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Towards prevention and therapy of allergy

Towards prevention and therapy of allergy

Rudolf Valenta (ORCID: 0000-0001-5944-3365)
  • Grant DOI 10.55776/F46
  • Funding program Special Research Areas
  • Status ended
  • Start February 1, 2012
  • End July 31, 2020
  • Funding amount € 10,099,091
  • Project website

Disciplines

Clinical Medicine (70%); Medical-Theoretical Sciences, Pharmacy (30%)

Keywords

    House dust mite allergy, Recombinant Allergen, Diagnosis, Hypoallergen Derivative, Immunotherapy

Abstract

Within the proposed project program "Towards prevention and therapy of allergy" a multidisciplinary group of scientists has joined to develop new forms of prevention and therapy for allergy. IgEassociated allergies represent a severe health problem in industrialized countries because of their continuously increasing prevalence. Allergy affects more than 25% of the population and, if not properly diagnosed and treated, often progresses to severe and disabling manifestations such as asthma. The research team builds on more than 20 years of experience in the molecular and immunological characterization of disease-causing allergens. Now they plan to use clinically important allergens to develop new forms of prevention and treatment which target allergic diseases from various aspects. One of the major long term goals is the development of allergenspecific prevention strategies for allergic diseases.

Consortium
  • Barbara Bohle, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Erika Jensen-Jarolim, Veterinärmedizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Heimo Breiteneder, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.01.2016)
  • Karin Hoffmann-Sommergruber, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Peter Valent, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.01.2016)
  • Rudolf Valenta, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Sabine Flicker, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Susanne Vrtala, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Ursula Wiedermann-Schmidt, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Verena Niederberger-Leppin, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Walter Keller, Universität Graz
    consortium member (01.02.2012 - 31.07.2020)
  • Winfried F. Pickl, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
  • Zsolt Szepfalusi, Medizinische Universität Wien
    consortium member (01.02.2012 - 31.07.2020)
Research institution(s)
  • Medizinische Universität Wien
Project participants
  • Joshua Tobias, Medizinische Universität Wien , national collaboration partner
International project participants
  • Andreas L. Lopata, James Cook University - Australia
  • Mimi L.K. Tang, Murdoch Childrens Research Institute - Australia
  • Wayne R. Thomas, The University of Western Australia - Australia
  • Claus Bachert, Ghent University - Belgium
  • Han Remaut, Vrije Universiteit Brussel - Belgium
  • Ana Paula Valente, Universidade Federal de Rio de Janeiro - Brazil
  • Oliver Perez, Finlay Institute - Cuba
  • Vladislav Krzyzanek, Academy of Sciences of the Czech Republic - Czechia
  • Martin Schwarzer, Academy of Sciences of the Czech Republic - Czechia
  • Hana Kozakova, Academy of Sciences of the Czech Republic - Czechia
  • Edzard Spillner, Aarhus University - Denmark
  • Hans-Jorgen Malling, National University Hospital - Denmark
  • Lars K. Poulsen, National University Hospital Copenhagen - Denmark
  • Kirsten Skamstrup Hansen, University Hospital of Gentofte - Denmark
  • Jean Bousquet, Université Montpellier - France
  • Bruno Pot, Institut Pasteur de Lille - France
  • Graca Raposo, Institut Curie - France
  • Kavita Reginald, Université Marseille - France
  • Michel Arock, CHU Pitié-Salpêtrière - France
  • Gabrielle Pauli, C.H.U. Strasbourg Hopitaux Universitaires de Strasbourg - France
  • Frédéric De Blay, C.H.U. Strasbourg Hopitaux Universitaires de Strasbourg - France
  • Clotilde Thery, Institut Curie - France
  • Janet Vonck, Max-Planck-Institut für Biophysik - Germany
  • Wolfgang Pfützner, Universitätsklinikum Gießen und Marburg - Germany
  • Claudia Traidl-Hoffmann, Universitätsklinikum Augsburg - Germany
  • Peter König, Universität Lübeck - Germany
  • Simon Blank, Technische Universität und Helmholtz Zentrum München - Germany
  • Natalija Novak, Rheinische Friedrich-Wilhelms-Universität Bonn - Germany
  • Harald Renz, Philipps-Universität Marburg - Germany
  • Stefan Vieths, Paul-Ehrlich-Institut - Germany
  • Dirk Schiller, Paul-Ehrlich-Institut - Germany
  • Thomas Werfel, Medizinische Hochschule Hannover - Germany
  • Ronald Naumann, Max-Planck-Gesellschaft - Germany
  • Christian Möbs, Universitätsklinikum Gießen und Marburg - Germany
  • Hans Peter Horny, Ludwig Maximilians-Universität München - Germany
  • Ludger Klimek, Allergiezentrum Wiesbaden - Germany
  • Andreas Nandy, Allergopharma J. Ganzer KG - Germany
  • Helga Kahlert, Allergopharma J. Ganzer KG - Germany
  • Helmut Fiebig, Allergopharma J. Ganzer KG - Germany
  • Roland Suck, Allergopharma J. Ganzer KG - Germany
  • Ralf S. Müller, Ludwig Maximilians-Universität München - Germany
  • Dmitri I. Svergun, European Molecular Biology Laboratory Hamburg - Germany
