin-15 decreases tumor growth in vivo
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    Title Cell Therapy for Prophylactic Tolerance in Immunoglobulin E-mediated Allergy
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    Title Characterization of the T-cell response to Dau c 1, the Bet v 1-homolog in carrot
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    Title Allergologie
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    Title Effects of Depilation Methods on Imiquimod-Induced Skin Inflammation in Mice
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    Title The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state
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    Title Incomplete clonal deletion as prerequisite for tissue-specific minor antigen tolerization
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  • 2016
    Title Anti-OX40L alone or in combination with anti-CD40L and CTLA4Ig does not inhibit the humoral and cellular response to a major grass pollen allergen
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  • 2016
    Title Effects of Imiquimod on Hair Follicle Stem Cells and Hair Cycle Progression
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  • 2016
    Title Monitoring Allergen Immunotherapy Effects by Microarray
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    Title STAT5 Is a Key Regulator in NK Cells and Acts as a Molecular Switch from Tumor Surveillance to Tumor Promotion
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  • 2018
    Title ADAM17 is required for EGF-R–induced intestinal tumors via IL-6 trans-signaling
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    Title Neutrophils promote T-cell–mediated inflammation in allergy
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    Title NK Cell–Specific CDK8 Deletion Enhances Antitumor Responses
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  • 2018
    Title RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure
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  • 2018
    Title The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment
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  • 2018
    Title EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
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  • 2018
    Title STAT1 is a sex-specific tumor suppressor in colitis-associated colorectal cancer
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  • 2017
    Title EWS-FLI1 perturbs MRTFB/YAP-1/TEAD target gene regulation inhibiting cytoskeletal autoregulatory feedback in Ewing sarcoma
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    Title STATs in NK-Cells: The Good, the Bad, and the Ugly
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  • 2018
    Title NCOR1—a new player on the field of T cell development
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    Title Impaired neural stem cell expansion and hypersensitivity to epileptic seizures in mice lacking the EGFR in the brain
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  • 2018
    Title EGFR is required for FOS-dependent bone tumor development via RSK2/CREB signaling
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  • 2018
    Title PS-005 Immunomodulatory mechanisms of the novel therapeutic bile acid 24-nor-ursodeoxycholic acid
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    Title Blockade of adhesion molecule lymphocyte function–associated antigen-1 improves long-term heart allograft survival in mixed chimeras
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  • 2016
    Title IgE and allergen-specific immunotherapy-induced IgG4 recognize similar epitopes of Bet v 1, the major allergen of birch pollen
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    Title The Immunosuppressive Effect of CTLA4 Immunoglobulin Is Dependent on Regulatory T Cells at Low But Not High Doses
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  • 2015
    Title Comparison of the Specificities of IgG, IgG-Subclass, IgA and IgM Reactivities in African and European HIV-Infected Individuals with an HIV-1 Clade C Proteome-Based Array
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    Title EGFR Signaling in Liver Diseases
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    Title Usefulness of recombinant ?-gliadin 1 for identifying patients with celiac disease and monitoring adherence to a gluten-free diet
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  • 2015
    Title Natural clinical tolerance to peanut in African patients is caused by poor allergenic activity of peanut IgE
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  • 2015
    Title Rapamycin and CTLA4Ig Synergize to Induce Stable Mixed Chimerism Without the Need for CD40 Blockade
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    Title Molecular control of CD4+ T cell lineage plasticity and integrity
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    Title CDK6—a review of the past and a glimpse into the future: from cell-cycle control to transcriptional regulation
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    Title Deletional and regulatory mechanisms coalesce to drive transplantation tolerance through mixed chimerism
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    Title Reduction in allergen-specific IgE binding as measured by microarray: A possible surrogate marker for effects of specific immunotherapy
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  • 2015
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    Title CCL7 contributes to the TNF-alpha-dependent inflammation of lesional psoriatic skin
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    Title Correlation of sensitizing capacity and T-cell recognition within the Bet v 1 family
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    Title MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development
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    Title HIV microarray for the mapping and characterization of HIV-specific antibody responses
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    Title Murine models of transplantation tolerance through mixed chimerism: advances and roadblocks
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  • 2017
    Title Protein structure shapes immunodominance in the CD4 T cell response to yellow fever vaccination
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    Title Hepatocyte-Specific Deletion of EGFR in Mice Reduces Hepatic Abcg2 Transport Activity Measured by [11C]erlotinib and Positron Emission Tomography
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    Title Epidermal Growth Factor Receptor Expression Licenses Type-2 Helper T Cells to Function in a T Cell Receptor-Independent Fashion
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    Title A T cell-specific deletion of HDAC1 protects against experimental autoimmune encephalomyelitis
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    Title EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
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  • 2017
    Title Combining Adoptive Treg Transfer with Bone Marrow Transplantation for Transplantation Tolerance
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  • 2017
    Title The corepressor NCOR1 regulates the survival of single-positive thymocytes
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    Title Transplantation Tolerance through Hematopoietic Chimerism: Progress and Challenges for Clinical Translation
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    Title Transferrin receptor 1 is a cellular receptor for human heme-albumin
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    Title Methods to Detect MHC-Specific IgE in Mice and Men
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  • 2020
    Title SARS-CoV-2 escapes CD8 T cell surveillance via mutations in MHC-I restricted epitopes
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  • 2013
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    Title EGF Receptor Is Required for KRAS-Induced Pancreatic Tumorigenesis
