Molecular Cell Biology and Oncology

Molecular Cell Biology and Oncology

Bernhard E. Flucher (ORCID: 0000-0002-5255-4705)

Disciplines

Biology (20%); Medical-Theoretical Sciences, Pharmacy (80%)

Consortium
Research institution(s)
  • Universität Innsbruck
  • Medizinische Universität Innsbruck
Project participants
International project participants

Research Output

  • 18008 Citations
  • 242 Publications
Publications
  • 2023
    Title The lysosomal LAMTOR / Ragulator complex is essential for nutrient homeostasis in brown adipose tissue
    DOI 10.1016/j.molmet.2023.101705
    Type Journal Article
    Author Liebscher G
    Journal Molecular Metabolism
    Pages 101705
    Link Publication
  • 2020
    Title Stabilization of negative activation voltages of Cav1.3 L-Type Ca2+-channels by alternative splicing
    DOI 10.1080/19336950.2020.1859260
    Type Journal Article
    Author Hofer N
    Journal Channels
    Pages 38-52
    Link Publication
  • 2020
    Title Spliced XBP1 Levels Determine Sensitivity of Multiple Myeloma Cells to Proteasome Inhibitor Bortezomib Independent of the Unfolded Protein Response Mediator GRP78
    DOI 10.3389/fonc.2019.01530
    Type Journal Article
    Author Borjan B
    Journal Frontiers in Oncology
    Pages 1530
    Link Publication
  • 2020
    Title E2F-Family Members Engage the PIDDosome to Limit Hepatocyte Ploidy in Liver Development and Regeneration
    DOI 10.1016/j.devcel.2019.12.016
    Type Journal Article
    Author Sladky V
    Journal Developmental Cell
    Link Publication
  • 2020
    Title Uncovering the PIDDosome and caspase-2 as regulators of organogenesis and cellular differentiation
    DOI 10.1038/s41418-020-0556-6
    Type Journal Article
    Author Sladky V
    Journal Cell Death & Differentiation
    Pages 2037-2047
    Link Publication
  • 2020
    Title PIDDosome-induced p53-activation for ploidy restriction facilitates hepatocarcinogenesis
    DOI 10.1101/2020.05.13.092486
    Type Preprint
    Author Sladky V
    Pages 2020.05.13.092486
    Link Publication
  • 2019
    Title Endosome and Golgi-associated degradation (EGAD) of membrane proteins regulates sphingolipid metabolism
    DOI 10.15252/embj.2018101433
    Type Journal Article
    Author Schmidt O
    Journal The EMBO Journal
    Link Publication
  • 2019
    Title Checkpoint kinase 1 is essential for fetal and adult hematopoiesis
    DOI 10.15252/embr.201847026
    Type Journal Article
    Author Schuler F
    Journal The EMBO Reports
    Link Publication
  • 2018
    Title Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b
    DOI 10.3389/fimmu.2018.02311
    Type Journal Article
    Author Peer S
    Journal Frontiers in Immunology
    Pages 2311
    Link Publication
  • 2018
    Title Checkpoint kinase 1 is essential for establishing fetal haematopoiesis and hematopoietic stem and progenitor cell survival
    DOI 10.1101/413310
    Type Preprint
    Author Schuler F
    Pages 413310
    Link Publication
  • 2018
    Title Gating defects of disease-causing de novo mutations in Cav1.3 Ca2+ channels
    DOI 10.1080/19336950.2018.1546518
    Type Journal Article
    Author Pinggera A
    Journal Channels
    Pages 388-402
    Link Publication
  • 2018
    Title Calcium Influx and Release Cooperatively Regulate AChR Patterning and Motor Axon Outgrowth during Neuromuscular Junction Formation
    DOI 10.1016/j.celrep.2018.05.085
    Type Journal Article
    Author Kaplan M
    Journal Cell Reports
    Pages 3891-3904
    Link Publication
  • 2018
    Title STAC proteins: The missing link in skeletal muscle EC coupling and new regulators of calcium channel function
    DOI 10.1016/j.bbamcr.2018.12.004
    Type Journal Article
    Author Flucher B
    Journal Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
    Pages 1101-1110
    Link Publication
  • 2018
    Title RIPK1 and Caspase-8 Ensure Chromosome Stability Independently of Their Role in Cell Death and Inflammation
    DOI 10.1016/j.molcel.2018.11.010
    Type Journal Article
    Author Liccardi G
    Journal Molecular Cell
    Link Publication
  • 2018
    Title STAC proteins associate to the IQ domain of CaV1.2 and inhibit calcium-dependent inactivation
    DOI 10.1073/pnas.1715997115
    Type Journal Article
    Author Campiglio M
    Journal Proceedings of the National Academy of Sciences
    Pages 1376-1381
    Link Publication
  • 2018
    Title Differential effects of Vav-promoter-driven overexpression of BCLX and BFL1 on lymphocyte survival and B cell lymphomagenesis
    DOI 10.1111/febs.14426
    Type Journal Article
    Author Tuzlak S
    Journal The FEBS Journal
    Pages 1403-1418
    Link Publication
  • 2018
    Title Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution
    DOI 10.1038/s41467-017-02424-0
    Type Journal Article
    Author Efremova M
    Journal Nature Communications
    Pages 32
    Link Publication
  • 2015
    Title miR-22 and miR-29a Are Members of the Androgen Receptor Cistrome Modulating LAMC1 and Mcl-1 in Prostate Cancer
    DOI 10.1210/me.2014-1358
    Type Journal Article
    Author Pasqualini L
    Journal Molecular Endocrinology
    Pages 1037-1054
    Link Publication
  • 2014
    Title Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells
    DOI 10.1186/1471-2407-14-52
    Type Journal Article
    Author Demir U
    Journal BMC Cancer
    Pages 52
    Link Publication
  • 2014
    Title Protein kinase C?: the pleiotropic T-cell signalling intermediate.
