Komplexe Biomaterialien: Züchtung von mimetisch epithelialer
Complex biomaterials: engineering mimetic epithelial tissue
Balazs Dome
(ORCID: 0000-0001-8799-8624)
Bilaterale Ausschreibung: Ungarn
Wissenschaftsdisziplinen
Biologie (60%); Klinische Medizin (40%)
Keywords
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Tissue Mechanics,
Electrospinning,
Imaging,
Excracellular Matrix,
Tumor Microenvironment
Das Adenokarzinom der Lunge stellt einen aggressiven Tumor mit hoher Mortalität dar. Die vorgeschlagene Forschungsarbeit bietet eine neue Experimentalumgebung um die einzelnen Schritte der Tumorprogression genauer zu erforschen. Durch die künstliche Erzeugung von epithelialem Oberflächengewebe mittels 3D Druckverfahren, können somit zukünftig potentielle Wirkstoffe noch effektiver getestet werden. Diese Ansätze können zukünftig zu einer effektiveren, personalisierten Medizin führen, da Patienten von einer individualisierten, dem jeweiligen Tumor angepassten, Therapie profitieren können.
Forschungsstätte(n)
Internationale Projektbeteiligte
- Elöd Mehes, Eotvos Lorand University - Ungarn
- Istvan Groma, Eötvös Loránd University - Ungarn
- Andras Czirok, Eötvös University of Sciences Budapest - Ungarn
- Franciska Erdö, Pazmany Peter Katolikus Egyetem - Ungarn
Research Output
- 1293 Zitationen
- 64 Publikationen
Publikationen
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2025
Titel Inhibition of YB-1 phosphorylation enhances cisplatin activity and disrupts cell division in pleural mesothelioma DOI 10.1038/s41416-025-03177-0 Typ Journal Article Autor Schelch K Journal British Journal of Cancer Seiten 1391-1400 Link Publikation -
2025
Titel Clinical Significance of Time-to-Surgery and COVID-19 Pandemic in Surgically Treated Non-Small Cell Lung Cancer DOI 10.1111/1759-7714.70163 Typ Journal Article Autor Ghimessy Á Journal Thoracic Cancer Link Publikation -
2025
Titel Using 18F-FDG PET/CT-derived body composition features to predict lymphovascular invasion in non-small cell lung cancer DOI 10.1007/s00259-025-07435-4 Typ Journal Article Autor Jiang Z Journal European Journal of Nuclear Medicine and Molecular Imaging Seiten 1-12 Link Publikation -
2025
Titel Impact of KRAS mutation subtypes on morphological heterogeneity and immune landscape in surgically treated lung adenocarcinoma DOI 10.21037/tlcr-2024-1092 Typ Journal Article Autor Torok K Journal Translational Lung Cancer Research Seiten 1914-1928 Link Publikation -
2025
Titel Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells DOI 10.1016/j.jhazmat.2025.139129 Typ Journal Article Autor Ernhofer B Journal Journal of Hazardous Materials Seiten 139129 Link Publikation -
2023
Titel Primary and hTERT-Transduced Mesothelioma-Associated Fibroblasts but Not Primary or hTERT-Transduced Mesothelial Cells Stimulate Growth of Human Mesothelioma Cells DOI 10.3390/cells12152006 Typ Journal Article Autor Ries A Journal Cells Seiten 2006 Link Publikation -
2023
Titel Targeting YB-1 via entinostat enhances cisplatin sensitivity of pleural mesothelioma in vitro and in vivo DOI 10.1016/j.canlet.2023.216395 Typ Journal Article Autor Schelch K Journal Cancer Letters Seiten 216395 Link Publikation -
2023
Titel Entinostat enhances the efficacy of chemotherapy in small cell lung cancer through S-phase arrest and decreased base excision repair DOI 10.1158/1078-0432.ccr-23-1795 Typ Journal Article Autor Solta A Journal Clinical Cancer Research Seiten 4644-4659 Link Publikation -
2023