  • Fabio Dall´Antonia, European Molecular Biology Laboratory Hamburg - Germany
  • Erika Von Mutius, Klinikum der Ludwig-Maximilians-Universität München - Germany
  • Paolo Matricardi, Charité - Universitätsmedizin Berlin - Germany
  • Michael Kabesch, Krankenhaus der Barmherzigen Brüder, Regensburg - Germany
  • Dimitar Efremov, International Centre for Genetic Engineering and Biotechnology - Italy
  • Adriano Mari, Istituto Dermopatico dell´Immacolata - Italy
  • Stefano Alessandri, University of Florence - Italy
  • Marco A. Cassatella, University of Verona - Italy
  • Hiroshi Matsuda, Tokyo University of Agriculture and Technology - Japan
  • Akane Tanaka, Tokyo University of Agriculture and Technology - Japan
  • Ronald Van Ree, Academic Medical Centre Amsterdam - Netherlands
  • Roy Gerth Van Wijk, Erasmus University Rotterdam - Netherlands
  • Rob C. Aalberse, Sanquin Blood Supply Foundation - Netherlands
  • André C. Knulst, Universiteit Utrecht - Netherlands
  • Maria Yazdanbakhsh, Leiden University Medical Center - Netherlands
  • Aud Katrine Herland Berstad, University of Bergen - Norway
  • Marek Jutel, Wroclaw Medical University - Poland
  • Mihaela Zidarn, Klinika Golnik - Slovenia
  • Peter Korosec, Klinika Golnik - Slovenia
  • Montserrat Fernandez-Rivas, Hospital Clinico San Carlos - Spain
  • Rosalia Rodriguez, Universidad Complutense de Madrid - Spain
  • Luis Fernandez Pacios, Universidad Politecnica de Madrid - Spain
  • Araceli Diaz-Perales, Universidad Politécnica de Madrid - Spain
  • Mats Ohlin, Lund University - Sweden
  • Marit Westman, Karolinska University Hospital - Sweden
  • Marianne Van Hage, Karolinska University Hospital - Sweden
  • Hans Grönlund, Karolinska University Hospital - Sweden
  • Gunnar Lilja, Karolinska Institutet - Sweden
  • Gunilla Hedlin, Karolinska Institutet - Sweden
  • Annika Scheynius, Karolinska Institute and Hospital - Sweden
  • Magnus Wickman, Karolinska Institutet - Sweden
  • Alexander Eggel, Inselspital Bern - Switzerland
  • Claudio Rhyner, Schweizerisches Institut für Allergie- und Asthmaforschung - Switzerland
  • Mübeccel Akdis, Schweizerisches Institut für Allergie- und Asthmaforschung - Switzerland
  • Eliane Marti, University of Bern - Switzerland
  • Cezmi A. Akdis, University of Zurich - Switzerland
  • Barbara K. Ballmer-Weber, Universitätsspital Zürich - Switzerland
  • Wladek Minor, University of Virginia - USA
  • Edward F. Rosloniec, University of Tennessee - USA
  • Enrique Fernandez-Caldas, University of South Florida College of Medicine - USA
  • Cem Akin, University of Michigan - USA
  • Soheila J. Maleki, United States Department of Agriculture - USA
  • Theodore S. Jardetzky, Stanford University School of Medicine - USA
  • Maksymilian Chruszcz, Michigan State University - USA
  • Ric Van Tol, Mead Johnson Nutrition - USA
  • Wayne Shreffler, Massachusetts General Hospital - USA
  • Facundo D. Batista, Harvard University - USA
  • Brian Seed, Harvard Medical School Massachusetts General Hospital - USA
  • Diane Mathis, Harvard Medical School - USA
  • Kenneth Roux, Florida State University - USA
  • Udo Herz, Mead Johnson Nutrition - USA
  • Marcos Alcocer, University of Nottingham
  • Nikolaos G. Papadopoulos, University of Manchester
  • Elisabeth N. Clare Mills, University of Manchester
  • Rick M. Maizels, University of Glasgow
  • Hannah J. Gould, King´s College London
  • Stephen R. Durham, Imperial College School of Medicine
  • Stephen T. Holgate, University of Southampton
  • Elopy Sibanda, University of Zimbabwe - Zimbabwe

Research Output

  • 31861 Citations
  • 520 Publications
Publications
  • 2021
    Title IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer
    DOI 10.1080/2162402x.2021.1880687
    Type Journal Article
    Author Jordakieva G
    Journal OncoImmunology
    Pages 1880687
    Link Publication
  • 2019
    Title Country-wide medical records infer increased allergy risk of gastric acid inhibition
    DOI 10.1038/s41467-019-10914-6
    Type Journal Article
    Author Jordakieva G
    Journal Nature Communications
    Pages 3298
    Link Publication
  • 2019
    Title A hypoallergenic peptide mix containing T cell epitopes of the clinically relevant house dust mite allergens
    DOI 10.1111/all.13956
    Type Journal Article
    Author Huang H
    Journal Allergy
    Pages 2461-2478
    Link Publication
  • 2019
    Title Epitope mapping of antibodies induced with a conserved rhinovirus protein generating protective anti-rhinovirus immunity
    DOI 10.1016/j.vaccine.2019.04.018
    Type Journal Article
    Author Sam Narean J
    Journal Vaccine
    Pages 2805-2813
    Link Publication
  • 2019
    Title Clinical and immunological differences between asymptomatic HDM-sensitized and HDM-allergic rhinitis patients
    DOI 10.1111/cea.13361
    Type Journal Article
    Author Zidarn M
    Journal Clinical & Experimental Allergy
    Pages 808-818
    Link Publication
  • 2019
    Title Evidence for a Role of TGF-ß-Activated Kinase 1 and MAP3K7 Binding Protein 3 in Peanut-Specific T-Cell Responses
    DOI 10.1159/000496438
    Type Journal Article
    Author Saidova A
    Journal International Archives of Allergy and Immunology
    Pages 10-16
  • 2019
    Title Gender aspects in food allergy.