    DOI 10.1042/bst20140179
    Type Journal Article
    Author Wachowicz K
    Journal Biochemical Society transactions
    Pages 1512-8
  • 2014
    Title SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer
    DOI 10.1530/erc-13-0446
    Type Journal Article
    Author Hoefer J
    Journal Endocrine-Related Cancer
    Pages 175-187
    Link Publication
  • 2014
    Title Murine Langerin+ dermal dendritic cells prime CD8+ T cells while Langerhans cells induce cross-tolerance
    DOI 10.15252/emmm.201303283
    Type Journal Article
    Author Flacher V
    Journal EMBO Molecular Medicine
    Pages 1191-1204
    Link Publication
  • 2014
    Title Statin-induced depletion of geranylgeranyl pyrophosphate inhibits cell proliferation by a novel pathway of Skp2 degradation
    DOI 10.18632/oncotarget.3068
    Type Journal Article
    Author Vosper J
    Journal Oncotarget
    Pages 2889-2902
    Link Publication
  • 2014
    Title Differential Neuronal Targeting of a New and Two Known Calcium Channel ß4 Subunit Splice Variants Correlates with Their Regulation of Gene Expression
    DOI 10.1523/jneurosci.3935-13.2014
    Type Journal Article
    Author Etemad S
    Journal The Journal of Neuroscience
    Pages 1446-1461
    Link Publication
  • 2014
    Title Protein Kinase C ? Regulates the Phenotype of Murine CD4+ Th17 Cells
    DOI 10.1371/journal.pone.0096401
    Type Journal Article
    Author Wachowicz K
    Journal PLoS ONE
    Link Publication
  • 2014
    Title EpCAM is overexpressed in local and metastatic prostate cancer, suppressed by chemotherapy and modulated by MET-associated miRNA-200c/205
    DOI 10.1038/bjc.2014.366
    Type Journal Article
    Author Massoner P
    Journal British Journal of Cancer
    Pages 955-964
    Link Publication
  • 2014
    Title PIAS1 is a crucial factor for prostate cancer cell survival and a valid target in docetaxel resistant cells
    DOI 10.18632/oncotarget.2658
    Type Journal Article
    Author Puhr M
    Journal Oncotarget
    Pages 12043-12056
    Link Publication
  • 2014
    Title The late endosomal p14–MP1 (LAMTOR2/3) complex regulates focal adhesion dynamics during cell migration
    DOI 10.1083/jcb.201310043
    Type Journal Article
    Author Schiefermeier N
    Journal Journal of Cell Biology
    Pages 525-540
    Link Publication
  • 2019
    Title TET enzymes control antibody production and shape the mutational landscape in germinal centre B cells
    DOI 10.1111/febs.14934
    Type Journal Article
    Author Schoeler K
    Journal The FEBS Journal
    Pages 3566-3581
    Link Publication
  • 2019
    Title CHK1 dosage in germinal center B cells controls humoral immunity
    DOI 10.1038/s41418-019-0318-5
    Type Journal Article
    Author Schoeler K
    Journal Cell Death & Differentiation
    Pages 2551-2567
    Link Publication
  • 2014
    Title A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury
    DOI 10.1186/1478-811x-12-6
    Type Journal Article
    Author Ashraf M
    Journal Cell Communication and Signaling
    Pages 6
    Link Publication
  • 2013
    Title Novel therapeutic approaches for the treatment of castration-resistant prostate cancer
    DOI 10.1016/j.jsbmb.2013.06.002
    Type Journal Article
    Author Heidegger I
    Journal The Journal of Steroid Biochemistry and Molecular Biology
    Pages 248-256
    Link Publication
  • 2013
    Title The Kinase PKCa Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses
    DOI 10.1016/j.immuni.2012.09.021
    Type Journal Article
    Author Meisel M
    Journal Immunity
    Pages 41-52
    Link Publication
  • 2013
    Title Cbl-b mediates TGFß sensitivity by downregulating inhibitory SMAD7 in primary T cells
    DOI 10.1093/jmcb/mjt017
    Type Journal Article
    Author Gruber T
    Journal Journal of Molecular Cell Biology
    Pages 358-368
    Link Publication
  • 2013
    Title Death of p53-defective cells triggered by forced mitotic entry in the presence of DNA damage is not uniquely dependent on Caspase-2 or the PIDDosome
    DOI 10.1038/cddis.2013.470
    Type Journal Article
    Author Manzl C
    Journal Cell Death & Disease
    Link Publication
  • 2013
    Title A survey of tools for variant analysis of next-generation genome sequencing data
    DOI 10.1093/bib/bbs086
    Type Journal Article
    Author Pabinger S
    Journal Briefings in Bioinformatics
    Pages 256-278
    Link Publication
  • 2013
    Title Lapatinib and doxorubicin enhance the Stat1-dependent antitumor immune response
    DOI 10.1002/eji.201242505
    Type Journal Article
    Author Hannesdóttir L
    Journal European Journal of Immunology
    Pages 2718-2729
    Link Publication
  • 2013
    Title Microvillus Inclusion Disease: Loss of Myosin Vb Disrupts Intracellular Traffic and Cell Polarity
    DOI 10.1111/tra.12131
    Type Journal Article
    Author Thoeni C
    Journal Traffic