Titel Circulating FGF18 is decreased in pleural mesothelioma but not correlated with disease prognosis DOI 10.1111/1759-7714.15004 Typ Journal Article Autor Mosleh B Journal Thoracic Cancer Seiten 2177-2186 Link Publikation -
2023
Titel Laser ablation-inductively coupled plasma-mass spectrometry analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma DOI 10.1111/bcp.15813 Typ Journal Article Autor Tisza A Journal British Journal of Clinical Pharmacology Seiten 3364-3374 Link Publikation -
2023
Titel Clinical insights into small cell lung cancer: Tumor heterogeneity, diagnosis, therapy, and future directions DOI 10.3322/caac.21785 Typ Journal Article Autor Megyesfalvi Z Journal CA: A Cancer Journal for Clinicians Seiten 620-652 Link Publikation -
2023
Titel Comparative expression analysis of immune-related markers in surgically resected lung neuroendocrine neoplasms DOI 10.1016/j.lungcan.2023.107263 Typ Journal Article Autor Ferencz B Journal Lung Cancer Seiten 107263 Link Publikation -
2023
Titel Unfolding the secrets of small cell lung cancer progression: Novel approaches and insights through rapid autopsies DOI 10.1016/j.ccell.2023.08.007 Typ Journal Article Autor Megyesfalvi Z Journal Cancer Cell Seiten 1535-1540 Link Publikation -
2023
Titel Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma DOI 10.1016/j.lungcan.2023.107360 Typ Journal Article Autor Stockhammer P Journal Lung Cancer Seiten 107360 Link Publikation -
2022
Titel Malignant pleural mesothelioma nodules remodel their surroundings to vascularize and grow DOI 10.21037/tlcr-21-828 Typ Journal Article Autor Kovacs I Journal Translational Lung Cancer Research Seiten 0-0 Link Publikation -
2025
Titel Comprehensive biobanking strategy with clinical impact at the European Cancer Moonshot Lund Center DOI 10.1016/j.jprot.2025.105442 Typ Journal Article Autor Oskolas H Journal Journal of Proteomics Seiten 105442 Link Publikation -
2025
Titel Expression of costimulatory molecule CD70 is prognostic in small cell lung cancer DOI 10.1007/s00262-025-04006-2 Typ Journal Article Autor Dora D Journal Cancer Immunology, Immunotherapy Seiten 165 Link Publikation -
2025
Titel Comparative profiling of surgically resected primary tumors and their lymph node metastases in small-cell lung cancer DOI 10.1016/j.esmoop.2025.104514 Typ Journal Article Autor Csende K Journal ESMO Open Seiten 104514 Link Publikation -
2025
Titel Unveiling the powerhouse: ASCL1-driven small cell lung cancer is characterized by higher numbers of mitochondria and enhanced oxidative phosphorylation DOI 10.1186/s40170-025-00382-6 Typ Journal Article Autor Solta A Journal Cancer & Metabolism Seiten 16 Link Publikation -
2025
Titel 303P: Identifying novel prognostic markers in small cell lung cancer through comprehensive in-silico analysis DOI 10.1016/s1556-0864(25)00495-2 Typ Journal Article Autor Teglas V Journal Journal of Thoracic Oncology -
2024
Titel Expression patterns of novel immunotherapy targets in intermediate- and high-grade lung neuroendocrine neoplasms DOI 10.1007/s00262-024-03704-7 Typ Journal Article Autor Ferencz B Journal Cancer Immunology, Immunotherapy Seiten 114 Link Publikation -
2024
Titel Small cells – big issues: biological implications and preclinical advancements in small cell lung cancer DOI 10.1186/s12943-024-01953-9 Typ Journal Article Autor Solta A Journal Molecular Cancer Seiten 41 Link Publikation -
2024
Titel C-Myc protein expression indicates unfavorable clinical outcome in surgically resected small cell lung cancer DOI 10.1186/s12957-024-03315-7 Typ Journal Article Autor Lang C Journal World Journal of Surgical Oncology Seiten 57 Link Publikation -
