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Metabolic and Cardiovascular Disease

Metabolic and Cardiovascular Disease

Gerald Höfler (ORCID: 0000-0002-9056-3063)
  • Grant DOI 10.55776/W1226
  • Funding program Doctoral Programs
  • Status ended
  • Start July 1, 2010
  • End June 30, 2024
  • Funding amount € 9,922,437
  • Project website
  • E-mail

Disciplines

Biology (60%); Medical-Theoretical Sciences, Pharmacy (40%)

Keywords

    Lipid-Associated Disorders, Mouse And Cell Culture Models, Gene And Protein Regulation, Channel Function And Cation Handling, Cardiovascular Disease, Molecular Pathology

Abstract

The doctoral program "Metabolic and Cardiovascular Disease" (DK-MCD) is an educational program hosted by the Medical University of Graz, Austria. Fifteen researchers from three universities (Medical University of Graz, University of Graz, Graz University of Technology) have developed a multidisciplinary graduate training program to investigate the molecular mechanisms and cellular functions involved in the pathogenesis of metabolic and cardiovascular disease. The thematic diversity of the DK-MCD ensures broad exposure of the participating students to important issues in biomedicine. Research topics were selected to maximize exchange within the consortium concerning technical proficiency and advances in biomedical research. Importantly, the DK-MCD is sufficiently diverse to encourage students to look beyond the focus of their own research. To provide a stimulating and provocative research environment, the DK-MCD faculty was chosen for their excellence in research as indicated by publishing and funding records as well as their excellence in teaching. The faculty represents a well-balanced combination of established and junior scientists. Especially in the latter group female researchers have a prominent role. All DK-MCD faculty members are involved in local, national and international research networks. Thus, the DK-MCD will be embedded in an established inter-laboratory cooperation and communication environment. Faculty members contribute to this initiative by their scientific background in both basic research and clinical medicine. Their technical expertise is complemented by excellent infrastructure and state-of-the-art technology for biomedical research. The DK-MCD faculty is well experienced in training doctoral students. The biomedically-oriented DK-MCD curriculum complements the existing biotechnology-oriented DK-Plus "Molecular Enzymology". Therefore, our initiative fills an existing gap and covers essential educational aspects for life sciences not yet available in Graz. The DK-MCD provides a challenging PhD education program which is unique because it (i) comprises a multidisciplinary faculty from three local universities, (ii) requires (inter)national student exchange and (iii) covers major topics in metabolic and cardiovascular disease from basic research to clinical aspects in a translational approach. We are confident that the DK-MCD will attract highly motivated and dedicated students seeking knowledge and skills that will enable them to pursue careers in areas of growing importance for health and society.

Consortium
  • Dagmar Kratky, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Frank Madeo, Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Gerald Höfler, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Günter Hämmerle, Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Klaus Groschner, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Martin Pichler, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Peter Fickert, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Ruth Birner-Grünberger, Technische Universität Wien
    consortium member (01.07.2010 - 30.06.2024)
  • Tobias Madl, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
  • Wolfgang F. Graier, Medizinische Universität Graz
    consortium member (01.07.2010 - 30.06.2024)
Research institution(s)
  • Medizinische Universität Graz
  • Universität Graz
Project participants
  • Ronald Philip Kühnlein, Universität Graz , national collaboration partner
International project participants
  • Kerry-Anne Rye, University of New South Wales - Australia
  • Jason R. B. Dyck, University of Alberta - Canada
  • Jasminka Stefulj, Rudjer Boskovic Institute - Croatia
  • Leos Shivaya Valasek, Academy of Sciences of the Czech Republic - Czechia
  • Karsten Kristiansen, University of Copenhagen - Denmark
  • Matti Jauhiainen, Minerva Institute for Medical Research - Finland
  • Eric Honore, Centre National de la Recherche Scientifique - France
  • Sylvain Richard, Centre National de la Recherche Scientifique Montpellier - France
  • Guido Kroemer, INSERM U1138 - France
  • Jérôme Galon, Universite Pierre et Marie Curie - France
  • Wolfgang Linke, Westfälische Wilhelms-Universität - Germany
  • Stephan E. Lehnart, Universitätsmedizin Göttingen - Germany
  • Pavel Strnad, Universitätsklinikum Ulm - Germany
  • Klaus Pantel, Universitätsklinikum Hamburg-Eppendorf - Germany
  • Jörg Heeren, Universitätsklinikum Hamburg-Eppendorf - Germany
