Whole body image analysis for diagnosing patients with monoclonal plasma cell disorders
Whole body image analysis for diagnosing patients with monoclonal plasma cell disorders
Georg Langs
(ORCID: 0000-0002-5536-6873)
DACH: Österreich - Deutschland - Schweiz
Disciplines
Computer Sciences (70%); Clinical Medicine (30%)
Keywords
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Medical Image Analysis,
Oncological Imaging,
Image Processing,
Radiology,
Computer Aided Diagnosis
Whole-body imaging with computed tomography (CT), magnetic resonance imaging (MRI) or positron emission tomography (PET) are increasingly used in staging of monoclonal plasma cell disorders and for evaluating treatment response. These imaging modalities provide localized information about the state of the disease and are a critical addition to blood samples. The enormous amount of data, and the necessity of tracking local disease progress create a substantial challenge for clinical radiologists. This project will develop computer based method that allow for an accurate determination of the disease progression of multiple myeloma patients. The algorithms will detect lesions and will make the entire disease pattern comparable across time and across individuals. On one hand this supports individual diagnosis, on the other it enables the study of links between imaging information and clinical-, molecular-, and genetic parameters.
The DACH project Whole body image analysis for plasma cell disorders, co-funded by FWF (Austria), and DFG (Germany) involved Medical University of Vienna, Technical University of Munich, University of Heidelberg, and University of Rostock. The aim of the project was to develop novel methodology for the assessment, and treatment support of monoclonal plasma cell disorders, with a particular focus on image analysis of multiple myeloma patients. At the Medical University of Vienna, the primary lines of research resulted in novel methods and algorithms for the automatic segmentation of relevant anatomical structures in whole body magnetic resonance imaging (MRI) data, techniques for the mapping of multiple computed tomography and magnetic resonance imaging examinations from multiple time points and multiple patients to a single reference space, and models for the detection and prediction of multiple myeloma lesions from imaging data. The project results contribute to our capability to assess, treat, and investigate monoclonal plasma cell disorders associated with lesions that are visible in MRI.
Research institution(s)
International project participants
- Marc-André Weber, Universitätsklinikum Heidelberg - Germany
- Bjoern H. Menze, University of Zurich - Switzerland
Research Output
- 5979 Citations
- 52 Publications
- 2 Policies
- 2 Artistic Creations
- 3 Methods & Materials
- 1 Datasets & models
- 2 Disseminations
- 4 Scientific Awards
Publications
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2021
Title Analyzing Longitudinal wb-MRI Data and Clinical Course in a Cohort of Former Smoldering Multiple Myeloma Patients: Connections between MRI Findings and Clinical Progression Patterns DOI 10.5167/uzh-214511 Type Other Author Hielscher Link Publication -
2021
Title Spatio-temporal alterations in retinal and choroidal layers in the progression of age-related macular degeneration (AMD) in optical coherence tomography DOI 10.1038/s41598-021-85110-y Type Journal Article Author Vogl W Journal Scientific Reports Pages 5743 Link Publication -
2020
Title Joint embedding: A scalable alignment to compare individuals in a connectivity space DOI 10.1016/j.neuroimage.2020.117232 Type Journal Article Author Nenning K Journal NeuroImage Pages 117232 Link Publication -
2020
Title AI-based prediction of lesion occurrence in high-risk women based on anomalies detected in follow-up examinations DOI 10.1117/12.2564313 Type Conference Proceeding Abstract Author Burger B -
2020
Title Cross-species functional alignment reveals evolutionary hierarchy within the connectome DOI 10.1016/j.neuroimage.2020.117346 Type Journal Article Author Xu T Journal NeuroImage Pages 117346 Link Publication -