2023
Titel PD-1 and PD-L1 expression in rare lung tumors DOI 10.3389/pore.2023.1611164 Typ Journal Article Autor Gyulai M Journal Pathology & Oncology Research Seiten 1611164 Link Publikation -
2023
Titel Non-small cell lung cancer patients treated with Anti-PD1 immunotherapy show distinct microbial signatures and metabolic pathways according to progression-free survival and PD-L1 status DOI 10.1080/2162402x.2023.2204746 Typ Journal Article Autor Dora D Journal OncoImmunology Seiten 2204746 Link Publikation -
2023
Titel Candida expansion in the gut of lung cancer patients associates with an ecological signature that supports growth under dysbiotic conditions DOI 10.1038/s41467-023-38058-8 Typ Journal Article Autor Seelbinder B Journal Nature Communications Seiten 2673 Link Publikation -
2023
Titel Mesothelioma-associated fibroblasts enhance proliferation and migration of pleural mesothelioma cells via c-Met/PI3K and WNT signaling but do not protect against cisplatin DOI 10.1186/s13046-022-02582-0 Typ Journal Article Autor Ries A Journal Journal of Experimental & Clinical Cancer Research Seiten 27 Link Publikation -
2023
Titel YB-1 regulates mesothelioma cell migration via snail but not EGFR, MMP1, EPHA5 or PARK2 DOI 10.1002/1878-0261.13367 Typ Journal Article Autor Schelch K Journal Molecular Oncology Seiten 815-831 Link Publikation -
2023
Titel LA-ICP-MS analysis reveals differences in chemotherapeutic drug distribution in surgically resected pleural mesothelioma DOI 10.22541/au.167275573.37513553/v1 Typ Preprint Autor Tisza A Link Publikation -
2023
Titel Dual targeting of BCL-2 and MCL-1 in the presence of BAX breaks venetoclax resistance in human small cell lung cancer DOI 10.1038/s41416-023-02219-9 Typ Journal Article Autor Valko Z Journal British Journal of Cancer Seiten 1850-1861 Link Publikation -
2024
Titel Machine Learning-enhanced X-ray-based Radiomics in the Identification of Post-COVID Patients DOI 10.1016/j.arbres.2024.12.004 Typ Journal Article Autor Fulop A Journal Archivos de Bronconeumología Seiten 232-234 Link Publikation -
2024
Titel High circulating activin A plasma levels are associated with tumour stage and poor survival in treatment-naive lung squamous cell cancer patients DOI 10.1016/j.tranon.2024.102153 Typ Journal Article Autor Sinn K Journal Translational Oncology Seiten 102153 Link Publikation -
2024
Titel Prophylactic cranial irradiation for small cell lung cancer in the era of immunotherapy and molecular subtypes DOI 10.1097/cco.0000000000001111 Typ Journal Article Autor Pozonec V Journal Current Opinion in Oncology Seiten 27-34 Link Publikation -
2023
Titel Computed Tomography-Based Quantitative Texture Analysis and Gut Microbial Community Signatures Predict Survival in Non-Small Cell Lung Cancer DOI 10.3390/cancers15205091 Typ Journal Article Autor Dora D Journal Cancers Seiten 5091 Link Publikation -
2023
Titel HUNCHEST-II contributes to a shift to earlier-stage lung cancer detection: final results of a nationwide screening program DOI 10.1007/s00330-023-10379-8 Typ Journal Article Autor Kerpel-Fronius A Journal European Radiology Seiten 3462-3470 -
2025
Titel Prospective validation of ORACLE, a clonal expression biomarker associated with survival of patients with lung adenocarcinoma DOI 10.1038/s43018-024-00883-1 Typ Journal Article Autor Biswas D Journal Nature Cancer Seiten 86-101 Link Publikation -
2025