  • Alexandra K. Kiemer, Universität des Saarlandes - Germany
  • Christian Pott, Universität Münster - Germany
  • Jürgen Arnhold, Universität Leipzig - Germany
  • Elke Deuerling, Universität Konstanz - Germany
  • Stephan Baldus, Uniklinik Köln - Germany
  • Lars Maier, Universitätsmedizin Göttingen - Germany
  • Friedrich Lottspeich, Max-Planck-Gesellschaft - Germany
  • Hans R. Lehrach, Max Planck-Institut - Germany
  • Thomas Gudermann, Ludwig-Maximilians-Universität München - Germany
  • Thomas Cremer, Ludwig-Maximilians-Universität München - Germany
  • Karl Lenhard Rudolph, Leibniz Gemeinschaft - Germany
  • Gerd Hasenfuß, Georg-August-Universität Göttingen - Germany
  • Regine Heller, Friedrich Schiller Universität Jena - Germany
  • Markus Hecker, Ruprecht-Karls-Universität Heidelberg - Germany
  • Stephan Sigrist, Freie Universität Berlin - Germany
  • Holger Sültmann, Deutsches Krebsforschungszentrum Heidelberg - Germany
  • Ruggero De Maria, IRCCS Istituti Fisioterapici Ospitalieri - Italy
  • Claudio Luchinat, Università degli Studi di Firenze - Italy
  • Fabrizio DAdda Di Fagagna, IFOM Foundation - Italy
  • Atsumi Nitta, University of Toyama - Japan
  • Kaoru Goto, Yamagata University School of Medicine - Japan
  • Miranda Van Eck, Universiteit Leiden - Netherlands
  • Ulrich Schotten, Universiteit Maastricht - Netherlands
  • Albert K. Groen, University of Groningen - Netherlands
  • Albert J.R. Heck, Utrecht University - Netherlands
  • Montserrat Pinent Armengol, Universitat Rovira i Virgili - Spain
  • Jens Nielsen, Chalmers University of Technology - Sweden
  • Ingemar Björkhem, Karolinska University Hospital - Sweden
  • Hanns-Ulrich Marschall, University of Gothenburg - Sweden
  • Maud Frieden, Université de Genève - Switzerland
  • Birthe Fahrenkrog, Universität Basel - Switzerland
  • Johan Auwerx, École polytechnique fédérale de Lausanne - Switzerland
  • Nicolas Demaurex, University of Geneva Medical Center - Switzerland
  • Martin Kussmann, Nestlé Research Center - Switzerland
  • Bruno Stieger, University of Zurich - Switzerland
  • E. E. Kershaw, University of Pittsburgh Medical Center - USA
  • Hartmut W. Jaeschke, University of Kansas - USA
  • Donald M. Bers, University of California at Davis - USA
  • David D. Moore, University of California Berkeley - USA
  • Gyorgy Hajnoczky, Thomas Jefferson University - USA
  • Michael Xi Zhu, The University of Texas Health Science Center - USA
  • Vittorio Sebastiano, Stanford University School of Medicine - USA
  • Dawn L. Brasaemle, RUTGERS - The State University of New Jersey - USA
  • Robert J. Schneider, New York University Medical Center - USA
  • Jesse C. Hay, The University of Montana - USA
  • Indu S. Ambudkar, National Institutes of Health - USA
  • Snorri S. Thorgeirsson, National Cancer Institute / NIH - USA
  • Robert A. Roth, Michigan State University - USA
  • Robert V. Farese, Memorial Sloan Kettering Cancer Center - USA
  • Matthew G. Vander Heiden, MIT - Massachusetts Institute of Technology - USA
  • John Quackenbush, Dana-Farber Cancer Institute - USA
  • Ira Jay Goldberg, Columbia University Medical Center - USA
  • Jeffery D. Molkentin, Cincinnati Children´s Medical Center - USA
  • Lutz Birnbaumer, National Institutes of Health - USA
  • Barbara Casadei, University of Oxford - United Kingdom
  • David A. Eisner, University of Manchester - United Kingdom
  • Peter J. Voshol, University of Cambridge - United Kingdom
  • Michael R. Duchen, University College London - United Kingdom
  • Francis Antony Lai, Cardiff University - United Kingdom
  • Ian P. M. Tomlinson, The University of Oxford - United Kingdom
  • Nigel Carter, Sanger Centre - United Kingdom
  • György Szabadkai, University College London - United Kingdom

Research Output

  • 29121 Citations
  • 594 Publications
Publications
  • 2016
    Title Chapter Nineteen Methods to Assess Autophagy and Chronological Aging in Yeast
    DOI 10.1016/bs.mie.2016.09.086
    Type Book Chapter
    Author Kainz K
    Publisher Elsevier
    Pages 367-394
  • 2016
    Title PpEst is a novel PBAT degrading polyesterase identified by proteomic screening of Pseudomonas pseudoalcaligenes
    DOI 10.1007/s00253-016-7992-8
    Type Journal Article
    Author Wallace P
    Journal Applied Microbiology and Biotechnology
    Pages 2291-2303
    Link Publication
  • 2016
    Title Lysosomal acid lipase regulates VLDL synthesis and insulin sensitivity in mice
    DOI 10.1007/s00125-016-3968-6
    Type Journal Article
    Author Radovic B
    Journal Diabetologia
    Pages 1743-1752
    Link Publication
  • 2016
    Title PRMT1-mediated methylation of MICU1 determines the UCP2/3 dependency of mitochondrial Ca2+ uptake in immortalized cells
    DOI 10.1038/ncomms12897
    Type Journal Article
    Author Madreiter-Sokolowski C
    Journal Nature Communications
    Pages 12897
    Link Publication
  • 2016
    Title Intact mitochondrial Ca2+ uniport is essential for agonist-induced activation of endothelial nitric oxide synthase (eNOS)
    DOI 10.1016/j.freeradbiomed.2016.11.049
    Type Journal Article
