A Reference Model of Explainable AI for the Medical Domain
A Reference Model of Explainable AI for the Medical Domain
Disciplines
Computer Sciences (100%)
Keywords
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Explainable Ai
The progress of statistical machine learning methods has made Artificial Intelligence (AI) increasingly successful. Deep learning exceed human performance even in the medical domain. However, their full potential is limited by the difficulty to generate the underlying explanatory structures. The central problem is that they are regarded as black-boxes and even if we understand the mathematical principles, they lack an explicit declarative knowledge representation. This calls for tools enabling to make decisions transparent, understandable and explainable. A huge motivation for this project are rising legal and privacy issues, which make black-boxes difficult to use. This does not imply a ban on automatic learning approaches or an obligation to explain everything all the time, however, there must be a possibility to make the results re-traceable on demand. The topic of this project is explainability and our goal is to make existing AI/ML algorithms transparent, re- traceable, thus understandable to a medical professional and outline a possible new approach towards explainable AI. We learned of a variety of technical solutions which are currently in development, which could help explain AI/ML systems and their decisions. Transparent algorithms could appropriately enhance trust of medical professionals, thereby raising acceptance of machine learning solutions specifically and of AI generally. We will combine ML with a continuous input stream of sensoric data and (implicit) knowledge capturing thereby making use of human cognitive abilities. All outcomes of this project, algorithms and tools, will be made openly available to the international research community.
- Bastian Pfeifer, Medizinische Universität Graz , national collaboration partner
Research Output
- 4512 Citations
- 92 Publications
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2025
Title On the disagreement problem in Human-in-the-Loop federated machine learning DOI 10.1016/j.jii.2025.100827 Type Journal Article Author Huelser M Journal Journal of Industrial Information Integration Pages 100827 Link Publication -
2025
Title LLM in the Loop: A Framework for Contextualizing Counterfactual Segment Perturbations in Point Clouds DOI 10.1109/access.2025.3568052 Type Journal Article Author Kocic V Journal IEEE Access Pages 85507-85525 Link Publication -
2025
Title Tree smoothing: Post-hoc regularization of tree ensembles for interpretable machine learning DOI 10.1016/j.ins.2024.121564 Type Journal Article Author Pfeifer B Journal Information Sciences Pages 121564 Link Publication -
2025
Title Fine-tuning language model embeddings to reveal domain knowledge: An explainable artificial intelligence perspective on medical decision making DOI 10.1016/j.engappai.2024.109561 Type Journal Article Author Kraišnikovic C Journal Engineering Applications of Artificial Intelligence Pages 109561 Link Publication -
2025
Title Integrating Belief-Desire-Intention agents with large language models for reliable human–robot interaction and explainable Artificial Intelligence DOI 10.1016/j.engappai.2024.109771 Type Journal Article Author Frering L Journal Engineering Applications of Artificial Intelligence Pages 109771 Link Publication -
2025
Title Enhancing trust in automated 3D point cloud data interpretation through explainable counterfactuals DOI 10.1016/j.inffus.2025.103032 Type Journal Article Author Holzinger A Journal Information Fusion Pages 103032 Link Publication -
2025
Title Comparative performance of PD-L1 scoring by pathologists and AI algorithms DOI 10.1111/his.15432 Type Journal Article Author Plass M Journal Histopathology Link Publication -
2024
Title Artificial intelligence based data curation: enabling a patient-centric European health data space DOI 10.3389/fmed.2024.1365501 Type Journal Article Author De Zegher I Journal Frontiers in Medicine Pages 1365501 Link Publication -
2024
Title Multi-objective optimization of cable-road layouts in smart forestry DOI 10.1080/14942119.2024.2380229 Type Journal Article Author Retzlaff C Journal International Journal of Forest Engineering Pages 444-455 Link Publication -
2024
Title A Practical Tutorial on Explainable AI Techniques DOI 10.1145/3670685 Type Journal Article Author Bennetot A Journal ACM Computing Surveys Pages 1-44 Link Publication -
