Investigation of neurobiology behind painful neuroma

Neuropathic pain is a type of chronic pain that affects a lot of people and makes life hard. One specific kind of this pain, called painful neuroma, happens when damaged nerves grow out of control after an injury. We`re trying to understand why this happens and how surgery can help. This project aims to figure out what causes pain in painful neuromas and how surgery can relieve this pain. We`re doing two trials, one with people and one with animals. In the human trial, we`re studying painful neuromas from patients who had surgery and comparing them to healthy nerves. In the animal trial, we`re making painful neuromas in nerves and then treating them with surgery to see what changes. This project will provide new insights into the causes of painful neuromas, the connection between pain-related genes and immune cells, and the experience of pain. This knowledge could lead to better treatments. We`ll also learn more about the effectiveness of surgery in treating painful neuromas and how it changes nerve function, potentially leading to improved pain relief.