Disciplines
Chemistry (80%); Medical-Theoretical Sciences, Pharmacy (10%); Physics, Astronomy (10%)
Keywords
Antibiotics,
Ansa Structures,
Quinonmethide,
Stereoselective Synthesis,
Antistereoporotic Drug,
Trost-Tsuji
Abstract
A total synthesis of kendomycin is suggested. The compound is highly interesting from practical standpoint, as it is
a nover highly potent antibiotic and has additional biological activities, such as antiosteoporotic and endothelin
receptor binding properties. Additionally, it belongs to a structurally unprecedented type, having an all carbon
answer chain connected to quinomethide core. Our group has already been working on a total synthesis of
kendomycin for about one year, however the synthesis is far from completion. Michael Green has suggested an
interesting new approach which is entirely his own making. The new synthesis focuses on C-aryl glycoside
chemistry and will complement the current strategy very nicely, as it is far more direct and shorter than our own
route.