2024
Title Class imbalance in multi-resident activity recognition: an evaluative study on explainability of deep learning approaches DOI 10.1007/s10209-024-01123-0 Type Journal Article Author Singh D Journal Universal Access in the Information Society Pages 1-19 Link Publication -
2024
Title Usability in human-robot collaborative workspaces DOI 10.1007/s10209-024-01163-6 Type Journal Article Author Schraick L Journal Universal Access in the Information Society Pages 1-14 Link Publication -
2024
Title Is human oversight to AI systems still possible? DOI 10.1016/j.nbt.2024.12.003 Type Journal Article Author Holzinger A Journal New Biotechnology Pages 59-62 Link Publication -
2024
Title From Industry 5.0 to Forestry 5.0: Bridging the gap with Human-Centered Artificial Intelligence DOI 10.1007/s40725-024-00231-7 Type Journal Article Author Holzinger A Journal Current Forestry Reports Pages 442-455 Link Publication -
2024
Title Collaborative weighting in federated graph neural networks for disease classification with the human-in-the-loop DOI 10.1038/s41598-024-72748-7 Type Journal Article Author Hausleitner C Journal Scientific Reports Pages 21839 Link Publication -
2024
Title From 3D point-cloud data to explainable geometric deep learning: State-of-the-art and future challenges DOI 10.1002/widm.1554 Type Journal Article Author Saranti A Journal Wiley Interdisciplinary Reviews: Data Mining and Knowledge Discovery Link Publication -
2024
Title Ethical ChatGPT: Concerns, Challenges, and Commandments DOI 10.3390/electronics13173417 Type Journal Article Author Zhou J Journal Electronics Pages 3417 Link Publication -
2024
Title Explainable Artificial Intelligence (XAI) 2.0: A manifesto of open challenges and interdisciplinary research directions DOI 10.1016/j.inffus.2024.102301 Type Journal Article Author Longo L Journal Information Fusion Pages 102301 Link Publication -
2024
Title CLARUS: An interactive explainable AI platform for manual counterfactuals in graph neural networks DOI 10.1016/j.jbi.2024.104600 Type Journal Article Author Metsch J Journal Journal of Biomedical Informatics Pages 104600 Link Publication -
2024
Title Reviewing the essential roles of remote phenotyping, GWAS and explainable AI in practical marker-assisted selection for drought-tolerant winter wheat breeding DOI 10.3389/fpls.2024.1319938 Type Journal Article Author Chang-Brahim I Journal Frontiers in Plant Science Pages 1319938 Link Publication -
2024
Title Explainable Artificial Intelligence to Support Work Safety in Forestry: Insights from Two Large Datasets, Open Challenges, and Future Work DOI 10.3390/app14093911 Type Journal Article Author Hoenigsberger F Journal Applied Sciences Pages 3911 Link Publication -
2024
Title Post-hoc vs ante-hoc explanations: xAI design guidelines for data scientists DOI 10.1016/j.cogsys.2024.101243 Type Journal Article Author Retzlaff C Journal Cognitive Systems Research Pages 101243 Link Publication -
2024
Title Diffusion-based generation of Histopathological Whole Slide Images at a Gigapixel scale DOI 10.1109/wacv57701.2024.00505 Type Conference Proceeding Abstract Author Harb R Pages 5119-5128 Link Publication -
2024
Title Simulating cable corridors based on terrestrial LiDAR data DOI 10.1007/s10342-024-01673-1 Type Journal Article Author Retzlaff C Journal European Journal of Forest Research Pages 1083-1095 Link Publication -
2024
Title On generating trustworthy counterfactual explanations DOI 10.1016/j.ins.2023.119898 Type Journal Article Author Del Ser J Journal Information Sciences Pages 119898 Link Publication -
2024
Title Exploring artificial intelligence for applications of drones in forest ecology and management DOI 10.1016/j.foreco.2023.121530 Type Journal Article Author Buchelt A Journal Forest Ecology and Management Pages 121530 Link Publication -
2022
Title Information fusion as an integrative cross-cutting enabler to achieve robust, explainable, and trustworthy medical artificial intelligence DOI 10.1016/j.inffus.2021.10.007 Type Journal Article Author Holzinger A Journal Information Fusion Pages 263-278 Link Publication -
2022
Title GNN-SubNet: disease subnetwork detection with explainable Graph Neural Networks DOI 10.1101/2022.01.12.475995 Type Preprint Author Pfeifer B Pages 2022.01.12.475995 Link Publication -
2022
Title The explainability paradox: Challenges for xAI in digital pathology DOI 10.1016/j.future.2022.03.009 Type Journal Article Author Evans T Journal Future Generation Computer Systems Pages 281-296 Link Publication -