Titel Diagnostic and prognostic relevance of inflammatory markers in surgically treated thymic epithelial tumors: An international multicenter study DOI 10.1016/j.lungcan.2025.108111 Typ Journal Article Autor Megyesfalvi E Journal Lung Cancer Seiten 108111 Link Publikation -
2025
Titel Deep Learning–Based Retinoblastoma Protein Subtyping of Pulmonary Large-Cell Neuroendocrine Carcinoma on Small Hematoxylin and Eosin–Stained Specimens DOI 10.1016/j.labinv.2025.104192 Typ Journal Article Autor Trandafir T Journal Laboratory Investigation Seiten 104192 Link Publikation -
2022
Titel Non-Small Cell Lung Cancer Patients Treated with Anti-PD1 Immunotherapy Show Distinct Microbial Signatures and Metabolic Pathways According to Clinical Outcomes DOI 10.1101/2022.10.05.22280734 Typ Preprint Autor Dora D Seiten 2022.10.05.22280734 Link Publikation -
2025
Titel Small Particles, Big Problems: Polystyrene nanoparticles induce DNA damage, oxidative stress, migration, and mitogenic pathways predominantly in non-malignant lung cells DOI 10.1101/2025.03.24.644975 Typ Preprint Autor Ernhofer B Seiten 2025.03.24.644975 Link Publikation -
2022
Titel In-depth proteomic analysis reveals unique subtype-specific signatures in human small-cell lung cancer DOI 10.1002/ctm2.1060 Typ Journal Article Autor Szeitz B Journal Clinical and Translational Medicine Link Publikation -
2022
Titel Proteomic analysis of brain metastatic lung adenocarcinoma reveals intertumoral heterogeneity and specific alterations associated with the timing of brain metastases DOI 10.1016/j.esmoop.2022.100741 Typ Journal Article Autor Woldmar N Journal ESMO Open Seiten 100741 Link Publikation -
2022
Titel Protein Expression of immune checkpoints STING and MHCII in small cell lung cancer DOI 10.1007/s00262-022-03270-w Typ Journal Article Autor Dora D Journal Cancer Immunology, Immunotherapy Seiten 561-578 Link Publikation -
2022
Titel Clinical and prognostic implications of CD47 and PD-L1 expression in surgically resected small-cell lung cancer DOI 10.1016/j.esmoop.2022.100631 Typ Journal Article Autor Lang C Journal ESMO Open Seiten 100631 Link Publikation -
2022
Titel Nationwide lung cancer screening with low-dose computed tomography: implementation and first results of the HUNCHEST screening program DOI 10.1007/s00330-022-08589-7 Typ Journal Article Autor Kerpel-Fronius A Journal European Radiology Seiten 4457-4467 -
2022
Titel Lymphocyte-to-monocyte ratio is an independent prognostic factor in surgically treated small cell lung cancer: An international multicenter analysis DOI 10.1016/j.lungcan.2022.05.010 Typ Journal Article Autor Lang C Journal Lung Cancer Seiten 40-46 Link Publikation -
2021
Titel Bone-Specific Metastasis Pattern of Advanced-Stage Lung Adenocarcinoma According to the Localization of the Primary Tumor DOI 10.3389/pore.2021.1609926 Typ Journal Article Autor Radeczky P Journal Pathology & Oncology Research Seiten 1609926 Link Publikation -
2021
Titel Oncofetal Chondroitin Sulfate Is a Highly Expressed Therapeutic Target in Non-Small Cell Lung Cancer DOI 10.3390/cancers13174489 Typ Journal Article Autor Oo H Journal Cancers Seiten 4489 Link Publikation -
2021
Titel Clinical relevance of circulating activin A and follistatin in small cell lung cancer DOI 10.1016/j.lungcan.2021.09.008 Typ Journal Article Autor Barany N Journal Lung Cancer Seiten 128-135 Link Publikation -
2021
Titel Characterization of Tumor-Associated Macrophages and the Immune Microenvironment in Limited-Stage Neuroendocrine-High and -Low Small Cell Lung Cancer DOI 10.3390/biology10060502 Typ Journal Article Autor Dora D Journal Biology Seiten 502 Link Publikation -