    Author Charoensin S
    Journal Free Radical Biology and Medicine
    Pages 248-259
    Link Publication
  • 2016
    Title Sequestosome 1/p62 Protein Is Associated with Autophagic Removal of Excess Hepatic Endoplasmic Reticulum in Mice*
    DOI 10.1074/jbc.m116.739821
    Type Journal Article
    Author Yang H
    Journal Journal of Biological Chemistry
    Pages 18663-18674
    Link Publication
  • 2016
    Title Development of novel FP-based probes for live-cell imaging of nitric oxide dynamics
    DOI 10.1038/ncomms10623
    Type Journal Article
    Author Eroglu E
    Journal Nature Communications
    Pages 10623
    Link Publication
  • 2016
    Title N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes
    DOI 10.1038/srep23723
    Type Journal Article
    Author Prokesch A
    Journal Scientific Reports
    Pages 23723
    Link Publication
  • 2016
    Title Sexually transmitted infections: old foes on the rise
    DOI 10.15698/mic2016.09.522
    Type Journal Article
    Author Carmona-Gutierrez D
    Journal Microbial Cell
    Pages 361
    Link Publication
  • 2016
    Title Critical role of the peroxisomal protein PEX16 in white adipocyte development and lipid homeostasis
    DOI 10.1016/j.bbalip.2016.12.009
    Type Journal Article
    Author Hofer D
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 358-368
    Link Publication
  • 2016
    Title Acyl-CoA:Diacylglycerol Acyltransferase 1 Expression Level in the Hematopoietic Compartment Impacts Inflammation in the Vascular Plaques of Atherosclerotic Mice
    DOI 10.1371/journal.pone.0156364
    Type Journal Article
    Author Vujic N
    Journal PLOS ONE
    Link Publication
  • 2016
    Title Recognition of the 3' splice site RNA by the U2AF heterodimer involves a dynamic population shift
    DOI 10.1073/pnas.1605873113
    Type Journal Article
    Author Voith Von Voithenberg L
    Journal Proceedings of the National Academy of Sciences
    Link Publication
  • 2016
    Title KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients
    DOI 10.18632/oncotarget.13224
    Type Journal Article
    Author Kammerer S
    Journal Oncotarget
    Pages 84705-84717
    Link Publication
  • 2016
    Title Whole-genome plasma sequencing reveals focal amplifications as a driving force in metastatic prostate cancer
    DOI 10.1038/ncomms12008
    Type Journal Article
    Author Ulz P
    Journal Nature Communications
    Pages 12008
    Link Publication
  • 2016
    Title Resveratrol Specifically Kills Cancer Cells by a Devastating Increase in the Ca2+ Coupling Between the Greatly Tethered Endoplasmic Reticulum and Mitochondria
    DOI 10.1159/000447844
    Type Journal Article
    Author Madreiter-Sokolowski C
    Journal Cellular Physiology and Biochemistry
    Pages 1404-1420
    Link Publication
  • 2016
    Title Fat in the heart: The enzymatic machinery regulating cardiac triacylglycerol metabolism
    DOI 10.1016/j.bbalip.2016.02.014
    Type Journal Article
    Author Heier C
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 1500-1512
  • 2016
    Title Autophagy: one more Nobel Prize for yeast
    DOI 10.15698/mic2016.12.544
    Type Journal Article
    Author Zimmermann A
    Journal Microbial Cell
    Pages 579
    Link Publication
  • 2015
    Title Mild hypothermia induces incomplete left ventricular relaxation despite spontaneous bradycardia in pigs
    DOI 10.1111/apha.12439
    Type Journal Article
    Author Schwarzl M
    Journal Acta Physiologica
    Pages 653-663
  • 2015
    Title The GPR 55 agonist, L-a-lysophosphatidylinositol, mediates ovarian carcinoma cell-induced angiogenesis
    DOI 10.1111/bph.13196
    Type Journal Article
    Author Hofmann N
    Journal British Journal of Pharmacology
    Pages 4107-4118
    Link Publication
  • 2015
    Title Piezo1 forms mechanosensitive ion channels in the human MCF-7 breast cancer cell line
    DOI 10.1038/srep08364
    Type Journal Article
    Author Li C
    Journal Scientific Reports
    Pages 8364
    Link Publication
  • 2014
    Title Nucleocytosolic Depletion of the Energy Metabolite Acetyl-Coenzyme A Stimulates Autophagy and Prolongs Lifespan
    DOI 10.1016/j.cmet.2014.02.010
    Type Journal Article
    Author Eisenberg T
    Journal Cell Metabolism
    Pages 431-444
    Link Publication
  • 2014
    Title MiR-200a regulates epithelial to mesenchymal transition-related gene expression and determines prognosis in colorectal cancer patients
    DOI 10.1038/bjc.2014.51
    Type Journal Article
    Author Pichler M
    Journal British Journal of Cancer
    Pages 1614-1621
    Link Publication
  • 2014
    Title A histone point mutation that switches on autophagy
    DOI 10.4161/auto.28767
    Type Journal Article
    Author Eisenberg T
    Journal Autophagy
    Pages 1143-1145
    Link Publication
  • 2014
    Title Spermidine protects against a-synuclein neurotoxicity
    DOI 10.4161/15384101.2014.973309
    Type Journal Article
    Author Büttner S
    Journal Cell Cycle
    Pages 3903-3908
    Link Publication
  • 2014
    Title Response to letter by Tsikas et al.
