Virtual and Augmented Reality Module for 3D Reconstruction
Virtual and Augmented Reality Module for 3D Reconstruction
Disciplines
Computer Sciences (10%); Clinical Medicine (40%); Medical Engineering (30%); Environmental Engineering, Applied Geosciences (20%)
Keywords
-
Maxillofacial Surgery,
Bone Defect Reconstruction,
Segmentation,
Navigation,
Augmented and Virtual Reality,
3D Printed Implant
This interdisciplinary research project between computer science and medicine targets the development of a comprehensive image-guided tool for head and neck surgery with the main focus on mandibular fractures and mid-facial fractures. The tool supports the physicians in all treatment stages (diagnosis, planning, intervention and monitoring) and can also be used during clinical traineeship. A key point is the development of an algorithm for the semi-automatic and automatic segmentation of bone structures and soft tissue in CT and MRI acquisitions. A segmentation enables a three-dimensional localization, quantification and visualization of biological structures in a very short time. Based on the radiological images from the clinical routine, treatment diagnosis can be visualized, and surgical planning processes or alternative surgery options can be simulated. In addition, the postoperative simulation results can be presented preoperatively in a photo-realistic manner. In particular, this will be applied in the reposition of bony structures, the reconstruction of facial defects and the removal of tumors in complex anatomical areas. Moreover, we plan the development of patient-individual three-dimensional implants, which will 3D printed in- house for comparison with the external manufactured ones and for clinical usage. Furthermore, the medical personnel can be supported in real-time during surgery by an interactive navigation, where Augmented Reality integrates computer-generated objects into the operation field. The application reduces surgical complications and ensures a successful treatment result by pre- and intraoperative simulations. Hence, the number of necessary corrective surgeries and the operation time needed can be reduced, and a higher patient survival rate can be achieved. In addition, the combination with Virtual Reality glasses allows the virtual training of operations during medical education. The objective of the project is the establishment of an open source tool as basis for further research and developments for the participating universities. Currently, comparable tools are protected by strict licensing conditions and not accessible without restrictions for academic research. Existing software for clinical practice is not functionally stable enough and has too high error rates. Additionally, the usage imposes high financial costs, which makes a widespread application not possible. Finally, Augmented Reality in the clinical routine is an important topic for current surgical research and cannot be ignored by modern medical universities.
In this interdisciplinary research project between computer science and medicine, image-supported tools for head and neck surgery were developed, which support physicians in all medical phases (diagnosis, operation planning, intervention and control), but can also be used in teaching. One aspect of the project was the development of algorithms for the semi-automatic and automatic segmentation of bony structures and soft tissue based on CT and MRI data sets. The segmentation enables the three-dimensional localization, quantification and visualization of anatomical structures in a short time. Based on radiological image data from the clinical routine, treatment plans can be quickly visualized, and surgical planning processes or operative treatment options can be simulated. This is mainly used in the repositioning of bony structures, in the reconstruction of facial defects and in the removal of tumors in areas with complex anatomy. Furthermore, an augmented reality (AR) tool was developed with which the medical staff can be supported in real time by interactive visualization and navigation, even during an intervention. Using AR, virtual, computer-generated objects can be integrated into the real, physical surroundings. With the developed tool, anatomical structures and planning information are visualized directly on the patient, pre- or intra-operatively, and surgeons are guided interactively to the target anatomy. This can reduce surgical complications and ensure a successful treatment outcome. Consequently, the number of necessary corrective operations and the required operating time can be reduced. As part of the project, open-source applications were created as a basis for the further development at the participating universities. Similar applications are currently protected by strict licenses and are not fully accessible to academic research.