    DOI 10.1097/aci.0000000000000529
    Type Journal Article
    Author Pali-Schöll I
    Journal Current opinion in allergy and clinical immunology
    Pages 249-255
  • 2019
    Title Fusion proteins consisting of Bet v 1 and Phl p 5 form IgE-reactive aggregates with reduced allergenic activity
    DOI 10.1038/s41598-019-39798-8
    Type Journal Article
    Author Najafi N
    Journal Scientific Reports
    Pages 4006
    Link Publication
  • 2019
    Title Preventive sublingual immunotherapy with House Dust Mite extract modulates epitope diversity in pre-school children
    DOI 10.1111/all.13658
    Type Journal Article
    Author Ponce M
    Journal Allergy
    Pages 780-787
    Link Publication
  • 2019
    Title Association between asthma, rhinitis, and conjunctivitis multimorbidities with molecular IgE sensitization in adults
    DOI 10.1111/all.13676
    Type Journal Article
    Author Siroux V
    Journal Allergy
    Pages 824-827
  • 2021
    Title Micronutritional supplementation with a holoBLG-based FSMP (food for special medical purposes)-lozenge alleviates allergic symptoms in BALB/c mice: Imitating the protective farm effect
    DOI 10.1111/cea.14050
    Type Journal Article
    Author Afify S
    Journal Clinical & Experimental Allergy
    Pages 426-441
    Link Publication
  • 2021
    Title Bovine Holo-Beta-Lactoglobulin Cross-Protects Against Pollen Allergies in an Innate Manner in BALB/c Mice: Potential Model for the Farm Effect
    DOI 10.3389/fimmu.2021.611474
    Type Journal Article
    Author Afify S
    Journal Frontiers in Immunology
    Pages 611474
    Link Publication
  • 2022
    Title Comprehensive Analysis of Nasal Polyps Reveals a More Pronounced Type 2 Transcriptomic Profile of Epithelial Cells and Mast Cells in Aspirin-Exacerbated Respiratory Disease
    DOI 10.3389/fimmu.2022.850494
    Type Journal Article
    Author Bangert C
    Journal Frontiers in Immunology
    Pages 850494
    Link Publication
  • 2022
    Title Secretory protein beta-lactoglobulin in cattle stable dust may contribute to the allergy-protective farm effect
    DOI 10.1002/clt2.12125
    Type Journal Article
    Author Pali-Schöll I
    Journal Clinical and Translational Allergy
    Link Publication
  • 2019
    Title Edible insects: Cross-recognition of IgE from crustacean- and house dust mite allergic patients, and reduction of allergenicity by food processing
    DOI 10.1016/j.waojou.2018.10.001
    Type Journal Article
    Author Pali-Schöll I
    Journal World Allergy Organization Journal
    Pages 100006
    Link Publication
  • 2019
    Title Sweet and CRISP(R)y parasite engineering
    DOI 10.1074/jbc.h118.007210
    Type Journal Article
    Author Wilson I
    Journal Journal of Biological Chemistry
    Pages 1126-1127
    Link Publication
  • 2019
    Title EAACI position paper: Comparing insect hypersensitivity induced by bite, sting, inhalation or ingestion in human beings and animals
    DOI 10.1111/all.13722
    Type Journal Article
    Author Pali-Schöll I
    Journal Allergy
    Pages 874-887
    Link Publication
  • 2019
    Title Prioritizing research challenges and funding for allergy and asthma and the need for translational research—The European Strategic Forum on Allergic Diseases
    DOI 10.1111/all.13856
    Type Journal Article
    Author Agache I
    Journal Allergy
    Pages 2064-2076
    Link Publication
  • 2019
    Title Recombinant allergens for immunotherapy: state of the art
    DOI 10.1097/aci.0000000000000536
    Type Journal Article
    Author Zhernov Y
    Journal Current Opinion in Allergy and Clinical Immunology
    Pages 402-414
    Link Publication
  • 2019
    Title Bet v 1-specific IgE levels and PR-10 reactivity discriminate silent sensitization from phenotypes of birch allergy
    DOI 10.1111/all.13931
    Type Journal Article
    Author Elisyutina O
    Journal Allergy
    Pages 2525-2528
    Link Publication
  • 2019
    Title Rational design of a hypoallergenic Phl p 7 variant for immunotherapy of polcalcin-sensitized patients
    DOI 10.1038/s41598-019-44208-0
    Type Journal Article
    Author Raith M
    Journal Scientific Reports
    Pages 7802
    Link Publication
  • 2019
    Title Generation of a Jurkat-based fluorescent reporter cell line to evaluate lipid antigen interaction with the human iNKT cell receptor
    DOI 10.1038/s41598-019-43529-4
    Type Journal Article
    Author Humeniuk P
    Journal Scientific Reports
    Pages 7426
    Link Publication
  • 2019
    Title EAACI position paper: Influence of dietary fatty acids on asthma, food allergy, and atopic dermatitis
    DOI 10.1111/all.13764
    Type Journal Article
    Author Venter C
    Journal Allergy
    Pages 1429-1444
    Link Publication
  • 2019
    Title Real-life safety of 5-grass pollen tablet in 5-to-9-year-old children with allergic rhinoconjunctivitis
    DOI 10.1016/j.anai.2019.04.011