    Pages 22-42
  • 2013
    Title Possible pitfalls investigating cell death responses in genetically engineered mouse models and derived cell lines
    DOI 10.1016/j.ymeth.2013.02.012
    Type Journal Article
    Author Manzl C
    Journal Methods
    Pages 130-137
    Link Publication
  • 2013
    Title IL6 sensitizes prostate cancer to the antiproliferative effect of IFNa2 through IRF9
    DOI 10.1530/erc-13-0222
    Type Journal Article
    Author Erb H
    Journal Endocrine-Related Cancer
    Pages 677-689
    Link Publication
  • 2013
    Title Isolation of a Novel Thioflavin S–Derived Compound That Inhibits BAG-1–Mediated Protein Interactions and Targets BRAF Inhibitor–Resistant Cell Lines
    DOI 10.1158/1535-7163.mct-13-0142
    Type Journal Article
    Author Enthammer M
    Journal Molecular Cancer Therapeutics
    Pages 2400-2414
    Link Publication
  • 2013
    Title RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins
    DOI 10.1016/j.yexcr.2013.07.029
    Type Journal Article
    Author Koziel K
    Journal Experimental Cell Research
    Pages 2728-2738
    Link Publication
  • 2013
    Title Is real-time PCR the correct method to evaluate the incidence of human papillomavirus in prepuces of asymptomatic boys and men?
    DOI 10.1007/s00345-013-1190-4
    Type Journal Article
    Author Heidegger I
    Journal World Journal of Urology
    Pages 1199-1204
  • 2013
    Title Loss of membranous expression of the intracellular domain of EpCAM is a frequent event and predicts poor survival in patients with pancreatic cancer
    DOI 10.1111/his.12307
    Type Journal Article
    Author Fong D
    Journal Histopathology
    Pages 683-692
  • 2013
    Title PKC?/ß and CYLD Are Antagonistic Partners in the NF?B and NFAT Transactivation Pathways in Primary Mouse CD3+ T Lymphocytes
    DOI 10.1371/journal.pone.0053709
    Type Journal Article
    Author Thuille N
    Journal PLoS ONE
    Link Publication
  • 2013
    Title EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
    DOI 10.1186/1476-4598-12-56
    Type Journal Article
    Author Martowicz A
    Journal Molecular Cancer
    Pages 56
    Link Publication
  • 2013
    Title Quantitative measurement of the androgen receptor in prepuces of boys with and without hypospadias
    DOI 10.1111/j.1464-410x.2012.11731.x
    Type Journal Article
    Author Pichler R
    Journal BJU International
    Pages 265-270
  • 2013
    Title Increased leukocyte survival and accelerated onset of lymphoma in the absence of MCL-1 S159-phosphorylation
    DOI 10.1038/onc.2013.469
    Type Journal Article
    Author Lindner S
    Journal Oncogene
    Pages 5221-5224
    Link Publication
  • 2013
    Title Anterior gradient 2 and 3 – two prototype androgen-responsive genes transcriptionally upregulated by androgens and by oestrogens in prostate cancer cells
    DOI 10.1111/febs.12118
    Type Journal Article
    Author Bu H
    Journal The FEBS Journal
    Pages 1249-1266
    Link Publication
  • 2016
    Title MYC selects against reduced BCL2A1/A1 protein expression during B cell lymphomagenesis
    DOI 10.1038/onc.2016.362
    Type Journal Article
    Author Sochalska M
    Journal Oncogene
    Pages 2066-2073
    Link Publication
  • 2016
    Title ESCRT-III drives the final stages of CUPS maturation for unconventional protein secretion
    DOI 10.7554/elife.16299
    Type Journal Article
    Author Curwin A
    Journal eLife
    Link Publication
  • 2016
    Title ESCRT-III and Vps4: a dynamic multipurpose tool for membrane budding and scission
    DOI 10.1111/febs.13688
    Type Journal Article
    Author Adell M
    Journal The FEBS Journal
    Pages 3288-3302
    Link Publication
  • 2016
    Title The AR/NCOA1 axis regulates prostate cancer migration by involvement of PRKD1
    DOI 10.1530/erc-16-0160
    Type Journal Article
    Author Luef B
    Journal Endocrine-Related Cancer
    Pages 495-508
    Link Publication
  • 2016
    Title Novel Insights into the PKCß-dependent Regulation of the Oxidoreductase p66Shc*
    DOI 10.1074/jbc.m116.752766
    Type Journal Article
    Author Haller M
    Journal Journal of Biological Chemistry
    Pages 23557-23568
    Link Publication
  • 2016
    Title Cav1.3 (CACNA1D) L-type Ca2+ channel dysfunction in CNS disorders
    DOI 10.1113/jp270672
    Type Journal Article
    Author Pinggera A
    Journal The Journal of Physiology
    Pages 5839-5849
    Link Publication
  • 2016
    Title Voltage-gated calcium channels – from basic mechanisms to disease
    DOI 10.1113/jp272619
    Type Journal Article
    Author Striessnig J
    Journal The Journal of Physiology
    Pages 5817-5821
    Link Publication
  • 2016
    Title Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling
    DOI 10.1128/mcb.00999-15
    Type Journal Article
    Author Sakamoto K
    Journal Molecular and Cellular Biology
    Pages 1673-1690