    DOI 10.1016/j.ijcard.2014.09.111
    Type Journal Article
    Author Koyani C
    Journal International Journal of Cardiology
    Pages 140-141
  • 2014
    Title Epigenetic Silencing of Apoptosis-Inducing Gene Expression Can Be Efficiently Overcome by Combined SAHA and TRAIL Treatment in Uterine Sarcoma Cells
    DOI 10.1371/journal.pone.0091558
    Type Journal Article
    Author Fröhlich L
    Journal PLoS ONE
    Link Publication
  • 2014
    Title Novel amino-ß-lactam derivatives as potent cholesterol absorption inhibitors
    DOI 10.1016/j.ejmech.2014.10.014
    Type Journal Article
    Author Dražic T
    Journal European Journal of Medicinal Chemistry
    Pages 722-734
    Link Publication
  • 2014
    Title TRPC3: A Multifunctional Signaling Molecule
    DOI 10.1007/978-3-642-54215-2_4
    Type Book Chapter
    Author Lichtenegger M
    Publisher Springer Nature
    Pages 67-84
  • 2014
    Title miR-206 controls LXRa expression and promotes LXR-mediated cholesterol efflux in macrophages
    DOI 10.1016/j.bbalip.2014.02.006
    Type Journal Article
    Author Vinod M
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 827-835
    Link Publication
  • 2014
    Title Understanding high-density lipoprotein function in disease: Recent advances in proteomics unravel the complexity of its composition and biology
    DOI 10.1016/j.plipres.2014.07.003
    Type Journal Article
    Author Birner-Gruenberger R
    Journal Progress in Lipid Research
    Pages 36-46
    Link Publication
  • 2014
    Title TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation
    DOI 10.1242/bio.20149571
    Type Journal Article
    Author Hofmann N
    Journal Biology Open
    Pages 1164-1172
    Link Publication
  • 2014
    Title Characterization of rat serum amyloid A4 (SAA4): A novel member of the SAA superfamily
    DOI 10.1016/j.bbrc.2014.07.054
    Type Journal Article
    Author Rossmann C
    Journal Biochemical and Biophysical Research Communications
    Pages 1643-1649
    Link Publication
  • 2014
    Title Role of adipose tissue in methionine–choline-deficient model of non-alcoholic steatohepatitis (NASH)
    DOI 10.1016/j.bbadis.2014.02.012
    Type Journal Article
    Author Jha P
    Journal Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
    Pages 959-970
    Link Publication
  • 2014
    Title Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia
    DOI 10.1002/hep.26732
    Type Journal Article
    Author Jha P
    Journal Hepatology
    Pages 858-869
    Link Publication
  • 2015
    Title Adipocyte SIRT1 knockout promotes PPAR? activity, adipogenesis and insulin sensitivity in chronic-HFD and obesity
    DOI 10.1016/j.molmet.2015.02.007
    Type Journal Article
    Author Mayoral R
    Journal Molecular Metabolism
    Pages 378-391
    Link Publication
  • 2015
    Title Generation of Red-Shifted Cameleons for Imaging Ca2+ Dynamics of the Endoplasmic Reticulum
    DOI 10.3390/s150613052
    Type Journal Article
    Author Waldeck-Weiermair M
    Journal Sensors
    Pages 13052-13068
    Link Publication
  • 2015
    Title A robust and simple protocol for the synthesis of arylfluorophosphonates
    DOI 10.1016/j.tetlet.2015.08.061
    Type Journal Article
    Author Leypold M
    Journal Tetrahedron Letters
    Pages 5619-5622
  • 2015
    Title Synergism of proteomics and mRNA sequencing for enzyme discovery
    DOI 10.1016/j.jbiotec.2015.12.015
    Type Journal Article
    Author Sturmberger L
    Journal Journal of Biotechnology
    Pages 132-138
    Link Publication
  • 2015
    Title Interference with distinct steps of sphingolipid synthesis and signaling attenuates proliferation of U87MG glioma cells
    DOI 10.1016/j.bcp.2015.05.007
    Type Journal Article
    Author Bernhart E
    Journal Biochemical Pharmacology
    Pages 119-130
    Link Publication
  • 2015
    Title Behavioral and molecular processing of visceral pain in the brain of mice: impact of colitis and psychological stress
    DOI 10.3389/fnbeh.2015.00177
    Type Journal Article
    Author Jain P
    Journal Frontiers in Behavioral Neuroscience
    Pages 177
    Link Publication
  • 2015
    Title Synthesis and evaluation of novel amide amino-ß-lactam derivatives as cholesterol absorption inhibitors
    DOI 10.1016/j.bmc.2015.03.067
    Type Journal Article
    Author Dražic T
    Journal Bioorganic & Medicinal Chemistry
    Pages 2353-2359
    Link Publication
  • 2015
    Title TRPC3 contributes to regulation of cardiac contractility and arrhythmogenesis by dynamic interaction with NCX1
    DOI 10.1093/cvr/cvv022
    Type Journal Article
    Author Doleschal B
    Journal Cardiovascular Research
    Pages 163-173
    Link Publication
  • 2015
    Title A porcine model of early atrial fibrillation using a custom-built, radio transmission-controlled pacemaker
    DOI 10.1016/j.jelectrocard.2015.12.012
    Type Journal Article
    Author Schwarzl M
    Journal Journal of Electrocardiology
    Pages 124-131
  • 2015
    Title Myeloperoxidase scavenges peroxynitrite: A novel anti-inflammatory action of the heme enzyme
    DOI 10.1016/j.abb.2015.02.028
    Type Journal Article
    Author Koyani C
    Journal Archives of Biochemistry and Biophysics
    Pages 1-9
    Link Publication
  • 2015
    Title A synonymous EGFR polymorphism predicting responsiveness to anti-EGFR therapy in metastatic colorectal cancer patients
    DOI 10.1007/s13277-015-4543-3
    Type Journal Article
    Author Bonin S
    Journal Tumor Biology
    Pages 7295-7303
  • 2015
    Title Low spinophilin expression enhances aggressive biological behavior of breast cancer
    DOI 10.18632/oncotarget.3586
    Type Journal Article
    Author Schwarzenbacher D
    Journal Oncotarget
    Pages 11191-11202
    Link Publication
  • 2015
    Title Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4
    DOI 10.1016/j.jhep.2015.04.030
    Type Journal Article
    Author Out C
    Journal Journal of Hepatology
    Pages 697-704
    Link Publication
  • 2015
    Title Neutrophil proteolytic activation cascades: a possible mechanistic link between chronic periodontitis and coronary heart disease
    DOI 10.1177/1753425915617521
    Type Journal Article
    Author Alfakry H
    Journal Innate Immunity
    Pages 85-99
    Link Publication
  • 2015
    Title Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
    DOI 10.1016/j.jhep.2014.12.034
    Type Journal Article