    Type Journal Article
    Author Gerstlauer M
    Journal Annals of Allergy, Asthma & Immunology
    Pages 70-80
  • 2019
    Title Non-Oxidative Enzymatic (De)Carboxylation of (Hetero)Aromatics and Acrylic Acid Derivatives
    DOI 10.1002/adsc.201900275
    Type Journal Article
    Author Payer S
    Journal Advanced Synthesis & Catalysis
    Pages 2402-2420
    Link Publication
  • 2019
    Title Optimal control and the value of information for a stochastic epidemiological SIS-model
    DOI 10.1016/j.jmaa.2019.04.005
    Type Journal Article
    Author Grandits P
    Journal Journal of Mathematical Analysis and Applications
    Pages 665-695
    Link Publication
  • 2019
    Title Der p 23: Clinical Relevance of Molecular Monosensitization in House Dust Mite Allergy.
    DOI 10.18176/jiaci.0392
    Type Journal Article
    Author Matos Semedo F
    Journal Journal of investigational allergology & clinical immunology
    Pages 314-316
    Link Publication
  • 2018
    Title Selection of house dust mite–allergic patients by molecular diagnosis may enhance success of specific immunotherapy
    DOI 10.1016/j.jaci.2018.10.048
    Type Journal Article
    Author Chen K
    Journal Journal of Allergy and Clinical Immunology
    Link Publication
  • 2018
    Title Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy
    DOI 10.1016/j.jaci.2018.10.039
    Type Journal Article
    Author Bublin M
    Journal Journal of Allergy and Clinical Immunology
  • 2018
    Title IgG4 drives M2a macrophages to a regulatory M2b-like phenotype: potential implication in immune tolerance
    DOI 10.1111/all.13635
    Type Journal Article
    Author Bianchini R
    Journal Allergy
    Pages 483-494
    Link Publication
  • 2018
    Title Does a carrot a day keep the allergy away?
    DOI 10.1016/j.imlet.2018.10.009
    Type Journal Article
    Author Hufnagl K
    Journal Immunology Letters
    Pages 54-58
  • 2018
    Title Neutrophils promote T-cell–mediated inflammation in allergy
    DOI 10.1016/j.jaci.2018.11.035
    Type Journal Article
    Author Polak D
    Journal Journal of Allergy and Clinical Immunology
  • 2018
    Title Histamine causes influx via T-type voltage-gated calcium channels in an enterochromaffin tumor cell line: potential therapeutic target in adverse food reactions
    DOI 10.1152/ajpgi.00261.2018
    Type Journal Article
    Author Pfanzagl B
    Journal American Journal of Physiology-Gastrointestinal and Liver Physiology
    Link Publication
  • 2018
    Title Nicht-Zöliakie-Gluten-/Weizen-Sensitivität (NCGS) – ein bislang nicht definiertes Krankheitsbild mit fehlenden Diagnosekriterien und unbekannter Häufigkeit
    DOI 10.1055/a-0749-5278
    Type Journal Article
    Author Reese I
    Journal Aktuelle Ernährungsmedizin
    Pages 479-483
  • 2018
    Title Allergen immunotherapy in people, dogs, cats and horses – differences, similarities and research needs
    DOI 10.1111/all.13464
    Type Journal Article
    Author Mueller R
    Journal Allergy
    Pages 1989-1999
    Link Publication
  • 2018
    Title Allergic patients with and without allergen-specific immunotherapy mount protective immune responses to tick-borne encephalitis vaccination in absence of enhanced side effects or propagation of their Th2 bias
    DOI 10.1016/j.vaccine.2018.03.076
    Type Journal Article
    Author Garner-Spitzer E
    Journal Vaccine
    Pages 2816-2824
  • 2018
    Title Tree nut allergens
    DOI 10.1016/j.molimm.2018.03.011
    Type Journal Article
    Author Geiselhart S
    Journal Molecular Immunology
    Pages 71-81
    Link Publication
  • 2018
    Title Kurzfassung zur allergenspezifischen Immuntherapie bei IgE-vermittelten Erkrankungen im Kindes- und Jugendalter
    DOI 10.1007/s00112-018-0478-2
    Type Journal Article
    Author Szépfalusi Z
    Journal Monatsschrift Kinderheilkunde
    Pages 521-528
    Link Publication
  • 2018
    Title Non-celiac gluten/wheat sensitivity (NCGS)—a currently undefined disorder without validated diagnostic criteria and of unknown prevalence
    DOI 10.1007/s40629-018-0070-2
    Type Journal Article
    Author Reese I
    Journal Allergo Journal International
    Pages 147-151
    Link Publication
  • 2018
    Title Asymmetric Synthesis of (R)-1-Alkyl-Substituted Tetrahydro-ß-carbolines Catalyzed by Strictosidine Synthases
    DOI 10.1002/anie.201803372
    Type Journal Article
    Author Pressnitz D
    Journal Angewandte Chemie International Edition
    Pages 10683-10687
    Link Publication
  • 2018
    Title Ragweed Pollen Allergy: Burden, Characteristics, and Management of an Imported Allergen Source in Europe
    DOI 10.1159/000487997
    Type Journal Article
    Author Chen K
    Journal International Archives of Allergy and Immunology
    Pages 163-180
  • 2018
    Title C-H Activation Enables a Concise Total Synthesis of Quinine and Analogues with Enhanced Antimalarial Activity