2020
Title Spatial Distribution of Focal Lesions in Whole-Body MRI and Influence of MRI Protocol on Staging in Patients with Smoldering Multiple Myeloma According to the New SLiM-CRAB-Criteria DOI 10.3390/cancers12092537 Type Journal Article Author Wennmann M Journal Cancers Pages 2537 Link Publication -
2020
Title Automatic lung segmentation in routine imaging is primarily a data diversity problem, not a methodology problem DOI 10.1186/s41747-020-00173-2 Type Journal Article Author Hofmanninger J Journal European Radiology Experimental Pages 50 Link Publication -
2021
Title Analyzing Longitudinal wb-MRI Data and Clinical Course in a Cohort of Former Smoldering Multiple Myeloma Patients: Connections between MRI Findings and Clinical Progression Patterns DOI 10.3390/cancers13050961 Type Journal Article Author Wennmann M Journal Cancers Pages 961 Link Publication -
2019
Title Causability and explainability of artificial intelligence in medicine DOI 10.1002/widm.1312 Type Journal Article Author Holzinger A Journal Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery Link Publication -
2019
Title f-AnoGAN: Fast unsupervised anomaly detection with generative adversarial networks DOI 10.1016/j.media.2019.01.010 Type Journal Article Author Schlegl T Journal Medical Image Analysis Pages 30-44 -
2019
Title Exploiting Epistemic Uncertainty of Anatomy Segmentation for Anomaly Detection in Retinal OCT DOI 10.48550/arxiv.1905.12806 Type Preprint Author Seeböck P -
2019
Title Using CycleGANs for effectively reducing image variability across OCT devices and improving retinal fluid segmentation DOI 10.48550/arxiv.1901.08379 Type Preprint Author Seeböck P -
2019
Title Asymmetric Cascade Networks for Focal Bone Lesion Prediction in Multiple Myeloma DOI 10.48550/arxiv.1907.13539 Type Preprint Author Licandro R -
2019
Title Additional file 1: of Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features DOI 10.6084/m9.figshare.8051168 Type Other Author Pinker K Link Publication -
2019
Title Additional file 1: of Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features DOI 10.6084/m9.figshare.8051168.v1 Type Other Author Pinker K Link Publication -
2019
Title Exploiting Epistemic Uncertainty of Anatomy Segmentation for Anomaly Detection in Retinal OCT DOI 10.1109/tmi.2019.2919951 Type Journal Article Author Seeböck P Journal IEEE Transactions on Medical Imaging Pages 87-98 Link Publication -
2019
Title Automatic segmentation and classification of breast lesions through identification of informative multiparametric PET/MRI features DOI 10.1186/s41747-019-0096-3 Type Journal Article Author Vogl W Journal European Radiology Experimental Pages 18 Link Publication -
2019
Title Towards Quantitative Imaging Biomarkers of Tumor Dissemination: a Multi-scale Parametric Modeling of Multiple Myeloma DOI 10.1101/613869 Type Preprint Author Piraud M Pages 613869 Link Publication -
2019
Title Using Cyclegans for Effectively Reducing Image Variability Across OCT Devices and Improving Retinal Fluid Segmentation DOI 10.1109/isbi.2019.8759158 Type Conference Proceeding Abstract Author Seeböck P Pages 605-609 Link Publication -
2019
Title Cross-species Functional Alignment Reveals Evolutionary Hierarchy Within the Connectome DOI 10.1101/692616 Type Preprint Author Xu T Pages 692616 Link Publication -
2019
Title Towards quantitative imaging biomarkers of tumor dissemination: A multi-scale parametric modeling of multiple myeloma DOI 10.1016/j.media.2019.07.001 Type Journal Article Author Piraud M Journal Medical Image Analysis Pages 214-225 Link Publication -
2016
Title Identifying and Categorizing Anomalies in Retinal Imaging Data DOI 10.48550/arxiv.1612.00686 Type Preprint Author Seeböck P -
2017
Title Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery DOI 10.48550/arxiv.1703.05921 Type Preprint Author Schlegl T -
2017
Title Additional file 6: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d6 Type Other Author Baumbach S Link Publication -