    Author Mueller M
    Journal Journal of Hepatology
    Pages 1398-1404
    Link Publication
  • 2015
    Title Non-invasive detection of genome-wide somatic copy number alterations by liquid biopsies
    DOI 10.1016/j.molonc.2015.12.004
    Type Journal Article
    Author Heitzer E
    Journal Molecular Oncology
    Pages 494-502
    Link Publication
  • 2016
    Title MiR-206 is expressed in pancreatic islets and regulates glucokinase activity
    DOI 10.1152/ajpendo.00510.2015
    Type Journal Article
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    Title a/ß-Hydrolase Domain Containing Protein 15 (ABHD15) – an Adipogenic Protein Protecting from Apoptosis
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    Title Istaroxime, a potential anticancer drug in prostate cancer, exerts beneficial functional effects in healthy and diseased human myocardium
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    Title Cleaning out the Litterbox of Proteomic Scientists’ Favorite Pet: Optimized Data Analysis Avoiding Trypsin Artifacts
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    Title Lysosomal Acid Lipase Hydrolyzes Retinyl Ester and Affects Retinoid Turnover*
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    Title 1-Oleyl-lysophosphatidic acid (LPA) promotes polarization of BV-2 and primary murine microglia towards an M1-like phenotype
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    Title Activation of the MAPK/Akt/Nrf2-Egr1/HO-1-GCLc axis protects MG-63 osteosarcoma cells against 15d-PGJ2-mediated cell death
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    Title Loss of adipose triglyceride lipase is associated with human cancer and induces mouse pulmonary neoplasia
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    Title Liver p53 is stabilized upon starvation and required for amino acid catabolism and gluconeogenesis
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    Title Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain
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    Title Increasing the Chemical-Shift Dispersion of Unstructured Proteins with a Covalent Lanthanide Shift Reagent
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    Title Changes in Colorectal Carcinoma Genomes under Anti-EGFR Therapy Identified by Whole-Genome Plasma DNA Sequencing
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    Title Adaptations of Energy Metabolism Associated with Increased Levels of Mitochondrial Cholesterol in Niemann-Pick Type C1-deficient Cells*
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    Title The Search for Antiaging Interventions: From Elixirs to Fasting Regimens
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    Title The Interplay of Protein Kinase A and Perilipin 5 Regulates Cardiac Lipolysis*?
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    Title External Validation of the Derived Neutrophil to Lymphocyte Ratio as a Prognostic Marker on a Large Cohort of Pancreatic Cancer Patients
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    Title Labeling, Human Mesenchymal Stromal Cells with Indium-111, SPECT Imaging
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    Title Mechanism of dual specificity kinase activity of DYRK1A
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    Title Bile acids induce arrhythmias in human atrial myocardium—implications for altered serum bile acid composition in patients with atrial fibrillation
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    Title Phospholipid Transfer Protein Is Expressed in Cerebrovascular Endothelial Cells and Involved in High Density Lipoprotein Biogenesis and Remodeling at the Blood-Brain Barrier*
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    Title Molecularly Distinct Routes of Mitochondrial Ca2+ Uptake Are Activated Depending on the Activity of the Sarco/Endoplasmic Reticulum Ca2+ ATPase (SERCA)*
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    Title Lipases
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    Title Endonuclease G mediates a-synuclein cytotoxicity during Parkinson's disease
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    Title The cell death protease Kex1p is essential for hypochlorite-induced apoptosis in yeast
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    Title Eukaryotic translation initiation factors in cancer development and progression
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    Title miR-181a is associated with poor clinical outcome in patients with colorectal cancer treated with EGFR inhibitor
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    Title Xanthohumol ameliorates atherosclerotic plaque formation, hypercholesterolemia, and hepatic steatosis in ApoE-deficient mice
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    Title Enzymatic synthesis of antibody-human serum albumin conjugate for targeted drug delivery using tyrosinase from Agaricus bisporus
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    Title NAT8L (N-Acetyltransferase 8-Like) Accelerates Lipid Turnover and Increases Energy Expenditure in Brown Adipocytes*
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    Title Mitochondrial Ca2+ uniporter (MCU)-dependent and MCU-independent Ca2+ channels coexist in the inner mitochondrial membrane
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    Title Mild Hypothermia Attenuates Circulatory and Pulmonary Dysfunction During Experimental Endotoxemia*
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    Title Selective targeting of genes regulated by zinc finger proteins in endometriosis and endometrioid adenocarcinoma by zinc niflumato complex with neocuproine
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    Title Lipolysis-derived fatty acids are needed for homeostatic control of sterol element-binding protein-1c driven hepatic lipogenesis
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    Title Annexin A5 controls VDAC1-dependent mitochondrial Ca2+ homeostasis and determines cellular susceptibility to apoptosis
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    Title Structural basis of phosphorylation-independent nuclear import of CIRBP by TNPO3
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    Title Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii 'GRAZ-2' from human faeces.