    DOI 10.1002/anie.201804551
    Type Journal Article
    Author Donovan D
    Journal Angewandte Chemie International Edition
    Pages 10737-10741
    Link Publication
  • 2018
    Title Dysregulated invertebrate tropomyosin–dectin-1 interaction confers susceptibility to allergic diseases
    DOI 10.1126/sciimmunol.aam9841
    Type Journal Article
    Author Gour N
    Journal Science Immunology
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  • 2018
    Title Vitamin A and D in allergy: from experimental animal models and cellular studies to human disease
    DOI 10.1007/s40629-018-0054-2
    Type Journal Article
    Author Hufnagl K
    Journal Allergo Journal International
    Pages 72-78
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  • 2018
    Title Canine macrophages can like human macrophages be in vitro activated toward the M2a subtype relevant in allergy
    DOI 10.1016/j.dci.2018.01.005
    Type Journal Article
    Author Herrmann I
    Journal Developmental & Comparative Immunology
    Pages 118-127
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    Title Similar localization of conformational IgE epitopes on the house dust mite allergens Der p 5 and Der p 21 despite limited IgE cross-reactivity
    DOI 10.1111/all.13398
    Type Journal Article
    Author Curin M
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    Title Proposed Diagnostic Criteria and Classification of Canine Mast Cell Neoplasms: A Consensus Proposal
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    Title An Engineered Hybrid Protein from Dermatophagoides pteronyssinus Allergens Shows Hypoallergenicity
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    Title Molecular Approaches for Diagnosis, Therapy and Prevention of Cow´s Milk Allergy
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    Title National Institutes of Health–Defined Chronic Graft-vs.-Host Disease in Pediatric Hematopoietic Stem Cell Transplantation Patients Correlates With Parameters of Long-Term Immune Reconstitution
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    Title Debates in allergy medicine: Molecular allergy diagnosis with ISAC will replace screenings by skin prick test in the future
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    Title MEF2C-dysregulated pediatric T-cell acute lymphoblastic leukemia is associated with CDKN1B deletions and a poor response to glucocorticoid therapy
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    Title Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
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    Title T Cell Epitope-Containing Domains of Ragweed Amb a 1 and Mugwort Art v 6 Modulate Immunologic Responses in Humans and Mice
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    Title A B Cell Epitope Peptide Derived from the Major Grass Pollen Allergen Phl p 1 Boosts Allergen-Specific Secondary Antibody Responses without Allergen-Specific T Cell Help
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    Title Surgical Elimination of the Gastric Digestion by Roux-en-Y Gastric Bypass Impacts on Food Sensitisation—a Pilot Study
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    Title Traditional Formula, Modern Application: Chinese Medicine Formula Sini Tang Improves Early Ventricular Remodeling and Cardiac Function after Myocardial Infarction in Rats
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    Title Transmission of allergen-specific IgG and IgE from maternal blood into breast milk visualized with microarray technology
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    Type Journal Article
    Author Hochwallner H
    Journal Journal of Allergy and Clinical Immunology
    Pages 1213-1215
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  • 2014
    Title IgE, IgG4 and IgA specific to Bet v 1-related food allergens do not predict oral allergy syndrome
    DOI 10.1111/all.12534
    Type Journal Article
    Author Guhsl E
    Journal Allergy
    Pages 59-66
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  • 2014
    Title Prophylactic and therapeutic vaccination with carrier-bound Bet v 1 peptides lacking allergen-specific T cell epitopes reduces Bet v 1-specific T cell responses via blocking antibodies in a murine model for birch pollen allergy
    DOI 10.1111/cea.12216
    Type Journal Article
    Author Linhart B
    Journal Clinical & Experimental Allergy
    Pages 278-287
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  • 2014
    Title Chimeras of Bet v 1 and Api g 1 reveal heterogeneous IgE responses in patients with birch pollen allergy
    DOI 10.1016/j.jaci.2013.12.1073
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    Author Gepp B
    Journal Journal of Allergy and Clinical Immunology
    Pages 188-194
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  • 2014
    Title Multiple independent IgE epitopes on the highly allergenic grass pollen allergen Phl p 5