2022
Title State-of-the-Art Explainability Methods with Focus on Visual Analytics Showcased by Glioma Classification DOI 10.3390/biomedinformatics2010009 Type Journal Article Author Gashi M Journal BioMedInformatics Pages 139-158 Link Publication -
2022
Title Deep ROC Analysis and AUC as Balanced Average Accuracy, for Improved Classifier Selection, Audit and Explanation DOI 10.1109/tpami.2022.3145392 Type Journal Article Author Carrington A Journal IEEE Transactions on Pattern Analysis and Machine Intelligence Pages 329-341 Link Publication -
2022
Title Personas for Artificial Intelligence (AI) an Open Source Toolbox DOI 10.1109/access.2022.3154776 Type Journal Article Author Holzinger A Journal IEEE Access Pages 23732-23747 Link Publication -
2021
Title Classification by ordinal sums of conjunctive and disjunctive functions for explainable AI and interpretable machine learning solutions DOI 10.1016/j.knosys.2021.106916 Type Journal Article Author Hudec M Journal Knowledge-Based Systems Pages 106916 Link Publication -
2021
Title Evaluating the Quality of Machine Learning Explanations: A Survey on Methods and Metrics DOI 10.3390/electronics10050593 Type Journal Article Author Zhou J Journal Electronics Pages 593 Link Publication -
2021
Title Towards multi-modal causability with Graph Neural Networks enabling information fusion for explainable AI DOI 10.1016/j.inffus.2021.01.008 Type Journal Article Author Holzinger A Journal Information Fusion Pages 28-37 Link Publication -
2021
Title AI and Big Data in Healthcare: Towards a More Comprehensive Research Framework for Multimorbidity DOI 10.3390/jcm10040766 Type Journal Article Author Majnaric L Journal Journal of Clinical Medicine Pages 766 Link Publication -
2021
Title Towards Visual Concept Learning and Reasoning: On Insights into Representative Approaches DOI 10.1007/978-3-030-67148-8_5 Type Book Chapter Author Saranti A Publisher Springer Nature Pages 59-68 -
2021
Title The augmented radiologist: artificial intelligence in the practice of radiology DOI 10.1007/s00247-021-05177-7 Type Journal Article Author Sorantin E Journal Pediatric Radiology Pages 2074-2086 Link Publication -
2021
Title Toward HumanAI Interfaces to Support Explainability and Causability in Medical AI DOI 10.1109/mc.2021.3092610 Type Journal Article Author Holzinger A Journal Computer Pages 78-86 Link Publication -
2023
Title Ensemble-GNN: federated ensemble learning with graph neural networks for disease module discovery and classification DOI 10.1101/2023.03.22.533772 Type Preprint Author Pfeifer B Pages 2023.03.22.533772 Link Publication -
2023
Title AI for life: Trends in artificial intelligence for biotechnology DOI 10.1016/j.nbt.2023.02.001 Type Journal Article Author Holzinger A Journal New Biotechnology Pages 16-24 Link Publication -
2023
Title BIBBOX, a FAIR toolbox and App Store for life science research DOI 10.1016/j.nbt.2023.06.001 Type Journal Article Author Müller H Journal New Biotechnology Pages 12-19 Link Publication -
2023
Title Digital Transformation Needs Trustworthy Artificial Intelligence DOI 10.1016/j.mcpdig.2023.05.007 Type Journal Article Author Holzinger A Journal Mayo Clinic Proceedings: Digital Health Pages 296-298 Link Publication -
2023
Title Explainability and causability in digital pathology DOI 10.1002/cjp2.322 Type Journal Article Author Plass M Journal The Journal of Pathology: Clinical Research Pages 251-260 Link Publication -
2023
Title The Cost of Understanding—XAI Algorithms towards Sustainable ML in the View of Computational Cost DOI 10.3390/computation11050092 Type Journal Article Author Jean-Quartier C Journal Computation Pages 92 Link Publication -
2023
Title Quod erat demonstrandum? - Towards a typology of the concept of explanation for the design of explainable AI DOI 10.1016/j.eswa.2022.118888 Type Journal Article Author Cabitza F Journal Expert Systems with Applications Pages 118888 Link Publication -
2020
Title Classification and Visualization of Patterns in Medical Images DOI 10.1109/iv51561.2020.00110 Type Conference Proceeding Abstract Author Müller H Pages 639-643 -
2020
Title Reconstruct and Visualise Hierarchical Relationships in Whole Slide Images DOI 10.1109/iv51561.2020.00057 Type Conference Proceeding Abstract Author Plass M Pages 632-638 -
2020
Title Explainable AI and Multi-Modal Causability in Medicine DOI 10.1515/icom-2020-0024 Type Journal Article Author Holzinger A Journal i-com Pages 171-179 Link Publication -