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    Title Targeting enhanced mitochondrial respiration chain activity as a potential therapeutic approach for endometriosis
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    Title Biodegradable ultrahigh-purity magnesium and its alloy ZX00 promote osteogenesis in the medullary cavity and glycogenolysis in the liver
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    Title A novel super-resolution STED microscopy analysis approach to observe spatial MCU and MICU1 distribution dynamics in cells
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    Title Development of a Dual Reporter System to Simultaneously Visualize Ca2+ Signals and AMPK Activity
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    Title Targeting organ-specific mitochondrial dysfunction to improve biological aging
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    Title Expanding the cultivable human archaeome: Methanobrevibacter intestini sp. nov. and strain Methanobrevibacter smithii “GRAZ-2” from human feces
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    Title The histone deacetylase HDAC1 controls dendritic cell development and anti-tumor immunity
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    Title Implications of mitochondrial membrane potential gradients on signaling and ATP production analyzed by correlative multi-parameter microscopy
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    Title Effect of astaxanthin in type-2 diabetes -induced APPxhQC transgenic and NTG mice
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    Title The link between amyloid ß and ferroptosis pathway in Alzheimer’s disease progression
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    Title Visualizing VDAC1 in live cells using a tetracysteine tag
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    Title 14-3-3 Protects against stress-induced apoptosis
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    Title miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms
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    Title Alterations in Lipid Metabolism Mediate Inflammation, Fibrosis, and Proliferation in a Mouse Model of Chronic Cholestatic Liver Injury
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    Title A new Canterbury tale: the eighth International Meeting on Yeast Apoptosis in Canterbury, UK, 2–6 May 2011
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    Title Adipose Triglyceride Lipase Contributes to Cancer-Associated Cachexia
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    Title Cross ß-Sheet Conformation of Keratin 8 Is a Specific Feature of Mallory–Denk Bodies Compared With Other Hepatocyte Inclusions
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    Title Processing of Endogenous AßPP in Blood-Brain Barrier Endothelial Cells is Modulated by Liver-X Receptor Agonists and Altered Cellular Cholesterol Homeostasis
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    Title The induction of mild hypothermia improves systolic function of the resuscitated porcine heart at no further sympathetic activation
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    Title Sequential Synthesis and Methylation of Phosphatidylethanolamine Promote Lipid Droplet Biosynthesis and Stability in Tissue Culture and in Vivo *
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    Title Reduced olfactory performance is associated with changed microbial diversity, oralization, and accumulation of dead biomaterial in the nasal olfactory area
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    Title Advanced Oxidation Protein Products Are Strongly Associated with the Serum Levels and Lipid Contents of Lipoprotein Subclasses in Healthy Volunteers and Patients with Metabolic Syndrome
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    Title Interindividual differences in aronia juice tolerability linked to gut microbiome and metabolome changes—secondary analysis of a randomized placebo-controlled parallel intervention trial
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    Title Regional Differences in the Small Intestinal Proteome of Control Mice and of Mice Lacking Lysosomal Acid Lipase
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    Title Spermidine alleviates depression via control of the stress response
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    Title Association of Small HDL Subclasses with Mortality Risk in Chronic Kidney Disease
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    Title E2F transcription factor-1 modulates expression of glutamine metabolic genes in mouse embryonic fibroblasts and uterine sarcoma cells
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    Title Genetically encoded fluorescent sensor to monitor intracellular arginine methylation
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    Title ATP regulates RNA-driven cold inducible RNA binding protein phase separation
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    Title Potassium ions promote hexokinase-II dependent glycolysis
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    Title Targeted Chemotherapy of Glioblastoma Spheroids with an Iontronic Pump
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    Title Dietary spermidine improves cognitive function
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    Title Growing Human Hepatocellular Tumors Undergo a Global Metabolic Reprogramming
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    Title Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease
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    Title Alteration of the Gut–Lung Axis After Severe COVID-19 Infection and Modulation Through Probiotics: A Randomized, Controlled Pilot Study
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    Title MCM proteins are up-regulated in placentas of women with reduced insulin sensitivity
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    Title Impaired HDL antioxidant and anti-inflammatory functions are linked to increased mortality in acute heart failure patients
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    Title Sex-Related Differences in the Associations between Adiponectin and Serum Lipoproteins in Healthy Subjects and Patients with Metabolic Syndrome
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    Title A surge in endogenous spermidine is essential for rapamycin-induced autophagy and longevity
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    Title Intestine-Specific Overexpression of Carboxylesterase 2c Protects Mice From Diet-Induced Liver Steatosis and Obesity
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    Title MiR-4646-5p Acts as a Tumor-Suppressive Factor in Triple Negative Breast Cancer and Targets the Cholesterol Transport Protein GRAMD1B
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    Title Associations between Endothelial Lipase, High-Density Lipoprotein, and Endothelial Function Differ in Healthy Volunteers and Metabolic Syndrome Patients
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    Title Glucose Metabolism and Metabolomic Changes in Response to Prolonged Fasting in Individuals with Obesity, Type 2 Diabetes and Non-Obese People—A Cohort Trial
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    Title Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer’s disease-related blood brain barrier dysfunction and inflammation
