The role of nuclear factor kappa B and its possible action as an antiprogestogen

The role of nuclear factor kappa B and its possible action as an antiprogestogen

Doris Pieber (ORCID: )

Disciplines

Clinical Medicine (34%); Medical-Theoretical Sciences, Pharmacy (66%)

Keywords

    PRETERM LABOUR, NFKB, INFLAMMATORY MEDIATORS, PROGESTERON RECEPTOR

Abstract

Preterm labour remains a major problem in obstetrics, but the mechanisms of preterm labour are not fully understood. This work should clarify whether NFkB (nuclear factor kappa B) plays an important role in the onset of term and preterm labour, by increasing the of prostaglandins and interleukines. In addition the hypothesis will be tested, that NFkB is responsible for the induction of labour by inhibiting the tocolytic action of progesterone through downregulation of the progesterone receptor.
Research institution(s)