2023
Title The underuse of AI in the health sector: Opportunity costs, success stories, risks and recommendations DOI 10.1007/s12553-023-00806-7 Type Journal Article Author Pagallo U Journal Health and Technology Pages 1-14 Link Publication -
2023
Title Ensemble-GNN: federated ensemble learning with graph neural networks for disease module discovery and classification DOI 10.1093/bioinformatics/btad703 Type Journal Article Author Pfeifer B Journal Bioinformatics Link Publication -
2023
Title Efficient Approximation of Asymmetric Shapley Values Using Functional Decomposition DOI 10.1007/978-3-031-40837-3_2 Type Book Chapter Author Gevaert A Publisher Springer Nature Pages 13-30 -
2023
Title Human-in-the-Loop Integration with Domain-Knowledge Graphs for Explainable Federated Deep Learning DOI 10.1007/978-3-031-40837-3_4 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 45-64 -
2023
Title Controllable AI - An Alternative to Trustworthiness in Complex AI Systems? DOI 10.1007/978-3-031-40837-3_1 Type Book Chapter Author Kieseberg P Publisher Springer Nature Pages 1-12 -
2023
Title The Tower of Babel in Explainable Artificial Intelligence (XAI) DOI 10.1007/978-3-031-40837-3_5 Type Book Chapter Author Schneeberger D Publisher Springer Nature Pages 65-81 Link Publication -
2023
Title Fair and equitable AI in biomedical research and healthcare: Social science perspectives DOI 10.1016/j.artmed.2023.102658 Type Journal Article Author Baumgartner R Journal Artificial Intelligence in Medicine Pages 102658 Link Publication -
2023
Title Toward human-level concept learning: Pattern benchmarking for AI algorithms DOI 10.1016/j.patter.2023.100788 Type Journal Article Author Holzinger A Journal Patterns Pages 100788 Link Publication -
2023
Title NarmViz: A novel method for visualization of time series numerical association rules for smart agriculture DOI 10.1111/exsy.13503 Type Journal Article Author Fister I Journal Expert Systems -
2023
Title Provenance of specimen and data – A prerequisite for AI development in computational pathology DOI 10.1016/j.nbt.2023.09.006 Type Journal Article Author Plass M Journal New Biotechnology Pages 22-28 Link Publication -
2021
Title The Next Frontier: AI We Can Really Trust DOI 10.1007/978-3-030-93736-2_33 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 427-440 -
2021
Title Towards a Taxonomy for Explainable AI in Computational Pathology DOI 10.1007/978-3-030-72188-6_15 Type Book Chapter Author Müller H Publisher Springer Nature Pages 311-330 -
2021
Title The Ten Commandments of Ethical Medical AI DOI 10.1109/mc.2021.3074263 Type Journal Article Author Mller H Journal Computer Pages 119-123 Link Publication -
2021
Title Kandinsky Patterns DOI 10.1016/j.artint.2021.103546 Type Journal Article Author Müller H Journal Artificial Intelligence Pages 103546 Link Publication -
2021
Title Legal aspects of data cleansing in medical AI DOI 10.1016/j.clsr.2021.105587 Type Journal Article Author Stöger K Journal Computer Law & Security Review Pages 105587 Link Publication -
2021
Title Digital Transformation for Sustainable Development Goals (SDGs) - A Security, Safety and Privacy Perspective on AI DOI 10.1007/978-3-030-84060-0_1 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 1-20 -
2022
Title Fairness and Explanation in AI-Informed Decision Making DOI 10.3390/make4020026 Type Journal Article Author Angerschmid A Journal Machine Learning and Knowledge Extraction Pages 556-579 Link Publication -
2022
Title Explainability and causability for artificial intelligence-supported medical image analysis in the context of the European In Vitro Diagnostic Regulation DOI 10.1016/j.nbt.2022.05.002 Type Journal Article Author Müller H Journal New Biotechnology Pages 67-72 Link Publication -
2022
Title xxAI - Beyond Explainable Artificial Intelligence DOI 10.1007/978-3-031-04083-2_1 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 3-10 -
2022
Title Towards Explainability for AI Fairness DOI 10.1007/978-3-031-04083-2_18 Type Book Chapter Author Zhou J Publisher Springer Nature Pages 375-386 -
2022
Title Explainable AI Methods - A Brief Overview DOI 10.1007/978-3-031-04083-2_2 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 13-38 -
2022
Title Digital Transformation in Smart Farm and Forest Operations Needs Human-Centered AI: Challenges and Future Directions DOI 10.3390/s22083043 Type Journal Article Author Holzinger A Journal Sensors Pages 3043 Link Publication -
2022