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    Title Glycoprotein Non-Metastatic Protein B (GPNMB): The Missing Link Between Lysosomes and Obesity
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    Title Fecal microbiota transplantation from individual with bipolar disorder and healthy control elicits distinct behaviors and metabolite profiles in mice
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    Title MiR-4649-5p acts as a tumor-suppressive microRNA in triple negative breast cancer by direct interaction with PIP5K1C, thereby potentiating growth-inhibitory effects of the AKT inhibitor capivasertib
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    Title Carboxylesterase 2a deletion provokes hepatic steatosis and insulin resistance in mice involving impaired diacylglycerol and lysophosphatidylcholine catabolism
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    Title Residual Humidity in Paraffin-Embedded Tissue Reduces Nucleic Acid Stability
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    Title Recent insights into lysosomal acid lipase deficiency
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    Title Acyl coenzyme A binding protein (ACBP): An aging- and disease-relevant “autophagy checkpoint”
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    Title Molecular targets of spermidine: implications for cancer suppression
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    Title Associations between Endothelial Lipase and Apolipoprotein B-Containing Lipoproteins Differ in Healthy Volunteers and Metabolic Syndrome Patients
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    Title Caloric Restriction Mimetics in Nutrition and Clinical Trials
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    Title Near-UV Light Induced ROS Production Initiates Spatial Ca2+ Spiking to Fire NFATc3 Translocation
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    Title Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia
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    Title Metabolic, Phenotypic, and Neuropathological Characterization of the Tg4-42 Mouse Model for Alzheimer’s Disease
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    Title Spermidine supplementation in rare translation-associated disorders
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    Title Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites
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    Title Dynamic Control of Mitochondrial Ca2+ Levels as a Survival Strategy of Cancer Cells
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    Title The rise of Candida auris: from unique traits to co-infection potential
    DOI 10.15698/mic2022.08.782
    Type Journal Article
    Author Egger N
    Journal Microbial Cell
    Pages 141
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  • 2022
    Title A pathological role of the Hsp40 protein Ydj1/DnaJA1 in models of Alzheimer’s disease
    DOI 10.15698/cst2022.05.267
    Type Journal Article
    Author Tadic J
    Journal Cell Stress
    Pages 61
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  • 2022
    Title FOXO transcription factors differ in their dynamics and intra/intermolecular interactions
    DOI 10.1016/j.crstbi.2022.04.001
    Type Journal Article
    Author Spreitzer E
    Journal Current Research in Structural Biology
    Pages 118-133
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  • 2022
    Title Off-target effects of the lysosomal acid lipase inhibitors Lalistat-1 and Lalistat-2 on neutral lipid hydrolases
    DOI 10.1016/j.molmet.2022.101510
    Type Journal Article
    Author Bradic I
    Journal Molecular Metabolism
    Pages 101510
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  • 2022
    Title p53 Regulates a miRNA-Fructose Transporter Axis in Brown Adipose Tissue Under Fasting
    DOI 10.3389/fgene.2022.913030
    Type Journal Article
    Author Reinisch I
    Journal Frontiers in Genetics
    Pages 913030
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  • 2022
    Title Characterization of DAG Binding to TRPC Channels by Target-Dependent cis–trans Isomerization of OptoDArG
    DOI 10.3390/biom12060799
    Type Journal Article
    Author Erkan-Candag H
    Journal Biomolecules
    Pages 799
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  • 2022
    Title Diacylglycerols interact with the L2 lipidation site in TRPC3 to induce a sensitized channel state
    DOI 10.15252/embr.202154276
    Type Journal Article
    Author Erkan-Candag H
    Journal The EMBO Reports
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  • 2022
    Title Sigma-1 Receptor Modulation by Ligands Coordinates Cancer Cell Energy Metabolism
    DOI 10.3390/biom12060762
    Type Journal Article
    Author Oflaz F
    Journal Biomolecules
    Pages 762
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  • 2022
    Title Effects of Spermidine Supplementation on Cognition and Biomarkers in Older Adults With Subjective Cognitive Decline
    DOI 10.1001/jamanetworkopen.2022.13875
    Type Journal Article
    Author Schwarz C
    Journal JAMA Network Open
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  • 2022
    Title Complementary omics strategies to dissect p53 signaling networks under nutrient stress
    DOI 10.1007/s00018-022-04345-8
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    Author Galhuber M
    Journal Cellular and Molecular Life Sciences
    Pages 326
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  • 2022
    Title MicroRNA mimics can distort physiological microRNA effects on immune checkpoints by triggering an antiviral interferon response
    DOI 10.1080/15476286.2022.2152978
    Type Journal Article
    Author Prinz F
    Journal RNA Biology
    Pages 1305-1315
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  • 2022
    Title Proteomic profiling of end-stage COVID-19 lung biopsies
    DOI 10.1186/s12014-022-09386-6
    Type Journal Article
    Author Gindlhuber J
    Journal Clinical Proteomics
    Pages 46
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  • 2017
    Title Dietary spermidine for lowering high blood pressure
    DOI 10.1080/15548627.2017.1280225
    Type Journal Article
    Author Eisenberg T
    Journal Autophagy
    Pages 767-769
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  • 2017
    Title Application of Genetically Encoded Fluorescent Nitric Oxide (NO•) Probes, the geNOps, for Real-time Imaging of NO• Signals in Single Cells
    DOI 10.3791/55486
    Type Journal Article
    Author Eroglu E
    Journal Journal of Visualized Experiments : JoVE
    Pages 55486
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  • 2017
    Title Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
    DOI 10.1016/j.cell.2017.02.031
    Type Journal Article
    Author Baar M
    Journal Cell
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  • 2017
    Title Catalytic competence, structure and stability of the cancer-associated R139W variant of the human NAD(P)H:quinone oxidoreductase 1 (NQO1)
    DOI 10.1111/febs.14051
    Type Journal Article
    Author Lienhart W
    Journal The FEBS Journal
    Pages 1233-1245
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  • 2017
    Title Monoglyceride lipase deficiency affects hepatic cholesterol metabolism and lipid-dependent gut transit in ApoE-/- mice
    DOI 10.18632/oncotarget.16529
    Type Journal Article
    Author Vujic N
