CavX – Calcium channels in excitable cells

Theoretical framework. Voltage gated Ca2+ channels (CaV) play a central role in cellular excitability, neurotransmitter and hormone release, muscle contraction, gene transcription, cell differentiation and survival. Accordingly, ion channel research is crucial for understanding the aetiology of many neurological and endocrine dysfunctions as well as for the design of pharmacological interventions. Here we propose a PhD program focused on investigating the complex role of CaV channels in different tissues and training of future ion channel researchers. Hypotheses and questions. We hypothesize that a holistic view across many different cell types of CaV channels function and modulation will reveal the specific roles of CaV channels in human physiology and pathophysiology. We will investigate how CaV channels and their modulators control central nervous system and sensory neurons synaptic function, pancreatic endocrine cell hormone release, and muscle contraction. Approach. Our research includes a comprehensive array of methods like electrophysiology and pharmacology, unique animal models and cell culture systems, fluorescence imaging, biochemistry, molecular biology, genetic engineering, structure modelling and molecular dynamics simulation. Being part of a scientific network like CaVX affords all participating labs easy access to all of these technologies and expertise. Faculty. The Innsbruck Ca2+ channel research cluster with its worldwide unique concentration of CaV research teams reached a critical mass of young researchers focused on the role of CaV channels from structure to function and pharmacology in many different tissues. Our team is formed by Monica L. Fernndez-Quintero, Alexandra Koschak, Dirk Meyer, Nadine Ortner and Petronel Tuluc from the University of Innsbruck and Marta Campiglio amd Christian Vogl from the Medical University of Innsbruck. Added value. CaVX complements the Neuroscience PhD program of the PhD School for Biomedical Sciences at the Medical University Innsbruck and the Centre for Molecular Biosciences (CMBI) at Leopold Franzens University of Innsbruck with specific expertise and teaching on ion channels. Besides the scientific advancements, CaVX will deliver PhD students comprehensively trained in the key techniques applied in current ion channel research. Due to our strong collaboration and joint research projects the PhD students will have a high understanding of ion channels structure, function, role in physiology, pathophysiology and pharmacology. For the faculty, CaVX facilitates interdisciplinary research projects, privileged access to a wide range of methods and know-how as well as a highly motivating and supportive research environment. Additionally, CaVX will substantially contribute to the local and national research infrastructure and ultimately increase the international visibility of Austrian research.