Disciplines
Biology (15%); Clinical Medicine (15%); Medical-Theoretical Sciences, Pharmacy (70%)
Keywords
- Lung adenocarcinoma,
- EGFR mutation,
- Immunosurveillance,
- Immunotherapy,
- Genetically Engineered Mouse Model (GEMM)
Abstract
Lung adenocarcinoma (LUAD) with EGFR mutations often resists immunotherapy because
tumors lack cytotoxic T cells. This immune desert phenotype is due to a process called immune
evasion, where tumors avoid detection by the immune system.
We use a mouse model that mimics human EGFR-mutated LUAD to study how T cells disappear
as tumors progress. By analyzing tumors at different stages, we aim to find the signals driving
tumor immune escape.
Our goal is to block these signals and restore tumor T cell infiltration, making immunotherapy
work better for patients with EGFR-mutant lung cancer.