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    Title Anti-LFA-1 or rapamycin overcome costimulation blockade-resistant rejection in sensitized bone marrow recipients
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    Title The Role of BTB-Zinc Finger Transcription Factors During T Cell Development and in the Regulation of T Cell-mediated Immunity
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    Title Donor CD4 T Cells Trigger Costimulation Blockade-Resistant Donor Bone Marrow Rejection Through Bystander Activation Requiring IL-6
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    Title CDK6 as a key regulator of hematopoietic and leukemic stem cell activation
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    Title Specific roles for dendritic cell subsets during initiation and progression of psoriasis
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    Title Conditional ablation of TYK2 in immunity to viral infection and tumor surveillance
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    Title HDAC1 Controls CD8+ T Cell Homeostasis and Antiviral Response
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    Title The Non-receptor Tyrosine Kinase Tec Controls Assembly and Activity of the Noncanonical Caspase-8 Inflammasome
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    Title Loss of STAT3 in murine NK cells enhances NK cell–dependent tumor surveillance
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    Title Changing Views of the Role of Langerhans Cells
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    Title Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells
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  • 2012
    Title Imiquimod clears tumors in mice independent of adaptive immunity by converting pDCs into tumor-killing effector cells
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  • 2012
    Title TRAIL+ Human Plasmacytoid Dendritic Cells Kill Tumor Cells In Vitro: Mechanisms of Imiquimod- and IFN-a–Mediated Antitumor Reactivity
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  • 2012
    Title EFIS-EJI African International Conference on Immunity (AICI)
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    Title Rhinovirus infections and immunisation induce cross-serotype reactive antibodies to VP1
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    Title Myeloid STAT3 promotes formation of colitis-associated colorectal cancer in mice
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  • 2015
    Title Human CD4+ T Helper Cell Responses after Tick-Borne Encephalitis Vaccination and Infection
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  • 2014
    Title The Impact of Nitration on the Structure and Immunogenicity of the Major Birch Pollen Allergen Bet v 1.0101
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  • 2014
    Title Human Th2 but Not Th9 Cells Release IL-31 in a STAT6/NF-?B–Dependent Way
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  • 2011
    Title Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/- (Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO output
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  • 2010
    Title miR-146a Is Differentially Expressed by Myeloid Dendritic Cell Subsets and Desensitizes Cells to TLR2-Dependent Activation
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    Journal The Journal of Immunology
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    Title Methods to Study MAP Kinase Signalling in the Central Nervous System
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    Title Conditional Deletion of Histone Deacetylase 1 in T Cells Leads to Enhanced Airway Inflammation and Increased Th2 Cytokine Production
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  • 2010
    Title Autocrine VEGF Signaling Synergizes with EGFR in Tumor Cells to Promote Epithelial Cancer Development
    DOI 10.1016/j.cell.2009.12.046
    Type Journal Article
    Author Lichtenberger B
    Journal Cell
    Pages 268-279
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  • 2014
    Title 144 STAT1 isoforms in transcriptional control – Distinct traits
    DOI 10.1016/j.cyto.2014.07.151
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    Author Parrini M
    Journal Cytokine
    Pages 62-63
  • 2013
    Title The site of allergen expression in hematopoietic cells determines the degree and quality of tolerance induced through molecular chimerism
    DOI 10.1002/eji.201243277
    Type Journal Article
    Author Baranyi U
    Journal European Journal of Immunology
    Pages 2451-2460
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  • 2013
    Title PAK-dependent STAT5 serine phosphorylation is required for BCR-ABL-induced leukemogenesis
    DOI 10.1038/leu.2013.351
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    Author Berger A
    Journal Leukemia
    Pages 629-641
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  • 2013
    Title A Kinase-Independent Function of CDK6 Links the Cell Cycle to Tumor Angiogenesis
    DOI 10.1016/j.ccr.2013.07.012
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    Author Kollmann K
    Journal Cancer Cell
    Pages 167-181
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  • 2013
    Title Identification of bone morphogenetic protein 7 (BMP7) as an instructive factor for human epidermal Langerhans cell differentiation
    DOI 10.1084/jem.20130275
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    Author Yasmin N
    Journal Journal of Experimental Medicine
    Pages 2597-2610
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  • 2013
    Title ß-Catenin Promotes the Differentiation of Epidermal Langerhans Dendritic Cells
    DOI 10.1038/jid.2012.481
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    Author Yasmin N
    Journal Journal of Investigative Dermatology
    Pages 1250-1259
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  • 2014
    Title STAT1ß Is Not Dominant Negative and Is Capable of Contributing to Gamma Interferon-Dependent Innate Immunity
    DOI 10.1128/mcb.00295-14
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    Author Semper C
    Journal Molecular and Cellular Biology
    Pages 2235-2248
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  • 2014
    Title EGFR has a tumour-promoting role in liver macrophages during hepatocellular carcinoma formation
    DOI 10.1038/ncb3031
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    Author Lanaya H
    Journal Nature Cell Biology
    Pages 972-981
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  • 2014
    Title CD4+ T cell lineage integrity is controlled by the histone deacetylases HDAC1 and HDAC2
    DOI 10.1038/ni.2864
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    Author Boucheron N
    Journal Nature Immunology
    Pages 439-448
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  • 2014
    Title Persistence of IgE-Associated Allergy and Allergen-Specific IgE despite CD4+ T Cell Loss in AIDS
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    Author Marth K
    Journal PLoS ONE
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  • 2014
    Title 24-nor-ursodeoxycholic acid ameliorates inflammatory response and liver fibrosis in a murine model of hepatic schistosomiasis
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    Author Sombetzki M
    Journal Journal of Hepatology
    Pages 871-878
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  • 2014
    Title Calcium and Calcineurin-NFAT Signaling Regulate Granulocyte-Monocyte Progenitor Cell Cycle via Flt3-L
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    Journal Stem Cells
    Pages 3232-3244
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    Title Specificities of Human CD4+ T Cell Responses to an Inactivated Flavivirus Vaccine and Infection: Correlation with Structure and Epitope Prediction
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    Title Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses?
