Disciplines
Biology (80%); Medical-Theoretical Sciences, Pharmacy (10%); Medical Biotechnology (10%)
Keywords
Mirna,
GAP43,
Dorsal Root Ganglia,
Neuronal Injury,
Neuronal Regeneration
Abstract
MicroRNAs (miRNAs) are small non-coding RNA molecules that can control the expression of a variety
of genes. Alterations in miRNA expression patterns have been identified as biomarkers for many
diseases, making them promising targets for therapeutic interventions.
We recently showed that a previously not described miRNA - GAPmiR - was significantly increased in
mouse sensory neurons after experimental nerve injury. Therefore, the overall goal of the GAPmiR
project is to identify the mechanisms that contribute to the upregulation of GAPmiR as well as
elucidating its role in neuronal regeneration after injury. This will provide new insights into the function
of a new miRNA and contribute to the development of novel therapeutics in neuroregenerative
medicine.