2017
Title Additional file 6: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d6.v1 Type Other Author Baumbach S Link Publication -
2017
Title Additional file 1: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d1 Type Other Author Baumbach S Link Publication -
2017
Title Additional file 1: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d1.v1 Type Other Author Baumbach S Link Publication -
2017
Title Additional file 2: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d2 Type Other Author Baumbach S Link Publication -
2017
Title Additional file 2: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d2.v1 Type Other Author Baumbach S Link Publication -
2018
Title The DNA methylation landscape of glioblastoma disease progression shows extensive heterogeneity in time and space DOI 10.1038/s41591-018-0156-x Type Journal Article Author Klughammer J Journal Nature Medicine Pages 1611-1624 Link Publication -
2018
Title Predicting Future Bone Infiltration Patterns in Multiple Myeloma DOI 10.1007/978-3-030-00500-9_9 Type Book Chapter Author Licandro R Publisher Springer Nature Pages 76-84 -
2018
Title Detecting Bone Lesions in Multiple Myeloma Patients Using Transfer Learning DOI 10.1007/978-3-030-00807-9_3 Type Book Chapter Author Perkonigg M Publisher Springer Nature Pages 22-30 -
2018
Title Keypoint Transfer for Fast Whole-Body Segmentation DOI 10.1109/tmi.2018.2851194 Type Journal Article Author Wachinger C Journal IEEE Transactions on Medical Imaging Pages 273-282 Link Publication -
2018
Title Unsupervised Identification of Disease Marker Candidates in Retinal OCT Imaging Data DOI 10.1109/tmi.2018.2877080 Type Journal Article Author Seeböck P Journal IEEE Transactions on Medical Imaging Pages 1037-1047 Link Publication -
2018
Title Data Driven Treatment Response Assessment and Preterm, Perinatal, and Paediatric Image Analysis, First International Workshop, DATRA 2018 and Third International Workshop, PIPPI 2018, Held in Conjunction with MICCAI 2018, Granada, Spain, September 16 DOI 10.1007/978-3-030-00807-9 Type Book editors Melbourne A, Licandro R, DiFranco M, Rota P, Gau M, Kampel M, Aughwane R, Moeskops P, Schwartz E, Robinson E, Makropoulos A Publisher Springer Nature -
2018
Title Machine learning: from radiomics to discovery and routine DOI 10.1007/s00117-018-0407-3 Type Journal Article Author Langs G Journal Der Radiologe Pages 1-6 Link Publication -
2018
Title Volumetry based biomarker speed of growth: Quantifying the change of total tumor volume in whole-body magnetic resonance imaging over time improves risk stratification of smoldering multiple myeloma patients DOI 10.18632/oncotarget.25402 Type Journal Article Author Wennmann M Journal Oncotarget Pages 25254-25264 Link Publication -
2020
Title Maschinelles Lernen in der Radiologie DOI 10.1007/s00117-019-00624-x Type Journal Article Author Langs G Journal Der Radiologe Pages 6-14 Link Publication -
2020
Title Dynamic Memory to Alleviate Catastrophic Forgetting in Continuous Learning Settings DOI 10.1007/978-3-030-59713-9_35 Type Book Chapter Author Hofmanninger J Publisher Springer Nature Pages 359-368 -
2020
Title Distributed changes of the functional connectome in patients with glioblastoma DOI 10.1038/s41598-020-74726-1 Type Journal Article Author Nenning K Journal Scientific Reports Pages 18312 Link Publication -
2020
Title Automatic lung segmentation in routine imaging is primarily a data diversity problem, not a methodology problem DOI 10.48550/arxiv.2001.11767 Type Preprint Author Hofmanninger J -
2020
Title Separation of target anatomical structure and occlusions in chest radiographs DOI 10.48550/arxiv.2002.00751 Type Preprint Author Hofmanninger J -
2020
Title Unsupervised deep clustering for predictive texture pattern discovery in medical images DOI 10.48550/arxiv.2002.03721 Type Preprint Author Perkonigg M -
2020