2021
Titel Down-regulation of A20 promotes immune escape of lung adenocarcinomas DOI 10.1126/scitranslmed.abc3911 Typ Journal Article Autor Breitenecker K Journal Science Translational Medicine Link Publikation -
2020
Titel Comparative analysis of prognostic histopathologic parameters in subtypes of epithelioid pleural mesothelioma DOI 10.1111/his.14105 Typ Journal Article Autor Bilecz A Journal Histopathology Seiten 55-66 Link Publikation -
2020
Titel Neuroendocrine subtypes of small cell lung cancer differ in terms of immune microenvironment and checkpoint molecule distribution DOI 10.1002/1878-0261.12741 Typ Journal Article Autor Dora D Journal Molecular Oncology Seiten 1947-1965 Link Publikation -
2020
Titel Proteomic analysis enables distinction of early- versus advanced-stage lung adenocarcinomas DOI 10.1002/ctm2.106 Typ Journal Article Autor Kelemen O Journal Clinical and Translational Medicine Link Publikation -
2020
Titel Current therapy of KRAS-mutant lung cancer DOI 10.1007/s10555-020-09903-9 Typ Journal Article Autor Ghimessy A Journal Cancer and Metastasis Reviews Seiten 1159-1177 Link Publikation -
2021
Titel Distinct composition and metabolic functions of human gut microbiota are associated with cachexia in lung cancer patients DOI 10.1038/s41396-021-00998-8 Typ Journal Article Autor Ni Y Journal The ISME Journal Seiten 3207-3220 Link Publikation -
2021
Titel Prognostic impact of PD-1 and PD-L1 expression in malignant pleural mesothelioma: an international multicenter study DOI 10.21037/tlcr-20-1114 Typ Journal Article Autor Brcic L Journal Translational Lung Cancer Research Seiten 1594-1607 Link Publikation -
2021
Titel Molecular profiles of small cell lung cancer subtypes: Therapeutic implications DOI 10.1016/j.omto.2021.02.004 Typ Journal Article Autor Schwendenwein A Journal Molecular Therapy - Oncolytics Seiten 470-483 Link Publikation -
2021
Titel The landscape of small cell lung cancer metastases: Organ specificity and timing DOI 10.1111/1759-7714.13854 Typ Journal Article Autor Megyesfalvi Z Journal Thoracic Cancer Seiten 914-923 Link Publikation -
2021
Titel Allosteric and ATP-Competitive MEK-Inhibition in a Novel Spitzoid Melanoma Model with a RAF- and Phosphorylation-Independent Mutation DOI 10.3390/cancers13040829 Typ Journal Article Autor Hegedüs L Journal Cancers Seiten 829 Link Publikation -
2021
Titel The effects of bisphosphonate and radiation therapy in bone-metastatic lung adenocarcinoma: the impact of KRAS mutation DOI 10.21037/tlcr-20-754 Typ Journal Article Autor Radeczky P Journal Translational Lung Cancer Research Seiten 675-684 Link Publikation -
2021
Titel EGFR variant allele frequency predicts EGFR-TKI efficacy in lung adenocarcinoma: a multicenter study DOI 10.21037/tlcr-20-814 Typ Journal Article Autor Gieszer B Journal Translational Lung Cancer Research Seiten 662-674 Link Publikation -
2021
Titel Apelin promotes blood and lymph vessel formation and the growth of melanoma lung metastasis DOI 10.1038/s41598-021-85162-0 Typ Journal Article Autor Berta J Journal Scientific Reports Seiten 5798 Link Publikation -
2022
Titel Expression patterns and prognostic relevance of subtype-specific transcription factors in surgically resected small-cell lung cancer: an international multicenter study DOI 10.1002/path.5922 Typ Journal Article Autor Megyesfalvi Z Journal The Journal of Pathology Seiten 674-686 Link Publikation