    Link Publication
  • 2016
    Title Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy
    DOI 10.1016/j.imlet.2016.03.007
    Type Journal Article
    Author Klepsch V
    Journal Immunology Letters
    Pages 31-36
    Link Publication
  • 2016
    Title Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology
    DOI 10.1038/srep34528
    Type Journal Article
    Author Stanika R
    Journal Scientific Reports
    Pages 34528
    Link Publication
  • 2016
    Title Two distinct voltage-sensing domains control voltage sensitivity and kinetics of current activation in CaV1.1 calcium channels
    DOI 10.1085/jgp.201611568
    Type Journal Article
    Author Tuluc P
    Journal Journal of General Physiology
    Pages 437-449
    Link Publication
  • 2016
    Title Interrogating the relevance of mitochondrial apoptosis for vertebrate development and postnatal tissue homeostasis
    DOI 10.1101/gad.289298.116
    Type Journal Article
    Author Tuzlak S
    Journal Genes & Development
    Pages 2133-2151
    Link Publication
  • 2020
    Title PIDDosome-induced p53-dependent ploidy restriction facilitates hepatocarcinogenesis
    DOI 10.15252/embr.202050893
    Type Journal Article
    Author Sladky V
    Journal The EMBO Reports
    Link Publication
  • 2020
    Title A homozygous missense variant in CACNB4 encoding the auxiliary calcium channel beta4 subunit causes a severe neurodevelopmental disorder and impairs channel and non-channel functions
    DOI 10.1371/journal.pgen.1008625
    Type Journal Article
    Author De Bagneaux P
    Journal PLOS Genetics
    Link Publication
  • 2020
    Title Biophysical classification of a CACNA1D de novo mutation as a high-risk mutation for a severe neurodevelopmental disorder
    DOI 10.1186/s13229-019-0310-4
    Type Journal Article
    Author Hofer N
    Journal Molecular Autism
    Pages 4
    Link Publication
  • 2021
    Title Skin dendritic cells in melanoma are key for successful checkpoint blockade therapy
    DOI 10.1136/jitc-2020-000832
    Type Journal Article
    Author Prokopi A
    Journal Journal for ImmunoTherapy of Cancer
    Link Publication
  • 2015
    Title Knockdown of the Antiapoptotic Bcl-2 Family Member A1/Bfl-1 Protects Mice from Anaphylaxis
    DOI 10.4049/jimmunol.1400637
    Type Journal Article
    Author Ottina E
    Journal The Journal of Immunology
    Pages 1316-1322
    Link Publication
  • 2015
    Title Combined loss of the BH3-only proteins Bim and Bmf restores B-cell development and function in TACI-Ig transgenic mice
    DOI 10.1038/cdd.2015.8
    Type Journal Article
    Author Woess C
    Journal Cell Death & Differentiation
    Pages 1477-1488
    Link Publication
  • 2015
    Title The Aplidin analogs PM01215 and PM02781 inhibit angiogenesis in vitro and in vivo
    DOI 10.1186/s12885-015-1729-4
    Type Journal Article
    Author Borjan B
    Journal BMC Cancer
    Pages 738
    Link Publication
  • 2015
    Title Cell-type-specific tuning of Cav1.3 Ca2+-channels by a C-terminal automodulatory domain
    DOI 10.3389/fncel.2015.00309
    Type Journal Article
    Author Scharinger A
    Journal Frontiers in Cellular Neuroscience
    Pages 309
    Link Publication
  • 2015
    Title MAP3K11 is a tumor suppressor targeted by the oncomiR miR-125b in early B cells
    DOI 10.1038/cdd.2015.87
    Type Journal Article
    Author Knackmuss U
    Journal Cell Death & Differentiation
    Pages 242-252
    Link Publication
  • 2015
    Title A novel role for the histone acetyltransferase Hat1 in the CENP-A/CID assembly pathway in Drosophila melanogaster
    DOI 10.1093/nar/gkv1235
    Type Journal Article
    Author Boltengagen M
    Journal Nucleic Acids Research
    Pages 2145-2159
    Link Publication
  • 2015
    Title The insulin-like growth factor (IGF) axis as an anticancer target in prostate cancer
    DOI 10.1016/j.canlet.2015.07.026
    Type Journal Article
    Author Heidegger I
    Journal Cancer Letters
    Pages 113-121
  • 2015
    Title The tumor-modulatory effects of Caspase-2 and Pidd1 do not require the scaffold protein Raidd
    DOI 10.1038/cdd.2015.31
    Type Journal Article
    Author Peintner L
    Journal Cell Death & Differentiation
    Pages 1803-1811
    Link Publication
  • 2015
    Title The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance
    DOI 10.1016/j.celrep.2015.08.035
    Type Journal Article
    Author Hermann-Kleiter N
    Journal Cell Reports
    Pages 2072-2085
    Link Publication
  • 2015
    Title Impaired gp100-Specific CD8+ T-Cell Responses in the Presence of Myeloid-Derived Suppressor Cells in a Spontaneous Mouse Melanoma Model
    DOI 10.1038/jid.2015.241
    Type Journal Article
    Author Mairhofer D
    Journal Journal of Investigative Dermatology
    Pages 2785-2793
    Link Publication
  • 2015
    Title How is SR calcium release in muscle modulated by PIP(4,5)2?
