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PAIR - Pre-clinical Ion Beam Research

PAIR - Pre-clinical Ion Beam Research

Dietmar Georg (ORCID: 0000-0002-8327-3877)
  • Grant DOI 10.55776/DFH13
  • Funding program doc.funds.connect
  • Status ongoing
  • Start May 1, 2022
  • End April 30, 2026
  • Funding amount € 1,005,148
  • E-mail

Disciplines

Computer Sciences (20%); Medical-Theoretical Sciences, Pharmacy (40%); Medical Engineering (40%)

Keywords

    Ion beam therapy, Pre-Clinical Research, Radiation Response, Ultra-High Field Mri, Molecular Radiobiology, Bioinformatics

Abstract

Ion beam therapy using protons and Carbon ion beam is the most advanced form of cancer treatment with ionizing radiation. Ion beams have superior physical as well as biological properties compared to photon therapy. Inter-disciplinary pre-clinical research based on tumor models is essential for future developments in the field of ion beam therapy. The PAIR project aims to close the gap in radiobiological knowledge of ion beams at the molecular, cellular and tissue level. Five complementary and interconnected PhD projects will link biology-physics-medicine, with a focus on genomics and proteomics analysis of models and high-resolution non-invasive imaging. A novel PhD program with interdisciplinary courses strengthens the academic education of PhD students. PAIR utilizes a unique ion beam research infrastructure at the Ion beam facility MedAustron and builds on the strengths of the Medical University of Vienna, the University of Veterinary Medicine Vienna and the University of Applied Sciences Wiener Neustadt with experts in medical radiation physics, imaging, molecular biology and computational sciences. The project strengthens innovation in Austria by creating an academic network for imaging and biology-oriented cancer research and education.

Consortium
  • Barabara Knäusl, Medizinische Universität Wien
    consortium member (01.05.2022 -)
  • Birgit Strobl, Veterinärmedizinische Universität Wien
    consortium member (01.05.2022 -)
  • Dea Slade, Medizinische Universität Wien
    consortium member (01.05.2022 -)
  • Dietmar Georg, Medizinische Universität Wien
    consortium member (01.05.2022 -)
  • Ingo Feinerer, Fachhochschule Wiener Neustadt GmbH
    consortium member (01.05.2022 -)
  • Markus Zeilinger, Fachhochschule Wiener Neustadt GmbH
    consortium member (01.05.2022 -)
  • Milica Krunic, Fachhochschule Wiener Neustadt GmbH
    consortium member (01.05.2022 -)
  • Thomas Helbich, Medizinische Universität Wien
    consortium member (01.05.2022 -)
Research institution(s)
  • Medizinische Universität Wien
Project participants
  • Thomas Schreiner, national collaboration partner

Research Output

  • 7 Citations
  • 7 Publications
  • 2 Methods & Materials
Publications
  • 2026
    Title Pre-Clinical Data Science in Ion-Beam Research
    Type PhD Thesis
    Author Abdarahmane, Isselmou
  • 2026
    Title Multiparametric Magnetic Resonance Imaging in preclinical research: Medical physics aspects
    Type PhD Thesis
    Author Stocchiero, Silvia
  • 2026
    Title Dosimetric aspects of image guided preclinical ion beam research
    Type PhD Thesis
    Author Langgartner, Lorenz
  • 2026
    Title Biological effects of particle beam therapy on pancreatic cancer
    Type PhD Thesis
    Author Pichler, Sebastian
  • 2026
    Title Differential cellular responses to radiation
    Type PhD Thesis
    Author Dias, Ana Beatriz
  • 2023
    Title Requirements for dose calculation on an active scanned proton beamline for small, shallow fields
    DOI 10.1016/j.ejmp.2023.102659
    Type Journal Article
    Author Knäusl B
    Journal Physica Medica
    Pages 102659
    Link Publication
  • 2024
    Title Dosimetric characteristics of 3D-printed and epoxy-based materials for particle therapy phantoms
    DOI 10.3389/fphy.2024.1323788
    Type Journal Article
    Author Brunner J
    Journal Frontiers in Physics
    Pages 1323788
    Link Publication
Methods & Materials
  • 2023
    Title Setup for precision proton irradiation of animal models
    Type Improvements to research infrastructure
    Public Access
  • 0
    Title High precision X-ray irradiator
    Type Improvements to research infrastructure

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office(at)fwf.ac.at
+43 1 505 67 40

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