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    Type Journal Article
    Author Levin M
    Journal Clinical & Experimental Allergy
    Pages 1409-1419
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  • 2014
    Title Peripheral Erythrocytes Decrease upon Specific Respiratory Challenge with Grass Pollen Allergen in Sensitized Mice and in Human Subjects
    DOI 10.1371/journal.pone.0086701
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    Author Jordakieva G
    Journal PLoS ONE
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  • 2014
    Title Allergic sensitization: screening methods
    DOI 10.1186/2045-7022-4-13
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    Author Ladics G
    Journal Clinical and Translational Allergy
    Pages 13-13
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  • 2014
    Title Identification of Ponatinib as a potent inhibitor of growth, migration, and activation of neoplastic eosinophils carrying FIP1L1-PDGFRA
    DOI 10.1016/j.exphem.2013.12.007
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    Author Sadovnik I
    Journal Experimental Hematology
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  • 2014
    Title Cytokine Effects Induced by the Human Autoallergen a-NAC
    DOI 10.1038/jid.2014.25
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    Author Hradetzky S
    Journal Journal of Investigative Dermatology
    Pages 1570-1578
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  • 2014
    Title The serum tryptase test: an emerging robust biomarker in clinical hematology
    DOI 10.1586/17474086.2014.955008
    Type Journal Article
    Author Valent P
    Journal Expert Review of Hematology
    Pages 683-690
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  • 2014
    Title A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection
    DOI 10.1182/blood-2013-10-534685
    Type Journal Article
    Author Saleh R
    Journal Blood
    Pages 111-120
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    Title Birth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop
    DOI 10.1016/j.jaci.2014.01.018
    Type Journal Article
    Author Bousquet J
    Journal Journal of Allergy and Clinical Immunology
    Pages 1535-1546
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  • 2014
    Title Disease Patterns in the Presence of Histamine Intolerance
    DOI 10.1007/978-3-642-55447-6_3
    Type Book Chapter
    Author Götz M
    Publisher Springer Nature
    Pages 45-95
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    Title Geographic and temporal variations in pollen exposure across Europe
    DOI 10.1111/all.12419
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    Author Smith M
    Journal Allergy
    Pages 913-923
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  • 2014
    Title Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal
    DOI 10.1093/annonc/mdu047
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    Author Valent P
    Journal Annals of Oncology
    Pages 1691-1700
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  • 2014
    Title 10th anniversary of the Austrian MDS Platform: aims and ongoing projects
    DOI 10.1007/s00508-014-0627-0
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    Author Burgstaller S
    Journal Wiener klinische Wochenschrift
    Pages 12-15
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    Title Role of IgE in Disease
    DOI 10.1007/978-1-4614-9194-1_79
    Type Book Chapter
    Author Szépfalusi Z
    Publisher Springer Nature
    Pages 601-606
  • 2014
    Title Happy 25th birthday, Bet v 1!
    DOI 10.1186/1939-4551-7-14
    Type Journal Article
    Author Jensen-Jarolim E
    Journal World Allergy Organization Journal
    Pages 14
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  • 2014
    Title Development and characterization of a recombinant, hypoallergenic, peptide-based vaccine for grass pollen allergy
    DOI 10.1016/j.jaci.2014.09.012
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    Author Focke-Tejkl M
    Journal Journal of Allergy and Clinical Immunology
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  • 2014
    Title Lymphocyte-Based Model Systems for Allergy Research: A Historic Overview
    DOI 10.1159/000360163
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    Author Neunkirchner A
    Journal International Archives of Allergy and Immunology
    Pages 259-291
  • 2014
    Title HLA class II peptide tetramers vs allergen-induced proliferation for identification of allergen-specific CD4 T cells
    DOI 10.1111/all.12524
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    Author Van Hemelen D
    Journal Allergy
    Pages 49-58
  • 2014
    Title Microarrayed dog, cat, and horse allergens show weak correlation between allergen-specific IgE and IgG responses?
