SHUTTLE – Hydride Shuttle Catalysis

While the funcon of chemical structures is not inherently based on their complexity, with many successful pharmaceucals being rather simple compounds, more elaborate structures hold much promise. Parcularly, oen even slight alteraons to chemical structure can elicit profound changes in biological acvity. Among such compounds, those containing nitrogen atoms within a cyclic structure are parcularly interesng and the development of more ecient syntheses remains of the highest importance. Drawing on the foundaon laid by previous work developed in our group, we propose the development of a range of new reacons, which are based on a concept termed inverse hydride shutle catalysis. This concept underpins a spectrum of novel reacons designed to yield a diverse array of products. Yet, while potenally giving access of a wide variety of dierent products, our proposed reacons can be comprehensively categorised as i) taking advantage of the rapid aggregaon of simple, and oen commercially available, starng materials, ii) employing metal-free catalysts for the selecve modicaon of nitrogen-containing structures and iii) delivering (poly)cyclic compounds with high complexity. Although the foundaonal principles of this concept have been elucidated in earlier work, our proposed endeavours aim to extend and generalize this process. Integraon with other reacons is pivotal, promising the generaon of heavily funconalized products with versale applicaons across various elds. The envisioned outcome is a streamlined and versale methodology that capitalizes on the "inverse hydride shutle catalysis" framework, and will give rise to much more heavily funconalised products with potenal applicaons in a wide variety of elds. This research project aspires to posion "inverse hydride shutle catalysis" as a universally applicable method, oering researchers across natural sciences and beyond a tool for the rapid synthesis of structures that were once beyond reach. The prospect of facilitang the exploraon of uncharted chemical territories underscores the broader impact of this methodology, transcending disciplinary boundaries and contribung to the advancement of scienc knowledge.