    DOI 10.1085/jgp.201511395
    Type Journal Article
    Author Flucher B
    Journal Journal of General Physiology
    Pages 361-364
    Link Publication
  • 2015
    Title Both IGF1R and INSR Knockdown Exert Antitumorigenic Effects in Prostate Cancer In Vitro and In Vivo
    DOI 10.1210/me.2015-1073
    Type Journal Article
    Author Ofer P
    Journal Molecular Endocrinology
    Pages 1694-1707
    Link Publication
  • 2015
    Title Putative Prostate Cancer Risk SNP in an Androgen Receptor-Binding Site of the Melanophilin Gene Illustrates Enrichment of Risk SNPs in Androgen Receptor Target Sites
    DOI 10.1002/humu.22909
    Type Journal Article
    Author Bu H
    Journal Human Mutation
    Pages 52-64
    Link Publication
  • 2015
    Title Expression of the vault RNA protects cells from undergoing apoptosis
    DOI 10.1038/ncomms8030
    Type Journal Article
    Author Amort M
    Journal Nature Communications
    Pages 7030
    Link Publication
  • 2015
    Title A Polybasic Plasma Membrane Binding Motif in the I-II Linker Stabilizes Voltage-gated CaV1.2 Calcium Channel Function*
    DOI 10.1074/jbc.m115.645671
    Type Journal Article
    Author Kaur G
    Journal Journal of Biological Chemistry
    Pages 21086-21100
    Link Publication
  • 2015
    Title Physiological and Pharmacological Modulation of the Embryonic Skeletal Muscle Calcium Channel Splice Variant CaV1.1e
    DOI 10.1016/j.bpj.2015.01.026
    Type Journal Article
    Author Benedetti B
    Journal Biophysical Journal
    Pages 1072-1080
    Link Publication
  • 2015
    Title Conditional knockdown of BCL2A1 reveals rate-limiting roles in BCR-dependent B-cell survival
    DOI 10.1038/cdd.2015.130
    Type Journal Article
    Author Sochalska M
    Journal Cell Death & Differentiation
    Pages 628-639
    Link Publication
  • 2015
    Title The Role of Auxiliary Subunits for the Functional Diversity of Voltage-Gated Calcium Channels
    DOI 10.1002/jcp.24998
    Type Journal Article
    Author Campiglio M
    Journal Journal of Cellular Physiology
    Pages 2019-2031
    Link Publication
  • 2015
    Title The BH3-only protein Bad is dispensable for TNF-mediated cell death
    DOI 10.1038/cddis.2014.575
    Type Journal Article
    Author Ottina E
    Journal Cell Death & Disease
    Link Publication
  • 2015
    Title Soluble EpCAM levels in ascites correlate with positive cytology and neutralize catumaxomab activity in vitro
    DOI 10.1186/s12885-015-1371-1
    Type Journal Article
    Author Seeber A
    Journal BMC Cancer
    Pages 372
    Link Publication
  • 2015
    Title The coordinated action of the MVB pathway and autophagy ensures cell survival during starvation
    DOI 10.7554/elife.07736
    Type Journal Article
    Author Müller M
    Journal eLife
    Link Publication
  • 2021
    Title Alternative splicing of auxiliary ß2-subunits stabilizes Cav2.3 Ca2+ channel activity in continuously active midbrain dopamine neurons
    DOI 10.1101/2021.02.10.430224
    Type Preprint
    Author Siller A
    Pages 2021.02.10.430224
    Link Publication
  • 2021
    Title Stimulation of c-Jun/AP-1-Activity by the Cell Cycle Inhibitor p57Kip2
    DOI 10.3389/fcell.2021.664609
    Type Journal Article
    Author Kullmann M
    Journal Frontiers in Cell and Developmental Biology
    Pages 664609
    Link Publication
  • 2017
    Title The PIDDosome activates p53 in response to supernumerary centrosomes
    DOI 10.1101/gad.289728.116
    Type Journal Article
    Author Fava L
    Journal Genes & Development
    Pages 34-45
    Link Publication
  • 2017
    Title Pan-cancer Immunogenomic Analyses Reveal Genotype-Immunophenotype Relationships and Predictors of Response to Checkpoint Blockade
    DOI 10.1016/j.celrep.2016.12.019
    Type Journal Article
    Author Charoentong P
    Journal Cell Reports
    Pages 248-262
    Link Publication
  • 2017
    Title TIminer: NGS data mining pipeline for cancer immunology and immunotherapy
    DOI 10.1093/bioinformatics/btx377
    Type Journal Article
    Author Tappeiner E
    Journal Bioinformatics
    Pages 3140-3141
    Link Publication
  • 2017
    Title Cblb -deficient T cells are less susceptible to PD-L1-mediated inhibition
    DOI 10.18632/oncotarget.18360
    Type Journal Article
    Author Peer S
    Journal Oncotarget
    Pages 41841-41853
    Link Publication
  • 2017
    Title Stapled Voltage-Gated Calcium Channel (CaV) a-Interaction Domain (AID) Peptides Act As Selective Protein–Protein Interaction Inhibitors of CaV Function
    DOI 10.1021/acschemneuro.6b00454
    Type Journal Article
    Author Findeisen F
    Journal ACS Chemical Neuroscience
    Pages 1313-1326
    Link Publication
  • 2017
    Title Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma
    DOI 10.18632/oncotarget.17353
    Type Journal Article
    Author Steiner N
    Journal Oncotarget
    Pages 56243-56254
    Link Publication
  • 2017
    Title How and why are calcium currents curtailed in the skeletal muscle voltage-gated calcium channels?