    DOI 10.1016/j.jaci.2013.10.058
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    Journal Journal of Allergy and Clinical Immunology
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  • 2014
    Title “Overrepresentation of T17 cells in the peripheral blood of psoriatic patients is not confined to the skin-homing T cell subset”
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    Author Zhou J
    Journal Journal of Dermatological Science
    Pages 190-193
  • 2014
    Title Mouse Models of Receptor Tyrosine Kinases
    DOI 10.1007/978-1-4939-2053-2_11
    Type Book Chapter
    Author Holcmann M
    Publisher Springer Nature
    Pages 279-438
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    Title Identification of Axl as a downstream effector of TGF-ß1 during Langerhans cell differentiation and epidermal homeostasis
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  • 2012
    Title How imiquimod licenses plasmacytoid dendritic cells to kill tumors
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    Journal OncoImmunology
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    Title A food matrix reduces digestion and absorption of food allergens in vivo
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    Journal Molecular Nutrition & Food Research
    Pages 1484-1491
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    Title Tec family kinases: regulation of FceRI-mediated mast-cell activation
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    Journal The FEBS Journal
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    Title Btk is a positive regulator in the TREM-1/DAP12 signaling pathway
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    Title Immune functions of the skin
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    Journal Clinics in Dermatology
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    Title Central Nervous System Mast Cells in Peripheral Inflammatory Nociception
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    Journal Molecular Pain
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    Title Pru p 3, the nonspecific lipid transfer protein from peach, dominates the immune response to its homolog in hazelnut
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    Author Schulten V
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    Title Transcriptional control of CD4 and CD8 coreceptor expression during T cell development
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    Author Ellmeier W
    Journal Cellular and Molecular Life Sciences
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    Title The Transcription Factor MAZR Preferentially Acts as a Transcriptional Repressor in Mast Cells and Plays a Minor Role in the Regulation of Effector Functions in Response to FceRI Stimulation
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    Journal PLoS ONE
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  • 2013
    Title Epidermal EGFR Controls Cutaneous Host Defense and Prevents Inflammation
    DOI 10.1126/scitranslmed.3005886
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    Journal Science Translational Medicine
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    Title The Tyrosine Kinase Btk Regulates the Macrophage Response to Listeria monocytogenes Infection
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    Journal PLoS ONE
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    Title Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip
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    Journal Methods
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    Title A combined biochemical, biophysical and immunological approach towards the identification of celiac disease-specific wheat antigens
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    Author Srinivasan B
    Journal Amino Acids
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    Title Dissection of Antibody Specificities Induced by Yellow Fever Vaccination
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    Journal PLoS Pathogens
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  • 2013
    Title Entry of human rhinovirus 89 via ICAM-1 into HeLa epithelial cells is inhibited by actin skeleton disruption and by bafilomycin
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    Journal Archives of Virology
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    Title Divergent roles of HDAC1 and HDAC2 in the regulation of epidermal development and tumorigenesis
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    Journal The EMBO Journal
    Pages 3176-3191
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  • 2013
    Title Infliximab induces downregulation of the IL-12/IL-23 axis in 6-sulfo-LacNac (slan)+ dendritic cells and macrophages
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    Journal Journal of Allergy and Clinical Immunology
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    Title Kinetics, cross-reactivity, and specificity of Bet v 1-specific IgG4 antibodies induced by immunotherapy with birch pollen
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    Author Subbarayal B
    Journal Allergy
    Pages 1377-1386
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    Title 24-norUrsodeoxycholic Acid Is Superior to Ursodeoxycholic Acid in the Treatment of Sclerosing Cholangitis in Mdr2 (Abcb4) Knockout Mice
    DOI 10.1053/j.gastro.2005.10.018
    Type Journal Article
    Author Fickert P
    Journal Gastroenterology
    Pages 465-481
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