    DOI 10.1016/j.jaci.2013.10.058
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    Author Curin M
    Journal Journal of Allergy and Clinical Immunology
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  • 2014
    Title Primary prevention of food allergy in children and adults: systematic review
    DOI 10.1111/all.12334
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    Author De Silva D
    Journal Allergy
    Pages 581-589
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  • 2014
    Title Clustering of comorbidities is related to age and sex and impacts clinical outcome in myelodysplastic syndromes
    DOI 10.1016/j.jgo.2014.02.002
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    Author Bammer C
    Journal Journal of Geriatric Oncology
    Pages 299-306
  • 2014
    Title EAACI Food Allergy and Anaphylaxis Guidelines: diagnosis and management of food allergy
    DOI 10.1111/all.12429
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    Author Muraro A
    Journal Allergy
    Pages 1008-1025
  • 2014
    Title Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences
    DOI 10.1111/all.12348
    Type Journal Article
    Author Radauer C
    Journal Allergy
    Pages 413-419
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  • 2011
    Title Provoking allergens and treatment of anaphylaxis in children and adolescents – data from the anaphylaxis registry of German-speaking countries
    DOI 10.1111/j.1399-3038.2011.01154.x
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    Author Hompes S
    Journal Pediatric Allergy and Immunology
    Pages 568-574
  • 2011
    Title Boiling peanut Ara h 1 results in the formation of aggregates with reduced allergenicity
    DOI 10.1002/mnfr.201100251
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    Author Blanc F
    Journal Molecular Nutrition & Food Research
    Pages 1887-1894
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  • 2011
    Title Definitions, Criteria and Global Classification of Mast Cell Disorders with Special Reference to Mast Cell Activation Syndromes: A Consensus Proposal
    DOI 10.1159/000328760
    Type Journal Article
    Author Valent P
    Journal International Archives of Allergy and Immunology
    Pages 215-225
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  • 2011
    Title Misdirected antibody responses against an N-terminal epitope on human rhinovirus VP1 as explanation for recurrent RV infections
    DOI 10.1096/fj.11-193557
    Type Journal Article
    Author Niespodziana K
    Journal The FASEB Journal
    Pages 1001-1008
  • 2011
    Title Sphingosine-kinase 1 and 2 contribute to oral sensitization and effector phase in a mouse model of food allergy
    DOI 10.1016/j.imlet.2011.10.006
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    Author Diesner S
    Journal Immunology Letters
    Pages 210-219
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  • 2011
    Title Nilotinib as frontline and second-line therapy in chronic myeloid leukemia: Open questions
    DOI 10.1016/j.critrevonc.2011.08.002
    Type Journal Article
    Author Valent P
    Journal Critical Reviews in Oncology/Hematology
    Pages 370-377
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  • 2011
    Title CD34+/CD38- stem cells in chronic myeloid leukemia express Siglec-3 (CD33) and are responsive to the CD33-targeting drug gemtuzumab/ozogamicin
    DOI 10.3324/haematol.2010.035006
    Type Journal Article
    Author Herrmann H
    Journal Haematologica
    Pages 219-226
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  • 2011
    Title Effect of Heating and Glycation on the Allergenicity of 2S Albumins (Ara h 2/6) from Peanut
    DOI 10.1371/journal.pone.0023998
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    Author Vissers Y
    Journal PLoS ONE
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  • 2010
    Title The multinational birth cohort of EuroPrevall: background, aims and methods
    DOI 10.1111/j.1398-9995.2009.02171.x
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    Author Keil T
    Journal Allergy
    Pages 482-490
  • 2013
    Title Recombinant house dust mite allergens
    DOI 10.1016/j.ymeth.2013.07.034
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    Author Vrtala S
    Journal Methods
    Pages 67-74
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  • 2013
    Title A WAO - ARIA - GA²LEN consensus document on molecular-based allergy diagnostics
    DOI 10.1186/1939-4551-6-17
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    Author Canonica G
    Journal World Allergy Organization Journal
    Pages 17
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  • 2013
    Title The diagnosis of food allergy: protocol for a systematic review
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    Author Soares-Weiser K
    Journal Clinical and Translational Allergy
    Pages 18-18
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  • 2013
    Title Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross-reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients’ sera
    DOI 10.1002/mnfr.201300153
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    Author Guhsl E
    Journal Molecular Nutrition & Food Research
    Pages 625-634
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  • 2013
    Title IgE cross-reactivity between the major peanut allergen Ara h 2 and the nonhomologous allergens Ara h 1 and Ara h 3
    DOI 10.1016/j.jaci.2013.01.022
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    Author Bublin M
    Journal Journal of Allergy and Clinical Immunology
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  • 2013
    Title Proposed score for survival of patients with myelodysplastic syndromes
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    Journal European Journal of Clinical Investigation
    Pages 1120-1128
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    Title Oncostatin M is a FIP1L1/PDGFRA-dependent mediator of cytokine production in chronic eosinophilic leukemia
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    Author Hoermann G
    Journal Allergy
    Pages 713-723
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    Title Possible therapeutic potential of a recombinant group 2 grass pollen allergen-specific antibody fragment
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    Author Gadermaier E
    Journal Allergy
    Pages 261-264
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  • 2013
    Title Definition of Comparative Medicine: History and New Identity
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    Author Jensen-Jarolim E
    Publisher Springer Nature
    Pages 1-18
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    Title Identification of a Homozygous PSTPIP1 Mutation in a Patient With a PAPA-Like Syndrome Responding to Canakinumab Treatment
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    Author Geusau A
    Journal JAMA Dermatology
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    Title Eosinophilic gastrointestinal disease suggestive of pathogenesis-related class 10 (PR-10) protein allergy resolved after immunotherapy