    DOI 10.1113/jp273423
    Type Journal Article
    Author Flucher B
    Journal The Journal of Physiology
    Pages 1451-1463
    Link Publication
  • 2016
    Title Correction: Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
    DOI 10.1085/jgp.20161166309142016c
    Type Journal Article
    Author Flucher B
    Journal Journal of General Physiology
    Pages 357-357
    Link Publication
  • 2016
    Title Specific contributions of the four voltage-sensing domains in L-type calcium channels to gating and modulation
    DOI 10.1085/jgp.201611663
    Type Journal Article
    Author Flucher B
    Journal Journal of General Physiology
    Pages 91-95
    Link Publication
  • 2016
    Title Restricting calcium currents is required for correct fiber type specification in skeletal muscle
    DOI 10.1242/dev.129676
    Type Journal Article
    Author Sultana N
    Journal Development
    Pages 1547-1559
    Link Publication
  • 2016
    Title Retrograde Coupling: Muscle’s Orphan Signaling Pathway?
    DOI 10.1016/j.bpj.2015.12.032
    Type Journal Article
    Author Flucher B
    Journal Biophysical Journal
    Pages 870-871
    Link Publication
  • 2016
    Title cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation
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    Title SOCS3 Modulates the Response to Enzalutamide and Is Regulated by Androgen Receptor Signaling and CpG Methylation in Prostate Cancer Cells
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    Title Nuclear receptor NR2F6 inhibition potentiates responses to PD-L1/PD-1 cancer immune checkpoint blockade
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    Title STAC3 incorporation into skeletal muscle triads occurs independent of the dihydropyridine receptor
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    Title The BCL-2 pro-survival protein A1 is dispensable for T cell homeostasis on viral infection
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    Title Loss of a2d-1 Calcium Channel Subunit Function Increases the Susceptibility for Diabetes
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    Title STAC3 stably interacts through its C1 domain with CaV1.1 in skeletal muscle triads
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    Title New gain-of-function mutation shows CACNA1D as recurrently mutated gene in autism spectrum disorders and epilepsy
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    Title Neoantigens Generated by Individual Mutations and Their Role in Cancer Immunity and Immunotherapy
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    Title Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21
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    Title A1/Bfl-1 in leukocyte development and cell death
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    Title P53-induced protein with a death domain (PIDD): master of puppets?
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    Title Cav1.3 L-type Ca2+ channels mediate long-term adaptation in dopamine D2L-mediated GluA1 trafficking in the dorsal striatum following cocaine exposure
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    Title Defective cell death signalling along the Bcl-2 regulated apoptosis pathway compromises Treg cell development and limits their functionality in mice
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    Title Human chromokinesins promote chromosome congression and spindle microtubule dynamics during mitosis
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    Title Bioinformatics for cancer immunology and immunotherapy
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    Title Cyclin-Dependent Kinase 16/PCTAIRE Kinase 1 Is Activated by Cyclin Y and Is Essential for Spermatogenesis
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    Title Sorafenib decreases proliferation and induces apoptosis of prostate cancer cells by inhibition of the androgen receptor and Akt signaling pathways
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    Title Molecular analysis of neutrophil spontaneous apoptosis reveals a strong role for the pro-apoptotic BH3-only protein Noxa
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    Title Coronin 1A is an essential regulator of the TGFß receptor/SMAD3 signaling pathway in Th17 CD4+ T cells
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    Title Interleukin-6: A multifunctional targetable cytokine in human prostate cancer
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    Title Distinct expression patterns of dickkopf genes during late embryonic development of Danio rerio
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    Title Glucocorticoid-induced alterations in mitochondrial membrane properties and respiration in childhood acute lymphoblastic leukemia
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    Title STAT of the union: Dynamics of distinct tumor-associated macrophage subsets governed by STAT1
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    Title Development of a Multipurpose GATEWAY-Based Lentiviral Tetracycline-Regulated Conditional RNAi System (GLTR)
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    Title C-Terminal Modulatory Domain Controls Coupling of Voltage-Sensing to Pore Opening in Cav1.3 L-type Ca2+ Channels
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    Title CACNA1D De Novo Mutations in Autism Spectrum Disorders Activate Cav1.3 L-Type Calcium Channels
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    Title High STAT1 mRNA levels but not its tyrosine phosphorylation are associated with macrophage infiltration and bad prognosis in breast cancer
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    Title Pyrimidine-2,4,6-triones are a new class of voltage-gated L-type Ca2+ channel activators
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    Title A hormone-dependent feedback-loop controls androgen receptor levels by limiting MID1, a novel translation enhancer and promoter of oncogenic signaling