- Technische Universität Graz - 100%
- Jan Egger, Medizinische Universität Graz , former principal investigator
- Jürgen Wallner, Medizinische Universität Graz , former principal investigator
- Dieter Schmalstieg, Technische Universität Graz , associated research partner
- Xiaojun Chen, Shanghai Jiao Tong University - China
- Malgorzata Kolodziej, Justus-Liebig-Universität Gießen - Germany
- Ti-Chiun Chang, Siemens Corporate Research - USA
Research Output
- 1617 Citations
- 76 Publications
- 5 Datasets & models
-
2024
Title GAN-based generation of realistic 3D volumetric data: A systematic review and taxonomy. DOI 10.1016/j.media.2024.103100 Type Other Author Ferreira A Pages 103100 -
2024
Title Back to the Roots: Reconstructing Large and Complex Cranial Defects using an Image-based Statistical Shape Model. DOI 10.1007/s10916-024-02066-y Type Journal Article Author Ellis Dg Journal Journal of medical systems Pages 55 -
2020
Title A Baseline Approach for AutoImplant: the MICCAI 2020 Cranial Implant Design Challenge DOI 10.48550/arxiv.2006.12449 Type Preprint Author Li J -
2020
Title Biofunctional Glycol-Modified Polyethylene Terephthalate and Thermoplastic Polyurethane Implants by Extrusion-Based Additive Manufacturing for Medical 3D Maxillofacial Defect Reconstruction DOI 10.3390/polym12081751 Type Journal Article Author Katschnig M Journal Polymers Pages 1751 Link Publication -
2020
Title Design and Development of a Web-based Tool for Inpainting of Dissected Aortae in Angiography Images DOI 10.48550/arxiv.2005.02760 Type Preprint Author Prutsch A -
2020
Title An Online Platform for Automatic Skull Defect Restoration and Cranial Implant Design DOI 10.48550/arxiv.2006.00980 Type Preprint Author Li J -
2020
Title A Baseline Approach for AutoImplant: The MICCAI 2020 Cranial Implant Design Challenge DOI 10.1007/978-3-030-60946-7_8 Type Book Chapter Author Li J Publisher Springer Nature Pages 75-84 -
2020
Title Detection, segmentation, simulation and visualization of aortic dissections: A review DOI 10.1016/j.media.2020.101773 Type Journal Article Author Pepe A Journal Medical Image Analysis Pages 101773 -
2020
Title Semi-supervised Virtual Regression of Aortic Dissections Using 3D Generative Inpainting DOI 10.1007/978-3-030-62469-9_12 Type Book Chapter Author Pepe A Publisher Springer Nature Pages 130-140 -
2020
Title Augmented Reality for Head and Neck Carcinoma Imaging: Description and Feasibility of an Instant Calibration, Markerless Approach DOI 10.1016/j.cmpb.2020.105854 Type Journal Article Author Gsaxner C Journal Computer Methods and Programs in Biomedicine Pages 105854 -
2020
Title Single-Shot Deep Volumetric Regression for Mobile Medical Augmented Reality DOI 10.1007/978-3-030-60946-7_7 Type Book Chapter Author Karner F Publisher Springer Nature Pages 64-74 -
2020
Title High-Resolution Cranial Implant Prediction via Patch-Wise Training DOI 10.1007/978-3-030-64327-0_11 Type Book Chapter Author Jin Y Publisher Springer Nature Pages 94-103 -
2020
Title Dataset Descriptor for the AutoImplant Cranial Implant Design Challenge DOI 10.1007/978-3-030-64327-0_2 Type Book Chapter Author Li J Publisher Springer Nature Pages 10-15 -
2019
Title Depth-Awareness in a System for Mixed-Reality Aided Surgical Procedures DOI 10.1007/978-3-030-26766-7_65 Type Book Chapter Author Sylos Labini M Publisher Springer Nature Pages 716-726 -
2019
Title Exploit fully automatic low-level segmented PET data for training high-level deep learning algorithms for the corresponding CT data DOI 10.48550/arxiv.1903.02871 Type Preprint Author Gsaxner C -
2019
Title Client/Server Based Online Environment for Manual Segmentation of Medical Images DOI 10.48550/arxiv.1904.08610 Type Preprint Author Wild D -
2019
Title Facial model collection for medical augmented reality in oncologic cranio-maxillofacial surgery DOI 10.1038/s41597-019-0327-8 Type Journal Article Author Gsaxner C Journal Scientific Data Pages 310 Link Publication -
2022
Title AVT: Multicenter aortic vessel tree CTA dataset collection with ground truth segmentation masks DOI 10.1016/j.dib.2022.107801 Type Journal Article Author Radl L Journal Data in Brief Pages 107801 Link Publication -
2022
Title Studierfenster: an Open Science Cloud-Based Medical Imaging Analysis Platform DOI 10.1007/s10278-021-00574-8 Type Journal Article Author Egger J Journal Journal of Digital Imaging Pages 340-355 Link Publication -