    DOI 10.1016/j.jaci.2012.10.057
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    Author De Swert L
    Journal Journal of Allergy and Clinical Immunology
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  • 2013
    Title A Th17- and Th2-skewed Cytokine Profile in Cystic Fibrosis Lungs Represents a Potential Risk Factor for Pseudomonas aeruginosa Infection
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    Author Tiringer K
    Journal American journal of respiratory and critical care medicine
    Pages 621-629
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    Title Advances in allergen-microarray technology for diagnosis and monitoring of allergy: The MeDALL allergen-chip
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    Journal Methods
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  • 2013
    Title Comprehensive mutational profiling in advanced systemic mastocytosis
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    Author Schwaab J
    Journal Blood
    Pages 2460-2466
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    Title The epidemiology of food allergy in Europe: protocol for a systematic review
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    Journal Clinical and Translational Allergy
    Pages 13-13
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  • 2013
    Title E- and P-Selectins Are Essential for Repopulation of Chronic Myelogenous and Chronic Eosinophilic Leukemias in a Scid Mouse Xenograft Model
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    Author Wicklein D
    Journal PLoS ONE
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  • 2013
    Title A novel concept for detoxification: Complexation between aconitine and liquiritin in a Chinese herbal formula (‘Sini Tang’)
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    Author Peter K
    Journal Journal of Ethnopharmacology
    Pages 562-569
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    Title Structure of allergens and structure based epitope predictions
    DOI 10.1016/j.ymeth.2013.07.024
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    Author Dall’Antonia F
    Journal Methods
    Pages 3-21
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    Title Recombinant Mal d 1 is a reliable diagnostic tool for birch pollen allergen–associated apple allergy
    DOI 10.1016/j.jaci.2013.05.030
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    Author Kollmann D
    Journal Journal of Allergy and Clinical Immunology
    Pages 1008-1010
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    Title Structural and bioinformatic analysis of the kiwifruit allergen Act d 11, a member of the family of ripening-related proteins
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    Author Chruszcz M
    Journal Molecular Immunology
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    Title Acute and long-term management of food allergy: systematic review
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    Author De Silva D
    Journal Allergy
    Pages 159-167
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    Title IgE versus IgG4 epitopes of the peanut allergen Ara h 1 in patients with severe allergy
    DOI 10.1016/j.molimm.2013.11.014
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    Journal Molecular Immunology
    Pages 169-176
  • 2013
    Title Heterogeneity of Neoplastic Stem Cells: Theoretical, Functional, and Clinical Implications
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    Author Valent P
    Journal Cancer Research
    Pages 1037-1045
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  • 2013
    Title What Is the Source of Serum Allergen-Specific IgE?
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    Author Eckl-Dorna J
    Journal Current Allergy and Asthma Reports
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    Title Cloning, expression in E. coli and immunological characterization of Par j 3.0201, a Parietaria pollen profilin variant
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    Author Bonura A
    Journal Molecular Immunology
    Pages 220-225
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    Title Molecular chimerism in IgE-mediated allergy
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    Journal Chimerism
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    Title Long-term follow-up after allogeneic stem cell transplantation in patients with myelodysplastic syndromes or secondary acute myeloid leukemia: a single center experience
    DOI 10.1007/s00508-013-0449-5
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    Journal Wiener klinische Wochenschrift
    Pages 23-29
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    Title Recombinant allergen-based provocation testing
    DOI 10.1016/j.ymeth.2013.07.037
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    Author Niederberger V
    Journal Methods
    Pages 96-105
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  • 2013
    Title Prognosis of acute myeloid leukemia transformed from myelodysplastic syndromes: A multicenter retrospective study
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    Author Okuyama N
    Journal Leukemia Research
    Pages 862-867
  • 2013
    Title The acute and long-term management of food allergy: protocol for a rapid systematic review
    DOI 10.1186/2045-7022-3-12
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    Author De Silva D
    Journal Clinical and Translational Allergy
    Pages 12-12
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  • 2013
    Title Allergen microarray detects high prevalence of asymptomatic IgE sensitizations to tropical pollen-derived carbohydrates
    DOI 10.1016/j.jaci.2013.10.004
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    Author Cabauatan C
    Journal Journal of Allergy and Clinical Immunology
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  • 2013
    Title Oesophagostomum dentatum Extract Modulates T Cell-Dependent Immune Responses to Bystander Antigens and Prevents the Development of Allergy in Mice
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    Author Schabussova I
    Journal PLoS ONE
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  • 2013
    Title Crystal structure and immunologic characterization of the major grass pollen allergen Phl p 4
    DOI 10.1016/j.jaci.2013.03.021
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    Author Zafred D
    Journal Journal of Allergy and Clinical Immunology
  • 2013
    Title The Human IgE Repertoire
    DOI 10.1159/000355947
    Type Journal Article
    Author Gadermaier E
    Journal International Archives of Allergy and Immunology
    Pages 77-91
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  • 2013
    Title Dissection of the IgE and T-cell recognition of the major group 5 grass pollen allergen Phl p 5
    DOI 10.1016/j.jaci.2013.08.038
    Type Journal Article
    Author Focke-Tejkl M
    Journal Journal of Allergy and Clinical Immunology
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