Characterization of the Intracellular Degradation of Methotrexate Polyglutamates in Blasts from Childhood Acute Lymphoblastic Leukemia
Characterization of the Intracellular Degradation of Methotrexate Polyglutamates in Blasts from Childhood Acute Lymphoblastic Leukemia
Leo Kager
(ORCID: 0000-0003-4954-6488)
Disciplines
Clinical Medicine (50%); Medical-Theoretical Sciences, Pharmacy (50%)
Keywords
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METHOTREXATE,
ACUTE LYMPHOBLASTIC LEUKEMIA,
PLOIDY AND LINEAGE DIFFERENCES,
GAMMA-GLUTAMYL-HYDROLASE,
CHILDHOOD,
INTRACELLULAR METABOLISM
Research institution(s)
Research Output
- 141 Citations
- 1 Publications
Publications
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2005
Title Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics DOI 10.1172/jci22477 Type Journal Article Author Kager L Journal Journal of Clinical Investigation Pages 110-117 Link Publication