2022
Title k-strip: A novel segmentation algorithm in k-space for the application of skull stripping DOI 10.48550/arxiv.2205.09706 Type Preprint Author Rempe M -
2022
Title Medical deep learning—A systematic meta-review DOI 10.1016/j.cmpb.2022.106874 Type Journal Article Author Egger J Journal Computer Methods and Programs in Biomedicine Pages 106874 Link Publication -
2022
Title Back to the Roots: Reconstructing Large and Complex Cranial Defects using an Image-based Statistical Shape Model DOI 10.48550/arxiv.2204.05703 Type Preprint Author Li J -
2022
Title Radiomics in head and neck cancer outcome predictions DOI 10.18154/rwth-conv-250627 Type Other Author Gonçalves M Link Publication -
2022
Title Back to the Roots: Reconstructing Large and Complex Cranial Defects using an Image-based Statistical Shape Model DOI 10.36227/techrxiv.19582846 Type Preprint Author Ellis D -
2019
Title Automated Computer-aided Design of Cranial Implants Using a Deep Volumetric Convolutional Denoising Autoencoder DOI 10.1007/978-3-030-16187-3_15 Type Book Chapter Author Morais A Publisher Springer Nature Pages 151-160 -
2019
Title A Client/Server based Online Environment for the Calculation of Medical Segmentation Scores DOI 10.1109/embc.2019.8856481 Type Conference Proceeding Abstract Author Weber M Pages 3463-3467 -
2019
Title Using Synthetic Training Data for Deep Learning-Based GBM Segmentation DOI 10.1109/embc.2019.8856297 Type Conference Proceeding Abstract Author Lindner L Pages 6724-6729 -
2021
Title Inside-Out Instrument Tracking for Surgical Navigation in Augmented Reality DOI 10.1145/3489849.3489863 Type Conference Proceeding Abstract Author Gsaxner C Pages 1-11 -
2021
Title Deep learning—a first meta-survey of selected reviews across scientific disciplines, their commonalities, challenges and research impact DOI 10.7717/peerj-cs.773 Type Journal Article Author Egger J Journal PeerJ Computer Science Link Publication -
2021
Title Learning to Rearrange Voxels in Binary Segmentation Masks for Smooth Manifold Triangulation DOI 10.1007/978-3-030-92652-6_5 Type Book Chapter Author Li J Publisher Springer Nature Pages 45-62 -
2021
Title MUG500+: Database of 500 high-resolution healthy human skulls and 29 craniotomy skulls and implants DOI 10.1016/j.dib.2021.107524 Type Journal Article Author Li J Journal Data in Brief Pages 107524 Link Publication -
2021
Title Effects of Pre-Operative Risk Factors on Intensive Care Unit Length of Stay (ICU-LOS) in Major Oral and Maxillofacial Cancer Surgery DOI 10.3390/cancers13163937 Type Journal Article Author Wallner J Journal Cancers Pages 3937 Link Publication -
2020
Title Deep Learning -- A first Meta-Survey of selected Reviews across Scientific Disciplines, their Commonalities, Challenges and Research Impact DOI 10.48550/arxiv.2011.08184 Type Preprint Author Egger J -
2020
Title A review on the applications of virtual reality, augmented reality and mixed reality in surgical simulation: an extension to different kinds of surgery DOI 10.1080/17434440.2021.1860750 Type Journal Article Author Lungu A Journal Expert Review of Medical Devices Pages 47-62 -
2023
Title Why does my medical AI look at pictures of birds? Exploring the efficacy of transfer learning across domain boundaries DOI 10.48550/arxiv.2306.17555 Type Other Author Jonske F Link Publication -
2022
Title The HoloLens in Medicine: A systematic Review and Taxonomy DOI 10.48550/arxiv.2209.03245 Type Preprint Author Gsaxner C -
2018
Title Pattern Recognition and Mixed Reality for Computer-Aided Maxillofacial Surgery and Oncological Assessment DOI 10.1109/bmeicon.2018.8609921 Type Conference Proceeding Abstract Author Pepe A Pages 1-5 -
2024
Title Brain Tumour Removing and Missing Modality Generation using 3D WDM DOI 10.48550/arxiv.2411.04630 Type Preprint Author Ferreira A Link Publication -
2024
Title Improved Multi-Task Brain Tumour Segmentation with Synthetic Data Augmentation DOI 10.48550/arxiv.2411.04632 Type Preprint Author Ferreira A Link Publication -
2024
Title k-strip: A novel segmentation algorithm in k-space for the application of skull stripping. DOI 10.1016/j.cmpb.2023.107912 Type Journal Article Author Mentzel F Journal Computer methods and programs in biomedicine Pages 107912 -
2023
