Metabolic signaling in sarcoidosis

Sarcoidosis is a disease where small clusters of immune cellscalled granulomasform in different organs, often leading to inflammation, tissue damage, and scarring (fibrosis). While we know that certain immune cells, especially macrophages and T cells, play a central role in forming these granulomas, it remains unclear what triggers them to behave abnormally in the first place. This project explores the idea that changes in how immune cells process nutrients and chemical signalswhat we call "metabolic signaling"may be a key driver of granuloma formation and disease progression in sarcoidosis. Specifically, the research will investigate how molecules called monoamines might influence immune cell behavior and contribute to inflammation and fibrosis. By uncovering new biological mechanisms behind sarcoidosis, this research could lead to innovative treatments that target the root causes of inflammation and fibrosis and not just the symptoms, thereby offering new hope for patients affected by this complex disease.