ERA-NET PathoGenoMics_1.Call_Persistence and immune evasion of Chlamydia pneumoniae

Disciplines

Health Sciences (100%)

Keywords

Persistence, RNA-Interference, Signalling pathways, Chlamydia pneumoniae, Immune evasion, Host-pathogen cross talk

Abstract

The project aims at identifying an a genomic level the host-pathogen crosstalk permitting the frequent pathogen Chlamydia pneumoniae to establish persistent intracellular infection. Major aspects are a) the fine balance of signalling processes required for survival and maintenance of C. pneumoniae inside cells, and b) the cellular mechanisms that cause down-regulation of class I and II antigen presentation, and hence failure in CD8/CD4 T- cell activation. Methodical base is RNA-interference using models established in Salzburg as well as the European RNAi-plattorm provided by the partner in Berlin via ERA-NET PathoGenoMics an base of the input of all partners.