Structure based molecular design of HIV-1 integrase inhibitors

Structure based molecular design of HIV-1 integrase inhibitors

Christoph Sotriffer (ORCID: )

Disciplines

Chemistry (50%); Medical-Theoretical Sciences, Pharmacy (50%)

Keywords

    AIDS, HIV INTEGRASE, DRUG DESIGN, DOCKING

Research institution(s)

Research Output

  • 659 Citations
  • 6 Publications
Publications
  • 2004
    Title Discovery of a Novel Binding Trench in HIV Integrase
    DOI 10.1021/jm0341913
    Type Journal Article
    Author Schames J
    Journal Journal of Medicinal Chemistry
    Pages 1879-1881
  • 2002
    Title Thalassiolins A–C: new marine-derived inhibitors of HIV cDNA integrase
    DOI 10.1016/s0968-0896(02)00241-9
    Type Journal Article
    Author Rowley D
    Journal Bioorganic & Medicinal Chemistry
    Pages 3619-3625
  • 2001
    Title Ordered Water and Ligand Mobility in the HIV-1 Integrase-5CITEP Complex: A Molecular Dynamics Study
    DOI 10.1021/jm010205y
    Type Journal Article
    Author Ni
    Journal Journal of Medicinal Chemistry
    Pages 3043-3047
  • 2000
    Title HIV-1 Integrase Inhibitor Interactions at the Active Site: Prediction of Binding Modes Unaffected by Crystal Packing
    DOI 10.1021/ja001152x
    Type Journal Article
    Author Sotriffer C
    Journal Journal of the American Chemical Society
    Pages 6136-6137
  • 2000
    Title Active Site Binding Modes of HIV-1 Integrase Inhibitors
    DOI 10.1021/jm000194t
    Type Journal Article
    Author Sotriffer C
    Journal Journal of Medicinal Chemistry
    Pages 4109-4117
  • 2000
    Title Elbow Flexibility and Ligand-Induced Domain Rearrangements in Antibody Fab NC6.8: Large Effects of a Small Hapten
    DOI 10.1016/s0006-3495(00)76320-x
    Type Journal Article
    Author Sotriffer C
    Journal Biophysical Journal
    Pages 614-628
    Link Publication