Title Recommendations on compiling test datasets for evaluating artificial intelligence solutions in pathology DOI 10.1038/s41379-022-01147-y Type Journal Article Author Homeyer A Journal Modern Pathology Pages 1759-1769 Link Publication -
2022
Title Interpretable Machine Learning with Brain Image and Survival Data DOI 10.3390/biomedinformatics2030031 Type Journal Article Author Eder M Journal BioMedInformatics Pages 492-510 Link Publication -
2022
Title Multi-omics disease module detection with an explainable Greedy Decision Forest DOI 10.1038/s41598-022-21417-8 Type Journal Article Author Pfeifer B Journal Scientific Reports Pages 16857 Link Publication -
2022
Title A manifesto on explainability for artificial intelligence in medicine DOI 10.1016/j.artmed.2022.102423 Type Journal Article Author Combi C Journal Artificial Intelligence in Medicine Pages 102423 Link Publication -
2022
Title GNN-SubNet: disease subnetwork detection with explainable graph neural networks DOI 10.1093/bioinformatics/btac478 Type Journal Article Author Pfeifer B Journal Bioinformatics Link Publication -
2022
Title Understanding and Explaining Diagnostic Paths: Toward Augmented Decision Making DOI 10.1109/mcg.2022.3197957 Type Journal Article Author Plass M Journal IEEE Computer Graphics and Applications Pages 47-57 Link Publication -
2022
Title Machine Learning and Knowledge Extraction to Support Work Safety for Smart Forest Operations DOI 10.1007/978-3-031-14463-9_23 Type Book Chapter Author Hoenigsberger F Publisher Springer Nature Pages 362-375 -
2022
Title Effects of Fairness and Explanation on Trust in Ethical AI DOI 10.1007/978-3-031-14463-9_4 Type Book Chapter Author Angerschmid A Publisher Springer Nature Pages 51-67 -
2022
Title The ROC Diagonal is Not Layperson’s Chance: A New Baseline Shows the Useful Area DOI 10.1007/978-3-031-14463-9_7 Type Book Chapter Author Carrington A Publisher Springer Nature Pages 100-113 -
2020
Title Measuring the Quality of Explanations: The System Causability Scale (SCS) DOI 10.1007/s13218-020-00636-z Type Journal Article Author Holzinger A Journal KI - Künstliche Intelligenz Pages 193-198 Link Publication -
2020
Title Expectations of Artificial Intelligence for Pathology DOI 10.1007/978-3-030-50402-1_1 Type Book Chapter Author Regitnig P Publisher Springer Nature Pages 1-15 -
2020
Title Towards a Better Understanding of the Workflows: Modeling Pathology Processes in View of Future AI Integration DOI 10.1007/978-3-030-50402-1_7 Type Book Chapter Author Kargl M Publisher Springer Nature Pages 102-117 -
2020
Title The European Legal Framework for Medical AI DOI 10.1007/978-3-030-57321-8_12 Type Book Chapter Author Schneeberger D Publisher Springer Nature Pages 209-226 -
2020
Title Explainable Artificial Intelligence: Concepts, Applications, Research Challenges and Visions DOI 10.1007/978-3-030-57321-8_1 Type Book Chapter Author Longo L Publisher Springer Nature Pages 1-16 -
2019
Title KANDINSKY Patterns as IQ-Test for Machine Learning DOI 10.1007/978-3-030-29726-8_1 Type Book Chapter Author Holzinger A Publisher Springer Nature Pages 1-14 -
2019
Title Visualization of Histopathological Decision Making Using a Roadbook Metaphor DOI 10.1109/iv.2019.00073 Type Conference Proceeding Abstract Author Pohn B Pages 392-397 -
2022
Title A Literature Review on Ethics for AI in Biomedical Research and Biobanking DOI 10.1055/s-0042-1742516 Type Journal Article Author Kargl M Journal Yearbook of Medical Informatics Pages 152-160 Link Publication -
2022
Title CLARUS: An Interactive Explainable AI Platform for Manual Counterfactuals in Graph Neural Networks DOI 10.1101/2022.11.21.517358 Type Preprint Author Beinecke J Pages 2022.11.21.517358 Link Publication -
2022
Title Human-AI Interfaces are a Central Component of Trustworthy AI DOI 10.1007/978-3-031-12807-3_11 Type Book Chapter Author Plass M Publisher Springer Nature Pages 225-256 -
2022
Title Actionable Explainable AI (AxAI): A Practical Example with Aggregation Functions for Adaptive Classification and Textual Explanations for Interpretable Machine Learning DOI 10.3390/make4040047 Type Journal Article Author Saranti A Journal Machine Learning and Knowledge Extraction Pages 924-953 Link Publication -
2022
Title Generating Explanations for Conceptual Validation of Graph Neural Networks: An Investigation of Symbolic Predicates Learned on Relevance-Ranked Sub-Graphs DOI 10.1007/s13218-022-00781-7 Type Journal Article Author Finzel B Journal KI - Künstliche Intelligenz Pages 271-285 Link Publication