A novel miRNA in the GAP43 gene regulating neuroregeneration
A novel miRNA in the GAP43 gene regulating neuroregeneration
Disciplines
Biology (80%); Medical-Theoretical Sciences, Pharmacy (10%); Medical Biotechnology (10%)
Keywords
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Mirna,
GAP43,
Dorsal Root Ganglia,
Neuronal Injury,
Neuronal Regeneration
MicroRNAs (miRNAs) are small non-coding RNA molecules that can control the expression of a variety of genes. Alterations in miRNA expression patterns have been identified as biomarkers for many diseases, making them promising targets for therapeutic interventions. We recently showed that a previously not described miRNA - GAPmiR - was significantly increased in mouse sensory neurons after experimental nerve injury. Therefore, the overall goal of the GAPmiR project is to identify the mechanisms that contribute to the upregulation of GAPmiR as well as elucidating its role in neuronal regeneration after injury. This will provide new insights into the function of a new miRNA and contribute to the development of novel therapeutics in neuroregenerative medicine.
- Kai Kummer, Medizinische Universität Innsbruck , national collaboration partner
- Maximilian Zeidler, Medizinische Universität Innsbruck , national collaboration partner
- Michaela Kress, Medizinische Universität Innsbruck , national collaboration partner
Research Output
- 1 Publications
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2025
Title Repeated testing and housing conditions impact complex mouse behaviors independently of surgical interventions DOI 10.1016/j.brainresbull.2025.111598 Type Journal Article Author Riehl L Journal Brain Research Bulletin Pages 111598 Link Publication