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    Title Replenishment of the B cell compartment after doxorubicin-induced hematopoietic toxicity is facilitated by STAT1
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    Title Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease
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    Title The synthetic glucocorticoids prednisolone and dexamethasone regulate the same genes in acute lymphoblastic leukemia cells
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    Title L-type Ca2+ channels in heart and brain
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    Title Oncogenic functions of IGF1R and INSR in prostate cancer include enhanced tumor growth, cell migration and angiogenesis
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    Title The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells
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    Title Coordinated binding of Vps4 to ESCRT-III drives membrane neck constriction during MVB vesicle formation
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    Title PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors
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    Title Deregulated cell death and lymphocyte homeostasis cause premature lethality in mice lacking the BH3-only proteins Bim and Bmf
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    Title The juvenile myoclonic epilepsy mutant of the calcium channel ß4 subunit displays normal nuclear targeting in nerve and muscle cells
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    Title In situ proliferation contributes to accumulation of tumor-associated macrophages in spontaneous mammary tumors
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    Title Anatomical distribution analysis reveals lack of Langerin+ dermal dendritic cells in footpads and tail of C57BL/6 mice
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    Title Adoptive Transfer of siRNA Cblb-Silenced CD8+ T Lymphocytes Augments Tumor Vaccine Efficacy in a B16 Melanoma Model
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    Title Targeting antiapoptotic A1/Bfl-1 by in vivo RNAi reveals multiple roles in leukocyte development in mice
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    Title Phenotype-dependent effects of EpCAM expression on growth and invasion of human breast cancer cell lines
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    Title Haematopoietic stem cell survival and transplantation efficacy is limited by the BH3-only proteins Bim and Bmf
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    Title Protein Kinase C Inhibition Ameliorates Posttransplantation Preservation Injury in Rat Renal Transplants
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    Title Epithelial-to-Mesenchymal Transition Leads to Docetaxel Resistance in Prostate Cancer and Is Mediated by Reduced Expression of miR-200c and miR-205
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    Title PIAS1 Is Increased in Human Prostate Cancer and Enhances Proliferation through Inhibition of p21
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    Title MMTV-neu mice deficient in STAT1 are susceptible to develop ovarian teratomas
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    Title Diverse Functions of IGF/Insulin Signaling in Malignant and Noncancerous Prostate Cells: Proliferation in Cancer Cells and Differentiation in Noncancerous Cells
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    Title Membrane Abscission: First Glimpse at Dynamic ESCRTs
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    Title Minor cell-death defects but reduced tumor latency in mice lacking the BH3-only proteins Bad and Bmf
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    Title Lamin A/C protein is overexpressed in tissue-invading prostate cancer and promotes prostate cancer cell growth, migration and invasion through the PI3K/AKT/PTEN pathway
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    Title Research Resource: Transcriptional Response to Glucocorticoids in Childhood Acute Lymphoblastic Leukemia
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    Title Mitochondrial ROS production under cellular stress: comparison of different detection methods
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    Title Essential Role of E3 Ubiquitin Ligase Activity in Cbl-b–Regulated T Cell Functions
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    Title Generation and Evaluation of an IPTG-Regulated Version of Vav-Gene Promoter for Mouse Transgenesis
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    Title Inhibition of the Acetyltransferases p300 and CBP Reveals a Targetable Function for p300 in the Survival and Invasion Pathways of Prostate Cancer Cell Lines
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    Title Comprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice
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    Title Effects of EpCAM overexpression on human breast cancer cell lines
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    Title Soluble gp130 Regulates Prostate Cancer Invasion and Progression in an Interleukin-6 Dependent and Independent Manner
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    Title PKCa and PKCß cooperate functionally in CD3-induced de novo IL-2 mRNA transcription
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    Title Stability of the Endosomal Scaffold Protein LAMTOR3 Depends on Heterodimer Assembly and Proteasomal Degradation*
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    Title [-2]proPSA is an early marker for prostate cancer aggressiveness
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    Title Guarding effector T-cell survival: all for one, Mcl-1 for all?
