Evolutionary analysis of gene regulation

Evolutionary analysis of gene regulation

Calin Guet (ORCID: 0000-0001-6220-2052)

Bilaterale Ausschreibung: Russland

Disciplines

Biology (100%)

Keywords

    Fitness landscape, Genomics, Evolution, Bacterial Gene Regulation, Experimental Evolution

Abstract

Genes are governed by the cell machinery in complicated ways. Our project aims to understand some of the complexity of gene regulation by playing around with one of the key signals that regulates the usage of a specific gene. To achieve this goal, we will use an in-house tool to grow bacteria and to test how changes in the genetic makeup of the regulator of one gene influence bacterial growth. This work will help us understand how gene regulation works and evolves in bacteria.
Research institution(s)
Project participants
International project participants

Research Output

  • 16 Citations
  • 3 Publications
Publications
  • 2022
    Title Extended family with an inherited pathogenic variant in polymerase delta provides strong evidence for recessive effect of proofreading deficiency in human cells
    DOI 10.1101/2022.07.20.500591
    Type Preprint
    Author Andrianova M
    Pages 2022.07.20.500591
    Link Publication
  • 2022
    Title Relation Between the Number of Peaks and the Number of Reciprocal Sign Epistatic Interactions
    DOI 10.1007/s11538-022-01029-z
    Type Journal Article
    Author Saona R
    Journal Bulletin of Mathematical Biology
    Pages 74
    Link Publication
  • 2022
    Title Chromosome-encoded IpaH ubiquitin ligases indicate non-human enteroinvasive Escherichia
    DOI 10.1038/s41598-022-10827-3
    Type Journal Article
    Author Dranenko N
    Journal Scientific Reports
    Pages 6868
    Link Publication