Role of cell contractility in mesothelioma progression
Role of cell contractility in mesothelioma progression
Balazs Hegedüs
(ORCID: 0000-0002-4341-4153)
Bilaterale Ausschreibung: Ungarn
Disciplines
Biology (40%); Clinical Medicine (30%); Mathematics (30%)
Keywords
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Pleural Mesothelioma,
Actomyosin Contractility,
Tissue Mechanics,
Mathematical Modelling,
Traction Forces,
Pattern Formation
Human malignant pleural mesothelioma (MPM) is a tumor with high mortality. We recently found evidence in cell culture experiments that formation of tumor nodules is driven by cell contractility, instead of increased proliferation. These preliminary observations opened up intriguing possibilities, most importantly improvement in drug delivery by controlling cell contractility. The overall objective of this application is to critically explore these possibilities, and (i) to identify the roles of cell contractility and mechanosensing in MPM progression, (ii) to identify synergistic effects between myosin inhibitors and conventional chemotherapy agents, and (iii) to establish a computational model of the multicellular contraction-driven tumor progression.
Research institution(s)
International project participants
- Andras Czirok, Eötvös University of Sciences Budapest - Hungary
Research Output
- 194 Citations
- 14 Publications
- 1 Methods & Materials
Publications
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2018
Title The FAK inhibitor BI 853520 inhibits spheroid formation and orthotopic tumor growth in malignant pleural mesothelioma DOI 10.1007/s00109-018-1725-7 Type Journal Article Author Laszlo V Journal Journal of Molecular Medicine Pages 231-242 Link Publication -
2017
Title Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma DOI 10.5167/uzh-143003 Type Other Author Klikovits Link Publication -
2018
Title Nintedanib Is Active in Malignant Pleural Mesothelioma Cell Models and Inhibits Angiogenesis and Tumor Growth In Vivo DOI 10.1158/1078-0432.ccr-17-1507 Type Journal Article Author Laszlo V Journal Clinical Cancer Research Pages 3729-3740 Link Publication -
2017
Title Circulating complement component 4d (C4d) correlates with tumor volume, chemotherapeutic response and survival in patients with malignant pleural mesothelioma DOI 10.1038/s41598-017-16551-7 Type Journal Article Author Klikovits T Journal Scientific Reports Pages 16456 Link Publication -
2020
Title Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma DOI 10.1111/his.14105 Type Journal Article Author Bilecz A Journal Histopathology Pages 55-66 Link Publication -
2020
Title Telomerase Reverse Transcriptase Promoter Mutations Identify a Genomically Defined and Highly Aggressive Human Pleural Mesothelioma Subgroup DOI 10.1158/1078-0432.ccr-19-3573 Type Journal Article Author Pirker C Journal Clinical Cancer Research Pages 3819-3830 Link Publication -
2020
Title Tumour cell PD-L1 expression is prognostic in patients with malignant pleural effusion: the impact of C-reactive protein and immune-checkpoint inhibition DOI 10.1038/s41598-020-62813-2 Type Journal Article Author Ghanim B Journal Scientific Reports Pages 5784 Link Publication -
2022
Title Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow DOI 10.21037/tlcr-21-828 Type Journal Article Author Kovacs I Journal Translational Lung Cancer Research Pages 0-0 Link Publication -
2021
Title Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study DOI 10.21037/tlcr-20-1114 Type Journal Article Author Brcic L Journal Translational Lung Cancer Research Pages 1594-1607 Link Publication -
2019
Title Detection of TGF-ß in pleural effusions for diagnosis and prognostic stratification of malignant pleural mesothelioma DOI 10.1016/j.lungcan.2019.11.013 Type Journal Article Author Stockhammer P Journal Lung Cancer Pages 124-132 -
2023
Title LA-ICP-MS analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma DOI 10.22541/au.167275573.37513553/v1 Type Preprint Author Tisza A Link Publication -
2023
Title Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma DOI 10.1111/bcp.15813 Type Journal Article Author Tisza A Journal British Journal of Clinical Pharmacology Pages 3364-3374 Link Publication -
2020
Title Multicellular contractility contributes to the emergence of mesothelioma nodules DOI 10.1038/s41598-020-76641-x Type Journal Article Author Tarnoki-Zach J Journal Scientific Reports Pages 20114 Link Publication -
2021
Title Clinical relevance of circulating activin A and follistatin in small cell lung cancer DOI 10.1016/j.lungcan.2021.09.008 Type Journal Article Author Barany N Journal Lung Cancer Pages 128-135 Link Publication
Methods & Materials
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0
Title Novel patient derived mesothelioma cell models Type Cell line Public Access