Title The HoloLens in medicine: A systematic review and taxonomy. DOI 10.1016/j.media.2023.102757 Type Other Author Gsaxner C Pages 102757 -
2022
Title Gender-specific differences in haemostatic parameters and their influence on blood loss in bimaxillary surgery DOI 10.1007/s00784-021-04347-z Type Journal Article Author Schwaiger M Journal Clinical Oral Investigations Pages 3765-3779 Link Publication -
2022
Title Back to the Roots: Reconstructing Large and Complex Cranial Defects using an Image-based Statistical Shape Model DOI 10.36227/techrxiv.19582846.v1 Type Preprint Author Ellis D -
2022
Title Radiomics in Head and Neck Cancer Outcome Predictions DOI 10.3390/diagnostics12112733 Type Journal Article Author Gonçalves M Journal Diagnostics Pages 2733 Link Publication -
2022
Title Open-Source Skull Reconstruction with MONAI DOI 10.48550/arxiv.2211.14051 Type Preprint Author Li J -
2021
Title AI-based Aortic Vessel Tree Segmentation for Cardiovascular Diseases Treatment: Status Quo DOI 10.48550/arxiv.2108.02998 Type Preprint Author Jin Y -
2021
Title Synthetic skull bone defects for automatic patient-specific craniofacial implant design DOI 10.1038/s41597-021-00806-0 Type Journal Article Author Li J Journal Scientific Data Pages 36 Link Publication -
2021
Title AutoImplant 2020-First MICCAI Challenge on Automatic Cranial Implant Design DOI 10.1109/tmi.2021.3077047 Type Journal Article Author Li J Journal IEEE Transactions on Medical Imaging Pages 2329-2342 -
2018
Title Human upper-body inverse kinematics for increased embodiment in consumer-grade virtual reality DOI 10.1145/3281505.3281529 Type Conference Proceeding Abstract Author Parger M Pages 1-10 -
2018
Title PET-Train: Automatic Ground Truth Generation from PET Acquisitions for Urinary Bladder Segmentation in CT Images using Deep Learning DOI 10.1109/bmeicon.2018.8609954 Type Conference Proceeding Abstract Author Gsaxner C Pages 1-5 -
2018
Title Clinical evaluation of semi-automatic opensource algorithmic software segmentation of the mandibular bone: Practical feasibility and assessment of a new course of action DOI 10.48550/arxiv.1805.08604 Type Preprint Author Wallner J -
2018
Title Anatomy of the Le Fort I segment: Are arterial variations a potential risk factor for avascular bone necrosis in Le Fort I osteotomies? DOI 10.1016/j.jcms.2018.04.023 Type Journal Article Author Bruneder S Journal Journal of Cranio-Maxillofacial Surgery Pages 1285-1295 -
2018
Title Clinical evaluation of semi-automatic open-source algorithmic software segmentation of the mandibular bone: Practical feasibility and assessment of a new course of action DOI 10.1371/journal.pone.0196378 Type Journal Article Author Wallner J Journal PLOS ONE Link Publication -
2023
Title Open-source skull reconstruction with MONAI DOI 10.18154/rwth-conv-252675 Type Other Author Ferreira A Link Publication -
2023
Title Open-source skull reconstruction with MONAI DOI 10.1016/j.softx.2023.101432 Type Journal Article Author Ferreira A Journal SoftwareX -
2023
Title Automated cross-sectional view selection in CT angiography of aortic dissections with uncertainty awareness and retrospective clinical annotations. DOI 10.1016/j.compbiomed.2023.107365 Type Journal Article Author Egger J Journal Computers in biology and medicine Pages 107365 -
2021
Title Automatic skull defect restoration and cranial implant generation for cranioplasty DOI 10.1016/j.media.2021.102171 Type Journal Article Author Li J Journal Medical Image Analysis Pages 102171 -
2021
Title Learning to Rearrange Voxels in Binary Segmentation Masks for Smooth Manifold Triangulation DOI 10.48550/arxiv.2108.05269 Type Preprint Author Li J -
2021
Title A review on patient-specific facial and cranial implant design using Artificial Intelligence (AI) techniques DOI 10.1080/17434440.2021.1969914 Type Journal Article Author Memon A Journal Expert Review of Medical Devices Pages 985-994 -
2021
Title An online platform for automatic skull defect restoration and cranial implant design DOI 10.1117/12.2580719 Type Conference Proceeding Abstract Author Li J Pages 59 Link Publication -
2021
Title SkullBreak / SkullFix – Dataset for automatic cranial implant design and a benchmark for volumetric shape learning tasks DOI 10.1016/j.dib.2021.106902 Type Journal Article Author Kodym O Journal Data in Brief Pages 106902 Link Publication -
2021