Title Deep learning detection and quantification of pneumothorax in heterogeneous routine chest computed tomography DOI 10.1186/s41747-020-00152-7 Type Journal Article Author Röhrich S Journal European Radiology Experimental Pages 26 Link Publication -
2020
Title Dynamic memory to alleviate catastrophic forgetting in continuous learning settings DOI 10.48550/arxiv.2007.02639 Type Preprint Author Hofmanninger J -
2018
Title Fully Automated Segmentation of Hyperreflective Foci in Optical Coherence Tomography Images DOI 10.48550/arxiv.1805.03278 Type Preprint Author Schlegl T -
2018
Title Unsupervised Identification of Disease Marker Candidates in Retinal OCT Imaging Data DOI 10.48550/arxiv.1810.13404 Type Preprint Author Seeböck P -
2017
Title Unsupervised Anomaly Detection with Generative Adversarial Networks to Guide Marker Discovery DOI 10.1007/978-3-319-59050-9_12 Type Book Chapter Author Schlegl T Publisher Springer Nature Pages 146-157 -
2017
Title Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.1186/s12880-017-0193-9 Type Journal Article Author Baumbach S Journal BMC Medical Imaging Pages 23 Link Publication -
2017
Title Segmentation of Skeleton and Organs in Whole-Body CT Images via Iterative Trilateration DOI 10.1109/tmi.2017.2720261 Type Journal Article Author Bieth M Journal IEEE Transactions on Medical Imaging Pages 2276-2286 -
2017
Title Predicting Macular Edema Recurrence from Spatio-Temporal Signatures in Optical Coherence Tomography Images DOI 10.1109/tmi.2017.2700213 Type Journal Article Author Vogl W Journal IEEE Transactions on Medical Imaging Pages 1773-1783 -
2017
Title Mapping Multi-Modal Routine Imaging Data to a Single Reference via Multiple Templates DOI 10.1007/978-3-319-67558-9_39 Type Book Chapter Author Hofmanninger J Publisher Springer Nature Pages 341-348
Policies
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2020
Title Impact on medical research DOI 10.1016/j.media.2019.07.001 Type Citation in clinical reviews -
2018
Link
Title Scientific Advisory Board: European Institute of Biomedical Imaging Research (EIBIR) - GL DOI 10.1186/s13244-019-0684-z Type Participation in a guidance/advisory committee Link Link
Artistic Creations
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2017
Link
Title Additional file 5: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d5 Type Image Link Link -
2017
Link
Title Additional file 4: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d4 Type Image Link Link
Methods & Materials
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0
Title Algorithm for lesion detection Type Technology assay or reagent -
0
Title Algorithm for predicting emerging and growing lesions in multiple myeloma Type Technology assay or reagent -
2020
Title Algorithm for bone segmentation in magnetic resonance imaging data Type Technology assay or reagent Public Access
Datasets & models
-
2017
Link
Title Additional file 3: of Analysis of the three-dimensional anatomical variance of the distal radius using 3D shape models DOI 10.6084/m9.figshare.c.3712687_d3 Type Database/Collection of data Public Access Link Link
Disseminations
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2020
Link
Title National TV interview ORF 1 Magazin Newton Type A broadcast e.g. TV/radio/film/podcast (other than news/press) Link Link -
2018
Link
Title Data-Driven Treatment Response Assessment Workshop (DATRA 2018) - a MICCAI 2018 satellite event DOI 10.1007/978-3-030-00807-9 Type Participation in an activity, workshop or similar Link Link
Scientific Awards
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2019
Title 23 invited talks presenting project results in 2019 Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2018
Title MICCAI DATRA 2018 Keynote Speaker Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2018
Title 14 invited talks presening project results in 2018 Type Personally asked as a key note speaker to a conference Level of Recognition Continental/International -
2018
Title President of the MICCAI Student Society Type Prestigious/honorary/advisory position to an external body Level of Recognition Continental/International