Targeting Neuroinflammation in Friedreich´s Ataxia

Friedreichs Ataxia (FA) is the most common inherited ataxia among those of European ancestry. Average age of onset is between 1015 years. It is caused by a mutation in a single gene called Frataxin, which plays an essential role in the mitochondrial iron metabolism. FA is characterized by a slow and progressive loss (=degeneration) of neurons and cardiomyocytes, both cell types that highly depend on mitochondrial metabolism. To date there is no known cure for FA leading to a dramatically reduced life expectancy in affected people. Several recent studies also document inflammation among FA patients, however the main immunological drivers remain unknown. Dr. Mulazzanis research proposal seeks to investigate the link between neuroinflammation and -degeneration, with the hope that this will open novel therapeutic avenues for an otherwise fatal disease.