Title Sparse Convolutional Neural Network for Skull Reconstruction DOI 10.1007/978-3-030-92652-6_7 Type Book Chapter Author Kroviakov A Publisher Springer Nature Pages 80-94 -
2021
Title PCA-Skull: 3D Skull Shape Modelling Using Principal Component Analysis DOI 10.1007/978-3-030-92652-6_9 Type Book Chapter Author Yu L Publisher Springer Nature Pages 105-115 -
2021
Title Automated cross-sectional view selection in CT angiography of aortic dissections with uncertainty awareness and retrospective clinical annotations DOI 10.48550/arxiv.2111.11269 Type Preprint Author Pepe A -
2020
Title Towards the Automatization of Cranial Implant Design in Cranioplasty - First Challenge, AutoImplant 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 8, 2020, Proceedings DOI 10.1007/978-3-030-64327-0 Type Book editors Li J, Egger J Publisher Springer International Publishing -
2020
Title Medical Deep Learning -- A systematic Meta-Review DOI 10.48550/arxiv.2010.14881 Type Preprint Author Egger J -
2020
Title Differences in adhesion between 1C-PUR and MUF wood adhesives to (ligno)cellulosic surfaces revealed by nanoindentation DOI 10.1016/j.ijadhadh.2019.102507 Type Journal Article Author Herzele S Journal International Journal of Adhesion and Adhesives Pages 102507 Link Publication -
2020
Title A review on computer-aided design and manufacturing of patient-specific maxillofacial implants DOI 10.1080/17434440.2020.1736040 Type Journal Article Author Memon A Journal Expert Review of Medical Devices Pages 345-356 Link Publication -
2016
Title Drug trapping in hERG K + channels: (not) a matter of drug size? DOI 10.1039/c5md00443h Type Journal Article Author Linder T Journal MedChemComm Pages 512-518 Link Publication -
2019
Title A review on multiplatform evaluations of semi-automatic open-source based image segmentation for cranio-maxillofacial surgery DOI 10.1016/j.cmpb.2019.105102 Type Journal Article Author Wallner J Journal Computer Methods and Programs in Biomedicine Pages 105102 -
2019
Title A Marker-Less Registration Approach for Mixed Reality–Aided Maxillofacial Surgery: a Pilot Evaluation DOI 10.1007/s10278-019-00272-6 Type Journal Article Author Pepe A Journal Journal of Digital Imaging Pages 1008-1018 Link Publication -
2019
Title Markerless Image-to-Face Registration for Untethered Augmented Reality in Head and Neck Surgery DOI 10.1007/978-3-030-32254-0_27 Type Book Chapter Author Gsaxner C Publisher Springer Nature Pages 236-244 -
2019
Title Computed tomography data collection of the complete human mandible and valid clinical ground truth models DOI 10.1038/sdata.2019.3 Type Journal Article Author Wallner J Journal Scientific Data Pages 190003 Link Publication -
2019
Title Exploit fully automatic low-level segmented PET data for training high-level deep learning algorithms for the corresponding CT data DOI 10.1371/journal.pone.0212550 Type Journal Article Author Gsaxner C Journal PLOS ONE Link Publication -
2019
Title Free thoracodorsal, perforator-scapular flap based on the angular artery (TDAP-Scap-aa): Clinical experiences and description of a novel technique for single flap reconstruction of extensive oromandibular defects DOI 10.1016/j.jcms.2019.07.021 Type Journal Article Author Pau M Journal Journal of Cranio-Maxillofacial Surgery Pages 1617-1625 -
2016
Title Uncertainty budgeting in fold change determination and implications for non-targeted metabolomics studies in model systems DOI 10.1039/c6an01342b Type Journal Article Author Ortmayr K Journal Analyst Pages 80-90
-
2021
Link
Title Metadata record for: Synthetic skull bone defects for automatic patient-specific craniofacial implant design DOI 10.6084/m9.figshare.13265225 Type Database/Collection of data Public Access Link Link -
2021
Link
Title MUG500+ Repository DOI 10.6084/m9.figshare.9616319.v19 Type Database/Collection of data Public Access Link Link -
2020
Link
Title Metadata record for: Facial model collection for medical augmented reality in oncologic cranio-maxillofacial surgery DOI 10.6084/m9.figshare.11284757 Type Database/Collection of data Public Access Link Link -
2019
Link
Title Medical Augmented Reality Facial Data Collection DOI 10.6084/m9.figshare.8857007.v2 Type Database/Collection of data Public Access Link Link -
2019
Link
Title Mandibular CT Dataset Collection DOI 10.6084/m9.figshare.6167726.v6 Type Database/Collection of data Public Access Link Link