    Journal Oncotarget
    Pages 33122-33136
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  • 2017
    Title Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo
    DOI 10.1038/s41467-017-01615-z
    Type Journal Article
    Author Bischof H
    Journal Nature Communications
    Pages 1422
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  • 2017
    Title Impact of Endothelial Lipase on Cholesterol Efflux Capacity of Serum and High-density Lipoprotein
    DOI 10.1038/s41598-017-12882-7
    Type Journal Article
    Author Schilcher I
    Journal Scientific Reports
    Pages 12485
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  • 2017
    Title N-Acetylaspartate Metabolism Outside the Brain: Lipogenesis, Histone Acetylation, and Cancer
    DOI 10.3389/fendo.2017.00240
    Type Journal Article
    Author Bogner-Strauss J
    Journal Frontiers in Endocrinology
    Pages 240
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  • 2017
    Title Cold-Induced Thermogenesis Depends on ATGL-Mediated Lipolysis in Cardiac Muscle, but Not Brown Adipose Tissue
    DOI 10.1016/j.cmet.2017.09.004
    Type Journal Article
    Author Schreiber R
    Journal Cell Metabolism
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  • 2017
    Title Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription
    DOI 10.1126/scisignal.aao0358
    Type Journal Article
    Author Frischauf I
    Journal Science Signaling
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  • 2017
    Title Mitochondrial energy metabolism is required for lifespan extension by the spastic paraplegia-associated protein spartin
    DOI 10.15698/mic2017.12.603
    Type Journal Article
    Author Ring J
    Journal Microbial Cell
    Pages 411
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  • 2017
    Title RNA structure refinement using NMR solvent accessibility data
    DOI 10.1038/s41598-017-05821-z
    Type Journal Article
    Author Hartlmüller C
    Journal Scientific Reports
    Pages 5393
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  • 2017
    Title Hepatocellular carcinomas with intracellular hyaline bodies have a poor prognosis
    DOI 10.1111/liv.13325
    Type Journal Article
    Author Aigelsreiter A
    Journal Liver International
    Pages 600-610
  • 2017
    Title Cytosolic lipolysis and lipophagy: two sides of the same coin
    DOI 10.1038/nrm.2017.76
    Type Journal Article
    Author Zechner R
    Journal Nature Reviews Molecular Cell Biology
    Pages 671-684
  • 2017
    Title Real-time visualization of distinct nitric oxide generation of nitric oxide synthase isoforms in single cells
    DOI 10.1016/j.niox.2017.09.001
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    Author Eroglu E
    Journal Nitric Oxide
    Pages 59-67
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  • 2017
    Title UCP2 and PRMT1 are key prognostic markers for lung carcinoma patients
    DOI 10.18632/oncotarget.20571
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    Journal Oncotarget
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    Title Integrative metabolomics as emerging tool to study autophagy regulation
    DOI 10.15698/mic2017.08.584
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    Author Stryeck S
    Journal Microbial Cell
    Pages 240
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  • 2017
    Title Lysophosphatidic acid via LPA-receptor 5/protein kinase D-dependent pathways induces a motile and pro-inflammatory microglial phenotype
    DOI 10.1186/s12974-017-1024-1
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    Author Plastira I
    Journal Journal of Neuroinflammation
    Pages 253
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  • 2017
    Title Dipeptidyl peptidase-4 independent cardiac dysfunction links saxagliptin to heart failure
    DOI 10.1016/j.bcp.2017.08.021
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    Author Koyani C
    Journal Biochemical Pharmacology
    Pages 64-80
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  • 2017
    Title Implications of cerebrovascular ATP-binding cassette transporter G1 (ABCG1) and apolipoprotein M in cholesterol transport at the blood-brain barrier
    DOI 10.1016/j.bbalip.2017.03.003
    Type Journal Article
    Author Kober A
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
    Pages 573-588
  • 2017
    Title Genome-Wide miRNA Analysis Identifies miR-188-3p as a Novel Prognostic Marker and Molecular Factor Involved in Colorectal Carcinogenesis
    DOI 10.1158/1078-0432.ccr-16-0497
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    Author Pichler M
    Journal Clinical Cancer Research
    Pages 1323-1333
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  • 2017
    Title Non-Orai Partners of STIM Proteins
    DOI 10.1201/9781315152592-10
    Type Book Chapter
    Author Groschner K
    Publisher Taylor & Francis
    Pages 177-196
  • 2017
    Title SOX9 is a proliferation and stem cell factor in hepatocellular carcinoma and possess widespread prognostic significance in different cancer types
    DOI 10.1371/journal.pone.0187814
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    Journal PLOS ONE
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  • 2017
    Title Cardiovascular and Hemostatic Disorders: SOCE in Cardiovascular Cells: Emerging Targets for Therapeutic Intervention
    DOI 10.1007/978-3-319-57732-6_24
    Type Book Chapter
    Author Groschner K
    Publisher Springer Nature
    Pages 473-503
  • 2017
    Title Regulatory effects of simvastatin and apoJ on APP processing and amyloid-ß clearance in blood-brain barrier endothelial cells
    DOI 10.1016/j.bbalip.2017.09.008
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    Author Zandl-Lang M
    Journal Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
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  • 2017
    Title miR-196b-5p Regulates Colorectal Cancer Cell Migration and Metastases through Interaction with HOXB7 and GALNT5
    DOI 10.1158/1078-0432.ccr-17-0023
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    Author Stiegelbauer V
    Journal Clinical Cancer Research
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  • 2017
    Title Na+/Ca2+ exchangers and Orai channels jointly refill endoplasmic reticulum (ER) Ca2+ via ER nanojunctions in vascular endothelial cells
    DOI 10.1007/s00424-017-1989-8
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    Journal Pflügers Archiv - European Journal of Physiology
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  • 2017
    Title APMAP interacts with lysyl oxidase–like proteins, and disruption of Apmap leads to beneficial visceral adipose tissue expansion
    DOI 10.1096/fj.201601337r
    Type Journal Article
    Author Pessentheiner A
    Journal The FASEB Journal
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    Title Lysosomal lipid hydrolysis provides substrates for lipid mediator synthesis in murine macrophages
    DOI 10.18632/oncotarget.16673
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    Journal Oncotarget
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  • 2017
    Title Corrigendum: Pharmacological Characterization of the Native Store-Operated Calcium Channels of Cortical Neurons from Embryonic Mouse Brain
    DOI 10.3389/fphar.2017.00152
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    Journal Frontiers in Pharmacology
    Pages 152
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