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    Title Spindly/CCDC99 Is Required for Efficient Chromosome Congression and Mitotic Checkpoint Regulation
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    Title The anterior gradient 2 (AGR2) gene is overexpressed in prostate cancer and may be useful as a urine sediment marker for prostate cancer detection
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    Title PLZF/ZBTB16, a glucocorticoid response gene in acute lymphoblastic leukemia, interferes with glucocorticoid-induced apoptosis
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    Title Expression, regulation and function of phosphofructo-kinase/fructose-biphosphatases (PFKFBs) in glucocorticoid-induced apoptosis of acute lymphoblastic leukemia cells
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    Title Non–Ca2+-conducting Ca2+ channels in fish skeletal muscle excitation-contraction coupling
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    Title Reciprocal Interactions Regulate Targeting of Calcium Channel ß Subunits and Membrane Expression of a1 Subunits in Cultured Hippocampal Neurons*
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    Title Activity and calcium regulate nuclear targeting of the calcium channel beta4b subunit in nerve and muscle cells
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    Title Infiltrating CD11b+CD11c+ cells have the potential to mediate inducible nitric oxide synthase-dependent cell death in mammary carcinomas of HER-2/neu transgenic mice
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    Title Bcl2 family proteins in carcinogenesis and the treatment of cancer
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    Title Functional analyses of Src-like adaptor (SLA), a glucocorticoid-regulated gene in acute lymphoblastic leukemia
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    Title Loss of RAF kinase inhibitor protein is a somatic event in the pathogenesis of therapy-related acute myeloid leukemias with C-RAF germline mutations
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    Journal Leukemia
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    Title Down-regulation of Suppressor of Cytokine Signaling-3 Causes Prostate Cancer Cell Death through Activation of the Extrinsic and Intrinsic Apoptosis Pathways
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    Title C. E. Alken Preis 2007: Androgene stimulieren die Expression von SOCS-3 und bewirken die Inhibition der Proliferation und Sekretion
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    Title PKC-? Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation
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    Title Suppressor of Cytokine Signaling (SOCS)-1 Is Expressed in Human Prostate Cancer and Exerts Growth-Inhibitory Function through Down-Regulation of Cyclins and Cyclin-Dependent Kinases
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    Title TROP2 expression as prognostic marker for gastric carcinoma
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    Title Proper Restoration of Excitation-Contraction Coupling in the Dihydropyridine Receptor ß1-null Zebrafish Relaxed Is an Exclusive Function of the ß1a Subunit*
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    Title Oligomeric proanthocyanidin complexes (OPC) exert anti-proliferative and pro-apoptotic effects on prostate cancer cells
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    Journal The Prostate
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    Title Survival Signaling by C-RAF: Mitochondrial Reactive Oxygen Species and Ca2+ Are Critical Targets
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    Title Auxiliary Ca2+ channel subunits: lessons learned from muscle
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    Title Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy?
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    Title High expression of TROP2 correlates with poor prognosis in pancreatic cancer
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    Title PKC-? selectively controls the adhesion-stimulating molecule Rap1
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    Title Cytoplasmic signaling in the control of mitochondrial uproar?
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    Title Interaction and Functional Interference of Glucocorticoid Receptor and SOCS1*
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    Title Signaling through RAS-RAF-MEK-ERK: from basics to bedside.
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    Title Expression of the IGF Axis Is Decreased in Local Prostate Cancer but Enhanced after Benign Prostate Epithelial Differentiation and TGF-ß Treatment
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    Journal The American Journal of Pathology
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    Title IL-6 causes multiple effects in androgen-sensitive and -insensitive prostate cancer cell lines
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    Title Surface Traffic of Dendritic CaV1.2 Calcium Channels in Hippocampal Neurons
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    Title Bcl-2-regulated cell death signalling in the prevention of autoimmunity
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    Title Loss of Cav1.3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness
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    Journal Nature Neuroscience
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    Title Loss-of-function of MYO5B is the main cause of microvillus inclusion disease: 15 novel mutations and a CaCo-2 RNAi cell model
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    Title Skeletal muscle excitation–contraction coupling is independent of a conserved heptad repeat motif in the C-terminus of the DHPRß1a subunit
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    Title SOCS-3 antagonises the proliferative and migratory effects of fibroblast growth factor-2 in prostate cancer by inhibition of p44/p42 MAPK signalling
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    Title Cytokine disbalance in common human cancers
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    Title Lysosomal signaling in control of degradation pathways
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    Title The mammalian skeletal muscle DHPR has larger Ca2+ conductance and is phylogenetically ancient to the early ray-finned fish sterlet (Acipenser ruthenus)
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    Title Mechanistic rationale for MCL1 inhibition during androgen deprivation therapy
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    Title PIAS1 is a determinant of poor survival and acts as a positive feedback regulator of AR signaling through enhanced AR stabilization in prostate cancer
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    Title The colorectal cancer immune paradox revisited
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    Title L-type calcium channels as drug targets in CNS disorders
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    Title Lessons from gain- and loss-of-function models of pro-survival Bcl2 family proteins: implications for targeted therapy
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    Title The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland
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    Title SLC38A9 is a component of the lysosomal amino acid sensing machinery that controls mTORC1
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    Title Pharmacology of L-type Calcium Channels: Novel Drugs for Old Targets?
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    Title Characterization of the immunophenotypes and antigenomes of colorectal cancers reveals distinct tumor escape mechanisms and novel targets for immunotherapy
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    Title TROP2: a novel prognostic marker in squamous cell carcinoma of the oral cavity
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    Title Suppressor of cytokine signalling-3 is up-regulated by androgen in prostate cancer cell lines and inhibits androgen-mediated proliferation and secretion
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    Journal Endocrine-Related Cancer
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    Title Suppressor of Cytokine Signaling-3 Antagonizes cAMP Effects on Proliferation and Apoptosis and Is Expressed in Human Prostate Cancer
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    Journal The American Journal of Pathology
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